Plasma Epstein Barr viral load in adult-onset Hodgkin lymphoma in South India

Sinha, Mahua; Rao, Clementina Rama; Shafiulla, M.; Shankaranand, B.; Viveka, Belathur; Lakshmaiah, K C; Jacob, Linu Abraham; Babu, Govind; Jayshree, R. S.

doi:10.1016/j.hemonc.2015.11.004

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…Our literature search yielded 135 studies [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 ,…”

Section: Resultsunclassified

“…DNA from EBV-associated lymphoma is derived as naked DNA fragments from apoptotic or necrotic tumor cells [ 35 , 38 ], whereas it is undetectable in non-EBV-associated tumors or healthy people [ 24 ]. Although plasma EBV DNA has recently become more important in the diagnosis and management of EBV-associated cancers [ 41 ], particularly Hodgkin’s lymphoma (HL) [ 41 , 42 ] and nasopharyngeal carcinoma [ 43 , 44 ], there are limited data on the diagnostic and prognostic significance of plasma EBV DNA for BL. In order to identify EBV in various types of samples, methods such as the heterophile antibody test, immunofluorescence assays, enzyme immunoassays, Western blot, and polymerase chain reaction (PCR) are used.…”

Section: Introductionmentioning

confidence: 99%

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Worldwide Prevalence of Epstein–Barr Virus in Patients with Burkitt Lymphoma: A Systematic Review and Meta-Analysis

et al. 2023

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Burkitt lymphoma (BL) is a form of B-cell malignancy that progresses aggressively and is most often seen in children. While Epstein–Barr virus (EBV) is a double-stranded DNA virus that has been linked to a variety of cancers, it can transform B lymphocytes into immortalized cells, as shown in BL. Therefore, the estimated prevalence of EBV in a population may assist in the prediction of whether this population has a high risk of increased BL cases. This systematic review and meta-analysis aimed to estimate the prevalence of Epstein–Barr virus in patients with Burkitt lymphoma. Using the appropriate keywords, four electronic databases were searched. The quality of the included studies was assessed using the Joanna Briggs Institute’s critical appraisal tool. The results were reported as percentages with a 95% confidence interval using a random-effects model (CI). PROSPERO was used to register the protocol (CRD42022372293), and 135 studies were included. The prevalence of Epstein–Barr virus in patients with Burkitt lymphoma was 57.5% (95% CI: 51.5 to 63.4, n = 4837). The sensitivity analyses demonstrated consistent results, and 65.2% of studies were of high quality. Egger’s test revealed that there was a significant publication bias. EBV was found in a significantly high proportion of BL patients (more than 50% of BL patients). This study recommends EBV testing as an alternative for predictions and the assessment of the clinical disease status of BL.

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Section: Resultsunclassified

Section: Introductionmentioning

confidence: 99%

Worldwide Prevalence of Epstein–Barr Virus in Patients with Burkitt Lymphoma: A Systematic Review and Meta-Analysis

et al. 2023

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“…Therefore, it could serve as a promising and convenient detection tool for the EBV-associated HL cases. 27 , 28 …”

Section: Discussionmentioning

confidence: 99%

Evaluation of plasma Epstein–Barr virus DNA as a biomarker for Epstein–Barr virus–associated Hodgkin lymphoma

et al. 2021

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Objectives: Epstein–Barr virus is a tumorigenic virus and has been extensively studied as a causative agent for Hodgkin lymphoma. Although immunostaining of the tumor biopsy is the standard method for diagnosis of Epstein–Barr virus-driven Hodgkin lymphoma, the invasiveness of the procedure renders it difficult and less desirable for the patients. Therefore, we designed this study to evaluate the efficiency of plasma Epstein–Barr virus DNA detection as an alternative diagnostic and prognostic method for Epstein–Barr virus–associated Hodgkin lymphoma. Methods: This analytical cross-sectional study was conducted during March 2017 to December 2018 including 43 Hodgkin lymphoma patients diagnosed histopathologically followed by the latent membrane protein-1 immunohistochemistry to determine their Epstein–Barr virus association. Plasma Epstein–Barr virus DNA in these samples was measured using quantitative polymerase chain reaction (qPCR). Results: Of total, 29 (67.44%) patients tested positive for plasma Epstein–Barr virus DNA. On comparing results of latent membrane protein-1 immunohistochemistry (IHC) with plasma Epstein–Barr virus DNA, plasma Epstein–Barr virus DNA was found in 25 of 30 patients with latent membrane protein-1 expression and 4 of 13 patients without latent membrane protein-1 expression. The sensitivity and the specificity of plasma Epstein–Barr virus DNA detection with respect to latent membrane protein-1 IHC were found to be 83.33% and 69.23%, respectively ( p = 0.0014). Conclusion: Determination of plasma Epstein–Barr virus DNA was found to be highly sensitive and specific in characterizing Epstein–Barr virus–associated Hodgkin lymphoma, suggesting that this diagnostic method holds promise as an alternative and more convenient method of diagnosis compared with tissue biopsy.

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“…In Brazil, 43% (13/30) of the patients with HL had EBV-DNA and 8% (1/13) of healthy individuals were positive for EBV-DNA (Musacchio et al, 2006). In India,EBV-DNA was detected in 49% (16/33) of HL patients and not in controls (Sinha et al, 2016).In Iran, 35/56 (62.5%) of GC patients and 3/56 (5.4%) of controls, were EBV-DNA positive (Amoueian et al, 2018). In Ghana, the number of EBV-DNA positives were 67% (37/55) and 92% (48/53) for NPC patients and controls, respectively (Ayee et al, 2020).…”

Section: Molecular Detection Of Ebv Among Study Groupsmentioning

confidence: 99%

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Study areas include cell biology, genomics, microbiology, immunology, molecular biology, biochemistry, embryology, immunogenetics, cell and tissue culture, molecular ecology, genetic engineering and biological engineering, bioremediation and biodegradation, bioinformatics, biotechnology regulations, gene therapy, organismal biology, microbial and environmental biotechnology, marine sciences. The JJBS welcomes the submission of manuscript that meets the general criteria of significance and academic excellence. All articles published in JJBS are peerreviewed. Papers will be published approximately one to two months after acceptance.

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Plasma Epstein Barr viral load in adult-onset Hodgkin lymphoma in South India

Abstract: Plasma EBV DNA load estimation may be useful in detecting EBV-association and possibly monitoring the response to therapy in EBV-related HL especially in our country where EBV association of HL is higher than in developed nations.

Cited by 6 publications

References 25 publications

Worldwide Prevalence of Epstein–Barr Virus in Patients with Burkitt Lymphoma: A Systematic Review and Meta-Analysis

Worldwide Prevalence of Epstein–Barr Virus in Patients with Burkitt Lymphoma: A Systematic Review and Meta-Analysis

Evaluation of plasma Epstein–Barr virus DNA as a biomarker for Epstein–Barr virus–associated Hodgkin lymphoma

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