Plasma-Etching for Controlled Modification of Structural and Mechanical Properties of Electrospun PET Scaffolds

Savoji, Houman; Lerouge, Sophie; Ajji, Abdellah; Wertheimer, M. R.

doi:10.1002/ppap.201400147

Cited by 29 publications

(34 citation statements)

References 59 publications

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“…Our team has investigated how electrospun polyethylene terephthalate (ePET) mat properties such as fiber diameter, orientation and surface characteristics affect EC adhesion, spreading, infiltration and migration [11][12][13][14]. PET was selected for its good mechanical properties, stability, biocompatibility, and low cost.…”

Section: Introductionmentioning

confidence: 99%

Combining Electrospun Fiber Mats and Bioactive Coatings for Vascular Graft Prostheses

et al. 2016

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The patency of small-diameter (<6 mm) synthetic vascular grafts (VGs) is still limited by the absence of a confluent, blood flow-resistant monolayer of endothelial cells (ECs) on the lumen and of vascular smooth muscle cell (VSMC) growth into the media layer. In this research, electrospinning has been combined with bioactive coatings based on chondroitin sulfate (CS) to create scaffolds that possess optimal morphological and bioactive properties for subsequent cell seeding. We fabricated random and aligned electrospun poly(ethylene terephthalate), ePET, mats with small pores (3.2 ± 0.5 or 3.9 ± 0.3 μm) and then investigated the effects of topography and bioactive coatings on EC adhesion, growth, and resistance to shear stress. Bioactive coatings were found to dominate the cell behavior, which enabled creation of a near-confluent EC monolayer that resisted physiological shear-flow conditions. CS is particularly interesting since it prevents platelet adhesion, a key issue to avoid blood clot formation in case of an incomplete EC monolayer or partial cell detachment. Regarding the media layer, circumferentially oriented nanofibers with larger pores (6.3 ± 0.5 μm) allowed growth, survival, and inward penetration of VSMCs, especially when the CS was further coated with tethered, oriented epithelial growth factor (EGF). In summary, the techniques developed here can lead to adequate scaffolds for the luminal and media layers of small-diameter synthetic VGs.

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Section: Introductionmentioning

confidence: 99%

Combining Electrospun Fiber Mats and Bioactive Coatings for Vascular Graft Prostheses

et al. 2016

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“…In the case of many polymers 4,5,6,7 , the mats produced by electrospinning are hydrophobic and need to undergo a post-treatment in order to present hydrophilicity. This can be achieved by hydrolysis 4,5 , plasma 8 , immersion precipitation 9 , etc., but this adds time and cost. Another approach is to use polymer blending to incorporate hydrophilic 10 or amphiphilic 11,12 polymers in the hydrophobic matrix to alter the surface properties of the fibers.…”

Section: Introductionmentioning

confidence: 99%

Wetting of Hydrophilic Electrospun Mats Produced by Blending SEBS with PEO–PPO–PEO Copolymers of Different Molecular Weight

Kurusu

Demarquette

2016

Langmuir

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The interaction of electrospun mats with water is critical for many possible applications, and the water contact angle on the surface is the parameter usually measured to characterize wetting. Although useful for hydrophobic surfaces, this approach is limited for hydrophilic mats, where wicking has also to be considered. In this case, it is still unclear how the fiber surface chemical composition and morphology will affect the wetting behavior of electrospun mats. In this work, wetting was studied with different hydrophilic membranes produced by blending thermoplastic elastomer SEBS with amphiphilic PEO-PPO-PEO molecules. Three different types of PEO-PPO-PEO, with different molar masses, PEO content and physical form were used. The effect of these differences on the wetting behavior of the electrospun mats was evaluated by contact angle goniometry, wicking measurements and 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 2 different imaging techniques. X-ray photoelectron spectroscopy was used to characterize the surface chemical composition. The smaller molecules quickly saturated the surface at low concentrations, making the mats hydrophilic. The sheath of PEO-PPO-PEO also resulted in fast absorption of water, when comparing the saturated and non-saturated surfaces. Longer PEO chain-ends seemed to hinder complete segregation and also led to a higher activation time when in contact with water. Liquid PEO-PPO-PEO was easily leached by water.

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“…However, because the melting point of PAN was higher than the ACFs bonding temperature, PAN skin should be removed for stable electrical interconnection. Therefore, the thin PAN insulating layer was removed by an oxygen plasma-etching method [7][8]. After the optimized plasma treatment, thin PAN insulating layer was completely removed as shown in Fig 4.…”

Section: Resultsmentioning

confidence: 99%

82‐4: Effects of the Anchoring Polymer Layer (APL) Materials on Conductive Particle Movements for Ultra‐Fine Pitch Chip‐on‐Glass (COG) Interconnection

Yoon

Paik

2018

Symp Digest of Tech Papers

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In this study, APL has been introduced into the ACFs system. Then, the effects of APL ACFs properties on the conductive particle movement and interconnection stability of ultra-fine pitch COG applications were investigated. The APL structure can not only significantly suppress the conductive particles movement for ultra-fine pitch COG applications but also prevent electrical short circuit formation between electrodes. After ACFs bonding process, the percentage of captured conductive particles of the conventional ACFs was 33%, however, that of PAN APL ACFs showed 95%. In addition, the APL ACFs showed excellent electrical properties such as stable contact resistance without any open or short circuits.

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Plasma-Etching for Controlled Modification of Structural and Mechanical Properties of Electrospun PET Scaffolds

Cited by 29 publications

References 59 publications

Combining Electrospun Fiber Mats and Bioactive Coatings for Vascular Graft Prostheses

Combining Electrospun Fiber Mats and Bioactive Coatings for Vascular Graft Prostheses

Wetting of Hydrophilic Electrospun Mats Produced by Blending SEBS with PEO–PPO–PEO Copolymers of Different Molecular Weight

82‐4: Effects of the Anchoring Polymer Layer (APL) Materials on Conductive Particle Movements for Ultra‐Fine Pitch Chip‐on‐Glass (COG) Interconnection

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