Plasma fatty acids and the risk of metabolic syndrome in ethnic Chinese adults in Taiwan

Chien, Kuo–Liong; Chao, Chia-Lun; Kuo, Chen-Hong; Lin, Hung‐Ju; Liu, Pi-Hua; Chen, Pei-Rony; Hsu, Hsiu-Ching; Lee, Bai-Chin; Lee, Yuan‐Teh; Chen, Ming-Fong

doi:10.1186/1476-511x-10-33

Cited by 22 publications

(13 citation statements)

References 29 publications

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“…Of the 48 articles examined by full-text, an additional 21 articles were excluded for various reasons (e.g., studies without providing n -3 PUFAs composition, studies from prospective cohort, or intervention studies). Finally, 27 studies were eligible for the present study, including 13 studies form Europe [ 8 , 9 , 13 , 14 , 15 , 17 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ], 10 studies from Asia [ 10 , 11 , 12 , 18 , 28 , 29 , 30 , 31 , 32 , 33 ], three studies from North America [ 16 , 34 , 35 ], and one study from South America [ 36 ] ( Table S1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Two prospective cohort studies investigated the association of circulating fatty acids with MetS risk, and the results have suggested null [ 8 ] and inverse associations [ 9 ]. Meanwhile, Several cross-sectional and case-control studies have indicated that plasma/serum n -3 PUFAs was significantly higher in healthy subjects compared with patients with MetS [ 10 , 11 , 12 , 13 ], while some studies have suggested opposite and null associations [ 8 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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n-3 Polyunsaturated Fatty Acids and Metabolic Syndrome Risk: A Meta-Analysis

Guo

Shi

et al. 2017

Nutrients

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The associations between n-3 polyunsaturated fatty acids (PUFAs) and metabolic syndrome (MetS) risk have demonstrated inconsistent results. The present study aimed to investigate whether higher circulating n-3 PUFAs and dietary n-3 PUFAs intake have a protective effect on MetS risk. A systematic literature search in the PubMed, Scopus, and Chinese National Knowledge Infrastructure (CNKI) databases was conducted up to March 2017. Odd ratios (ORs) from case-control and cross-sectional studies were combined using a random-effects model for the highest versus lowest category. The differences of n-3 PUFAs between healthy subjects and patients with MetS were calculated as weighted mean difference (WMD) by using a random-effects model. Seven case-control and 20 cross-sectional studies were included. A higher plasma/serum n-3 PUFAs was associated with a lower MetS risk (Pooled OR = 0.63, 95% CI: 0.49, 0.81). The plasma/serum n-3 PUFAs in controls was significantly higher than cases (WMD: 0.24; 95% CI: 0.04, 0.43), especially docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA). However, no significant association was found between dietary intake of n-3 PUFAs or fish and MetS risk. The present study provides substantial evidence of a higher circulating n-3 PUFAs associated with a lower MetS risk. The circulating n-3 PUFAs can be regarded as biomarkers indicating MetS risk, especially DPA and DHA.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

n-3 Polyunsaturated Fatty Acids and Metabolic Syndrome Risk: A Meta-Analysis

Guo

Shi

et al. 2017

Nutrients

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“…Studies conducted in US and European populations showed that different FAs in the circulation may play different roles in the development of CVD and T2D . In some earlier cross‐sectional or case‐control studies from Chinese populations, the protective roles of polyunsaturated fatty acids (PUFAs) were replicated for the risks of MetS, T2D, and hypertension . Moreover, long‐chain n‐3 FAs and stearic acid were inversely associated with increased incident myocardial infarction in the Singapore Chinese Health Study, whereas arachidonic acid exhibited a positive association .…”

Section: Studies Of Metabolomics In Chinese Populationsmentioning

confidence: 99%

“…[79][80][81] In some earlier cross-sectional or case-control studies from Chinese populations, the protective roles of polyunsaturated fatty acids (PUFAs) were replicated for the risks of MetS, T2D, and hypertension. [34][35][36][37][38][39][40] Moreover, longchain n-3 FAs and stearic acid were inversely associated with increased incident myocardial infarction in the Singapore Chinese Health Study, whereas arachidonic acid exhibited a positive association. 41 In the Nutrition and Health of Aging Population in China (NHAPC) study, a total of 28 erythrocyte FAs was detected by GC and a serial analysis was conducted to evaluate the effects of different FAs on the risks of cardiometabolic diseases.…”

Section: Application Of Metabolomics To Disease-related Risksmentioning

confidence: 99%

Linking of metabolomic biomarkers with cardiometabolic health in Chinese population

Sun

Lin

2018

Journal of Diabetes

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Due to rapid nutrition transitions, the prevalence of cardiometabolic diseases, such as metabolic syndrome, type 2 diabetes, and cardiovascular diseases, has been increasing at an alarming rate in the Chinese population. Moreover, Asians, including Chinese, have been hypothesized to have a higher susceptibility to cardiometabolic diseases than Caucasians. Early prediction and prevention are key to controlling this epidemic trend; to this end, the identification of novel biomarkers is critical to reflect environmental exposure, as well as to reveal endogenous metabolic and pathophysiologic mechanisms. The emerging “omics” technologies, especially metabolomics, offer a unique opportunity to provide novel signatures or fingerprints to understand the effects of genetic and non‐genetic factors on cardiometabolic health. During the past two decades, metabolomic approaches have been increasingly used in various epidemiological studies, primarily in Western populations. Although the field is still in its early stages, some studies have tried to identify novel compounds or confirm their metabolites and associations with cardiometabolic diseases in Chinese populations, including amino acids, fatty acids, acylcarnitines and other metabolites. Despite major efforts to discover novel biomarkers for disease prediction or intervention, the limits in current study design, analytical platforms, and data processing approaches are challenges in metabolomic research worldwide. Therefore, future research with more advanced technologies, rigorous study designs, standardized detection and analytic approaches, and integrated data from multiomics approaches are essential to evaluate the feasibility of using metabolomics in clinical settings. Finally, the functional roles and underlying biological mechanisms of metabolomic biomarkers should be elucidated by future mechanistic research.

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“…In this regard, trans-fatty acids and Omega-3 fatty acids (such as eiscosa pentaenoic acid) have been emphasized as risk factor and protective compound for CVD, respectively (8). Recent studies have shown that epicardial fat is a major risk factor for heart disease (9). The secretion of inflammatory cytokines from this adipose tissue and its proximity with coronary arteries one hand, and the role of epicardial fat in developing the risk factors for CVD including blood pressure on the other, may explain the role of epicardial fat in coronary artery disease (10).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Epicardial Adipose Tissue Fatty Acid Profile in Cardiovascular Disease Patients Diabetic and Non-Diabetic

Nourazarian¹,

Ghaffarian²,

Dolatkhah³

2016

mljgoums

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Background and Objective: The relationship between diabetes mellitus and increased risk of cardiovascular diseases has been demonstrated. The aim of this study was to determine the fatty acid profile of epicardial adipose tissue in diabetic and non-diabetic patients with cardiovascular disease. Methods: In this study, 28 diabetic and 40 nondiabetic patients were evaluated. The epicardial adipose tissue and blood samples of patients were collected during surgery. Nonesterified fatty acids and phospholipids were measured by the thin layer chromatography and gas chromatography. Results: Saturated free fatty acids (12: 0) level was higher in diabetic patients compared to nondiabetic patients (P=0.038), while saturated free fatty acids (16: 0) was significantly lower in diabetics (P=0.011). Unsaturated fatty acid (20: 3n-9) was higher in nondiabetics compared to diabetics (P=0.015). There was a significant decrease in level of monounsaturated fatty acids in diabetic patients. The epicardial adipose tissue of diabetics showed a significant increase in free fatty acid (18: 0) and conjugated linoleic acid levels, while there was a significant decrease in the level of free fatty acid (18: 1n-11). Level of epicardial omega-3 free fatty acid (20: 5 n-3) and 22: 6 n-3 was significantly reduced in these patients. Conclusion: Differences in the serum free fatty acid profile of the two groups may be due to differences in their diet, while changes in the fatty acid composition of epicardial adipose tissue in these two groups could be due to impaired metabolism of fatty acids such as uptake, movement and androgen synthesis as a result of diabetes. These changes increase the risk of developing atherosclerosis in diabetic patients.

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Plasma fatty acids and the risk of metabolic syndrome in ethnic Chinese adults in Taiwan

Cited by 22 publications

References 29 publications

n-3 Polyunsaturated Fatty Acids and Metabolic Syndrome Risk: A Meta-Analysis

n-3 Polyunsaturated Fatty Acids and Metabolic Syndrome Risk: A Meta-Analysis

Linking of metabolomic biomarkers with cardiometabolic health in Chinese population

Comparison of Epicardial Adipose Tissue Fatty Acid Profile in Cardiovascular Disease Patients Diabetic and Non-Diabetic

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