Plasma esterase activity in patients with aspirin-sensitive asthma or urticaria

Abstract

Plasma aspirin esterase activity and cholinesterase activity were reduced in patients with aspirin sensitive asthma and aspirin sensitive urticaria compared to asthmatic and dermatological controls. Phenylacetate (non specific) esterase activities, were however unaltered in these patients. The reason for the lower activity is uncertain but it does not appear to be due to genetically determined lower cholinesterase or due to the avoidance of aspirin by sensitive patients. A low aspirin esterase activity may be a contributory factor in precipitating these aspirin sensitive reactions.

Effects of Different Carboxylic Ester Spacers on Chemical Stability, Release Characteristics, and Anticancer Activity of Mono-PEGylated Curcumin Conjugates

“…The experiment followed the method previously reported by Williams et al 47 with a modification. Briefly, 1.0 mL freshly prepared aspirin solution (10 mM) was incubated for 40 min at 37 • C with 0.6 mL plasma, 3.4 mL buffer solution pH 7.4 (containing 600 mM Tris-HCl and 400 mM CaCl 2 ), and 5.0 mL water.…”

Aspirin esterase(s) – Much known, more to learn

“…While the finding of 28.7% lower activity of plasma aspirin esterase activity in aspirin sensitive asthmatics and of 29.5% in those with aspirin sensitive urticaria, compared with controls, awaits explanation [8], low activities in chronic hepatitis, cirrhosis and heart failure are probably a reflection of reduced synthesis resulting from hypoxia [9][10][11]. Reduced levels have also been reported in Reye's syndrome [12].…”

Intracellular Erythrocyte Platelet-activating Factor Acetylhydrolase I Inactivates Aspirin in Blood

“…Attention has focused on a phenomenon of aspirin ineffectiveness where not all individuals or populations appear to receive the full prophylactic or therapeutic benefits of aspirin (12)(13)(14)(15)(16). The physiologic basis for this aspirin resistance is undefined, and even whether the phenomenon is real or documentable is debated (17).…”