Plasma endothelin‐1 in acute heart failure: pathophysiological and preanalytical considerations

A Network Pharmacology Approach to Explore the Mechanisms of Qishen Granules in Heart Failure

“…In the core QSG-HF PPI network, 57 QSG core targets were obtained and the top 10 targets were screened according to degree. Among the 10 genes, EDN1, a peptide that involves in maintaining vascular tone and cardiovascular system homeostasis [36,37], had the largest value of degree, implicating its critical role in the QSG-HF PPI network. It was targeted by 7 molecules which originated from 4 herbs including Dihydrokaranone (CID177072) from Danshen, 3-methyl-6,7,8-trihydropyrrolo[1,2-A]pyrimidin-2-one (CID 5319799) from Gancao, FA (CID 6037) and canavanine (CID 46224610) from Huangqi, Beta-Pinene (CID14896), 1-hexene (CID 11597) and stigmasterol (CID 5280794) from Jinyinhua.…”

Endothelin‐1 is independently associated with 180‐day mortality after adjusting for body mass index

“…1 raise the possibility that overweight and obesity may be confounding the independent association between baseline endothelin-1 (ET-1) and 180-day mortality in patients with acute decompensated heart failure which we previously reported in a cohort from the ASCEND-HF trial. 2 In an effort to assess this possibility, we included body mass index (BMI) as a covariate in an additional multivariable analysis (which also included age, systolic blood pressure, and blood urea nitrogen).…”

“…Monneret et al 1 also raise for discussion the relationship between ET-1, obstructive sleep apnoea (OSA), and mortality. A recent large study involving 1117 hospitalized patients with acute decompensated heart failure who underwent sleep testing showed that OSA was independently associated with 3-year post-discharge mortality.…”