Plasma ET-1 Concentrations Are Elevated in Pregnant Women with Hypertension -Meta-Analysis of Clinical Studies

Lu, Yongping; Hasan, Ahmed A.; Zeng, Shufei; Hocher, Berthold

doi:10.1159/000482004

Cited by 24 publications

(9 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Endothelial Damage In Preeclampsiamentioning

confidence: 99%

“…Overall, the pathogenic vascular state of preeclampsia can be attributed to the decreased synthesis of relaxing substances and elevated vasoconstrictive signaling [ 218 , 219 ]. This signaling may be a consequence of increased abundance or sensitivity to vasoconstrictive hormones as well as disinhibition of these pathways [ 213 , 215 , 218 , 219 ]. Vascular resistance has profound effects, both systemically and on specific vascular beds, and has been demonstrated experimentally in vivo, ex vivo, and in vitro [ 152 , 154 , 197 , 205 , 207 ].…”

Section: Endothelial Damage In Preeclampsiamentioning

confidence: 99%

See 1 more Smart Citation

Vascular Dysfunction in Preeclampsia

Opichka

Rappelt

Gutterman

et al. 2021

Cells

View full text Add to dashboard Cite

Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact underlying cause is not precisely defined and likely heterogenous, a plethora of research indicates that in some women with preeclampsia, both maternal and placental vascular dysfunction plays a role in the pathogenesis and can persist into the postpartum period. Potential abnormalities include impaired placentation, incomplete spiral artery remodeling, and endothelial damage, which are further propagated by immune factors, mitochondrial stress, and an imbalance of pro- and antiangiogenic substances. While the field has progressed, current gaps in knowledge include detailed initial molecular mechanisms and effective treatment options. Newfound evidence indicates that vasopressin is an early mediator and biomarker of the disorder, and promising future therapeutic avenues include mitigating mitochondrial dysfunction, excess oxidative stress, and the resulting inflammatory state. In this review, we provide a detailed overview of vascular defects present during preeclampsia and connect well-established notions to newer discoveries at the molecular, cellular, and whole-organism levels.

show abstract

Section: Endothelial Damage In Preeclampsiamentioning

confidence: 99%

Section: Endothelial Damage In Preeclampsiamentioning

confidence: 99%

Vascular Dysfunction in Preeclampsia

Opichka

Rappelt

Gutterman

et al. 2021

Cells

View full text Add to dashboard Cite

show abstract

“…ET-1 is a highly potent vasoconstrictor ( 45 ). It is upregulated by mechanical stretch ( 46 ) and hypoxia ( 47 ), and plasma ET-1 is elevated in preeclampsia and gestational hypertension ( 48 , 49 ). It exerts its effects by binding G-protein coupled receptors on vascular smooth muscle cells and endothelial cells ( 50 ), a byproduct of which may be intracellular lipid accumulation ( 51 , 52 ).…”

Section: Acute Atherosis Etiologymentioning

confidence: 99%

Acute Atherosis Lesions at the Fetal-Maternal Border: Current Knowledge and Implications for Maternal Cardiovascular Health

et al. 2021

View full text Add to dashboard Cite

Decidua basalis, the endometrium of pregnancy, is an important interface between maternal and fetal tissues, made up of both maternal and fetal cells. Acute atherosis is a uteroplacental spiral artery lesion. These patchy arterial wall lesions containing foam cells are predominantly found in the decidua basalis, at the tips of the maternal arteries, where they feed into the placental intervillous space. Acute atherosis is prevalent in preeclampsia and other obstetric syndromes such as fetal growth restriction. Causal factors and effects of acute atherosis remain uncertain. This is in part because decidua basalis is challenging to sample systematically and in large amounts following delivery. We summarize our decidua basalis vacuum suction method, which facilitates tissue-based studies of acute atherosis. We also describe our evidence-based research definition of acute atherosis. Here, we comprehensively review the existing literature on acute atherosis, its underlying mechanisms and possible short- and long-term effects. We propose that multiple pathways leading to decidual vascular inflammation may promote acute atherosis formation, with or without poor spiral artery remodeling and/or preeclampsia. These include maternal alloreactivity, ischemia-reperfusion injury, preexisting systemic inflammation, and microbial infection. The concept of acute atherosis as an inflammatory lesion is not novel. The lesions themselves have an inflammatory phenotype and resemble other arterial lesions of more extensively studied etiology. We discuss findings of concurrently dysregulated proteins involved in immune regulation and cardiovascular function in women with acute atherosis. We also propose a novel hypothesis linking cellular fetal microchimerism, which is prevalent in women with preeclampsia, with acute atherosis in pregnancy and future cardiovascular and neurovascular disease. Finally, women with a history of preeclampsia have an increased risk of premature cardiovascular disease. We review whether presence of acute atherosis may identify women at especially high risk for premature cardiovascular disease.

show abstract

“…Preeclampsia is a multisystem disorder involving abnormalities in multiple signaling pathways including the ET-1 system. A recent meta-analysis study of 16 published cohort studies, including 1739 hypertensive cases and 409 controls, revealed that ET-1 plasma concentrations are elevated in hypertensive pregnant women as compared to normotensive controls [34]. Further, umbilical vein concentrations of ET-1 in preeclampsia are higher than in normal pregnancy [35].…”

Section: Endothelin Receptor a As A Therapeutic Target For Preeclampsiamentioning

confidence: 99%

Sex-Specific Contributions of Endothelin to Hypertension

Gohar

Pollock

2018

Curr Hypertens Rep

View full text Add to dashboard Cite

The current review will highlight evidence for the potential role for endothelin system in the pathophysiology of hypertension within three female populations: (i) postmenopausal women, (ii) women suffering from preeclampsia, or (iii) pulmonary arterial hypertension. Clinical trials that specifically address cardiovascular and renal diseases in females under different hormonal status are limited. Studies of the modulatory role of gonadal hormones and sex-specific mechanisms on critically important systems involved, such as endothelin, are needed to establish new clinical practice guidelines based on systematic evidence.

show abstract

Plasma ET-1 Concentrations Are Elevated in Pregnant Women with Hypertension -Meta-Analysis of Clinical Studies

Cited by 24 publications

References 47 publications

Vascular Dysfunction in Preeclampsia

Vascular Dysfunction in Preeclampsia

Acute Atherosis Lesions at the Fetal-Maternal Border: Current Knowledge and Implications for Maternal Cardiovascular Health

Sex-Specific Contributions of Endothelin to Hypertension

Contact Info

Product

Resources

About