Plasma endothelin-1 and clinical manifestations of neonatal sepsis

Abstract

Plasma ET-1 levels in neonatal sepsis are related to the severity of clinical manifestations, especially oliguria, acidosis and systemic hypotension.

Biomarkers of endothelial dysfunction: can they help us deciphering systemic inflammation and sepsis?

“…Hence, ET-1 might also be a good marker to detect sepsis especially in newborns with the same reliability than CRP or PCT in adults. Figueras-Aloy et al (2004) demonstrated that plasma ET-1 levels in neonatal sepsis are related to the severity of clinical manifestations, especially oliguria, acidosis, and systemic hypotension. Taken together, proET-1 levels in CAP patients at admission may be independent predictors of short-term mortality and the need for ICU admission, correlating strongly with the CURB-65 score.…”

Endothelin receptor antagonist attenuates inflammatory response and prolongs the survival time in a neonatal sepsis model

“…There is substantial evidence that ET-1 is elevated in neonates and infants with pulmonary hypertension and that it is a marker of sepsis severity [2,3]. In fact, studies in animals and humans demonstrate that ET-1 causes pulmonary hypertension, and high plasma levels of ET-1 have been demonstrated in various septic conditions and are associated with morbidity and mortality in septic patients [4][5][6].…”

Endothelin receptor antagonist attenuates oxidative stress in a neonatal sepsis piglet model

“…The production of excessive amounts of cytokines in response to an endotoxin is known to stimulate the production of ET-1 from the endothelium (1). There is substantial evidence that ET-1 is elevated in neonates and infants with pulmonary hypertension and that it can serve as a marker of sepsis severity (2,3).…”