Plasma endothelin-1 and cardiovascular risk among young and healthy adults

Plasma levels of endothelin-1 and renal function among young and healthy adults

“…Our ET-1 assay's limits of blank and quantification were 0.07 pg/mL and 0.33 pg/mL, respectively. Inter-assay coefficients of variation were 7% at an ET-1 concentration of 1.2 pg/mL and 6% at an ET-1 concentration of 1.8 pg/mL [24].…”

“…After centrifugation, the samples were immediately stored at -80 °C. ET-1 was obtained from frozen EDTA plasma samples by using a high-sensitivity, single-molecule counting assay (Erenna ® Immunoassay System, Singulex, Inc., Alameda, CA, USA) [24]. Our ET-1 assay's limits of blank and quantification were 0.07 pg/mL and 0.33 pg/mL, respectively.…”

“…However, the eGFR assessment with the CKD-EPI formula reflects a broadly validated tool for determination renal function, even among young individuals [38][39][40]. In addition, it has been shown that levels of ET-1 are closely and directly linked to endothelial dysfunction and presence of atherosclerosis [24,41].…”

“…However, the advent of simple high-sensitivity assays lately enabled rapid determination plasma-derived ET-1 [23,24]. These novel assays simplified the assessment of ET-1 levels and enable its determination in large population-based studies.…”

Endothelium Protective Function of Statins in Men and Women with Coronary Atherosclerosis

“…и ассоциирован с основными факторами риска ССЗ [7]. Таким образом, дисбаланс продукции эндотелина мо-жет свидетельствовать об ЭД и о других ассоциирован-ных нарушениях, детерминирующих развитие атеро-склероза, иными словами -повышенный уровень эн-дотелина мог бы выступать в роли маркера ЭД.…”