Plasma exchange and leukapheresis in psoriasis ? no effect?

Liedén, Gudrun; Skogh, M

doi:10.1007/bf00455159

Cited by 16 publications

(5 citation statements)

References 11 publications

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“…The plaques and papules are a result of hyperproliferation and abnormal differentiation of the epidermis. One small controlled trial and one small series showed that TPE provides no benefit in the treatment of psoriasis [25,26].…”

Section: Psoriasismentioning

confidence: 99%

Category IV indications for therapeutic apheresis—ASFA fourth special issue

Shaz

Linenberger

Bandarenko

et al. 2007

J of Clinical Apheresis

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The American Society for Apheresis (ASFA) Committee on Clinical Applications systematically and critically reviews published information on the use of therapeutic apheresis in clinical practice. On the basis of this review, selected diseases are assigned one of five categories (category I, II, III, IV, and P). The diseases, which were classified as category IV indications, and the rationale for such assignment are reviewed in this article. The diseases assigned to category I, II, III, and newly created category P are discussed in a separate article in this issue.

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Section: Psoriasismentioning

confidence: 99%

Category IV indications for therapeutic apheresis—ASFA fourth special issue

Shaz

Linenberger

Bandarenko

et al. 2007

J of Clinical Apheresis

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“…Skin lesions responded favorably in 6 out of 9 patients treated with plasma exchange, but the effect was transient [14]. A similar beneficial but transient effect was found in most of the 9 patients subjected to plasma exchange and/or leukapheresis, including 2 patients with arthritis [15]. Plasma exchange was also reported to have a beneficial effect on psoriasis arthropathy in the 10 patients treated by Grivert et al [16], although the duration of remission was not given.…”

Section: Introductionmentioning

confidence: 70%

Effects of Cascade Apheresis in Patients with Psoriasis and Psoriatic Arthropathy

Jørstad

Bergh²,

Iversen³

et al. 1998

Blood Purif

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Eight patients with psoriasis, all with skin scales and 7 with disabling psoriatic arthritis, were subjected to cascade apheresis starting with three treatments per week for 2 weeks, followed by one treatment a week, comprising ten treatments in all. Six out of 7 patients (86%) with arthropathy and 3 out of 8 patients (38%) with scales experienced a beneficial effect. There was a large drop in the levels of circulating immune complexes (CIC) due to the treatment, and the removal of CIC was followed by reduced inflammatory activity in skin lesions and joints as evaluated by pain, morning stiffness, grip strength, plaque score, and PASI index. However, there was no correlation between the level of CIC, disease activity, or treatment response. From the present results it is concluded that CIC may play a more significant role regarding psoriatic arthropathy than in skin manifestations, and apheresis may be beneficial in patients not responding to conventional therapy.

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“…This cellular infiltrate changed with topical or systemic treatment (Baker et al, 1985;Bos & Krieg, 1985). In another study, failure of plasma exchange and leukapheresis ruled out the major participation of humoral immune system in the pathogenesis of psoriasis (Lieden & Skogh, 1986). Thus, the cellular arm of the immune system was implicated in psoriasis for the first time during the 1980s (Valdimarsson et al, 1986).…”

Section: Pre-biologic Immunological History Of Psoriasismentioning

confidence: 99%