Plasma Exosomal CircNEK9 Accelerates the Progression of Gastric Cancer via miR-409-3p/MAP7 Axis

Yu, Li; Xie, Jie; Liu, Xiaoming; Yan, Yu; Wang, Siping

doi:10.1007/s10620-020-06816-z

Cited by 27 publications

(32 citation statements)

References 37 publications

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“…Yu et al reported that exosome-triggered transfer of circNEK9 accelerated the proliferation, migration and invasion of GC cells by targeting miR-409-3p. 11 CircNHSL1 was highly expressed in GC tissues, GC cells and GC cells derived exosomes. Study disclosed that knockdown of circNHSL1 represses the migration and invasion in GC cells and inhibits tumor growth, implying a potential diagnostic marker for the occurrence and development of GC.…”

Section: Exosomal Circrnas and Occurrence And Development Of Gcmentioning

confidence: 97%

“…10 Although studies have demonstrated that circRNAs are enriched and stable in exosomes, the biological function of exosomal circRNAs in the occurrence, development, diagnosis and prognosis of GC is still unclear. [11][12][13] In this review, we highlight and discuss about the relationship between exosomes, exosomal circRNAs and GC, with a special focus on the roles, mechanisms of actions, and potential clinical application values as biomarkers and therapeutic targets in GC. Our review provides insight into the role exosomes and exosomal circRNAs in the occurrence, development and prognosis of GC, which may provide a new entry point for discovering new diagnostic and prognosis markers and therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

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Exosomes and Exosomal circRNAs: The Rising Stars in the Progression, Diagnosis and Prognosis of Gastric Cancer

Lü¹,

Fang²,

Zhang³

et al. 2021

CMAR

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Gastric cancer (GC) is a common malignant tumor affecting human health, with occult onset and poor prognosis. Exosomes are extracellular vesicles secreted by almost all cells, which can reflect the state of source cells or tissues. It is reported that exosomes are involved in almost all processes of GC. Exosomes provided a window to understand changes in cell or tissue states by carrying active components such as circular RNAs (circRNAs). CircRNAs are a naturally occurring class of endogenous noncoding RNAs and abnormal expression during the occurrence and development of GC. Exosomal circRNAs are those circRNAs stably existing in exosomes and having high clinical values as novel potential diagnosis and prognosis biomarkers of GC, which have the characteristics of abnormal expression, tissue specificity and development stage specificity. Herein, we briefly summarize the functions and roles and the current research progress of exosomes and exosomal circRNAs in GC with a focus on the potential application for GC progression, diagnosis and prognosis. We also prospected the clinical application of exosomes and exosomal circRNAs in the future.

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Section: Exosomal Circrnas and Occurrence And Development Of Gcmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Exosomes and Exosomal circRNAs: The Rising Stars in the Progression, Diagnosis and Prognosis of Gastric Cancer

Lü¹,

Fang²,

Zhang³

et al. 2021

CMAR

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“…In addition to miRNAs and lncRNAs, exosomal circRNAs that play essential roles in the proliferation, invasion, and metastasis of GC have been reported, such as circSHKBP1 (74), circNRIP1 (59), circNEK9 (75), and circ-RanGAP1 (76). Xie et al observed the increased expression of circSHKBP1 in both GC tissues and serum, but the decreased level of exosome circSHKBP1 following gastrectomy.…”

Section: Exosomal Ncrnas and Gc Proliferation Invasion And Metastasismentioning

confidence: 99%

Section: Biological Functions Of Exosomal Ncrnas In Gcmentioning

confidence: 99%

“…In addition, circNEK9 and circ-RanGAP1 were significantly upregulated in both tissues and plasma exosomes of GC patients. The plasma exosomal circNEK9 and circ-RanGAP1 promoted the migration and invasion of recipient GC cells to subsequently promote GC progression through the miR-409-3p/MAP7 and miR-877-3p/VEGFA axes, respectively ( 75 , 76 ). In summary, these studies demonstrate that the selective secretion and transmission of ncRNAs between cells through exosomes play significant roles in regulating the proliferation, invasion, and metastasis of GC.…”

Section: Biological Functions Of Exosomal Ncrnas In Gcmentioning

confidence: 99%

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Role of Exosomal Non-coding RNAs in Gastric Cancer: Biological Functions and Potential Clinical Applications

Liu

et al. 2021

Front. Oncol.

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Gastric cancer (GC) is one of the most common fatal cancers worldwide. The communication between GC and other cells in the GC microenvironment directly affects GC progression. Recently, exosomes have been revealed as new players in intercellular communication. They play an important role in human health and diseases, including cancer, owing to their ability to carry various bioactive molecules, including non-coding RNAs (ncRNAs). NcRNAs, including micro RNAs, long non-coding RNAs, and circular RNAs, play a significant role in various pathophysiological processes, especially cancer. Increasing evidence has shown that exosomal ncRNAs are involved in the regulation of tumor proliferation, invasion, metastasis, angiogenesis, immune regulation, and treatment resistance in GC. In addition, exosomal ncRNAs have promising potential as diagnostic and prognostic markers for GC. Considering the biocompatibility of exosomes, they can also be used as biological carriers for targeted therapy. This review summarizes the current research progress on exosomal ncRNAs in gastric cancer, focusing on their biological role in GC and their potential as new biomarkers for GC and therapeutics. Our review provides insight into the mechanisms involved in GC progression, which may provide a new point cut for the discovery of new diagnostic markers and therapeutic strategies.

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Circular RNAs in human diseases

Wang,

Zhang,

Yang

et al. 2024

MedComm

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Circular RNAs (circRNAs) are a unique class of RNA molecules formed through back‐splicing rather than linear splicing. As an emerging field in molecular biology, circRNAs have garnered significant attention due to their distinct structure and potential functional implications. A comprehensive understanding of circRNAs’ functions and potential clinical applications remains elusive despite accumulating evidence of their involvement in disease pathogenesis. Recent research highlights their significant roles in various human diseases, but comprehensive reviews on their functions and applications remain scarce. This review provides an in‐depth examination of circRNAs, focusing first on their involvement in non‐neoplastic diseases such as respiratory, endocrine, metabolic, musculoskeletal, cardiovascular, and renal disorders. We then explore their roles in tumors, with particular emphasis on exosomal circular RNAs, which are crucial for cancer initiation, progression, and resistance to treatment. By detailing their biogenesis, functions, and impact on disease mechanisms, this review underscores the potential of circRNAs as diagnostic biomarkers and therapeutic targets. The review not only enhances our understanding of circRNAs’ roles in specific diseases and tumor types but also highlights their potential as novel diagnostic and therapeutic tools, thereby paving the way for future clinical investigations and potential therapeutic interventions.

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Plasma Exosomal CircNEK9 Accelerates the Progression of Gastric Cancer via miR-409-3p/MAP7 Axis

Cited by 27 publications

References 37 publications

Exosomes and Exosomal circRNAs: The Rising Stars in the Progression, Diagnosis and Prognosis of Gastric Cancer

Exosomes and Exosomal circRNAs: The Rising Stars in the Progression, Diagnosis and Prognosis of Gastric Cancer

Role of Exosomal Non-coding RNAs in Gastric Cancer: Biological Functions and Potential Clinical Applications

Circular RNAs in human diseases

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