Plasma ?-endorphin and stress hormone levels during adaptation and stress

Lishmanov, Yu. B.; Trifonova, Zh. V.; Tsibin, A. N.; Maslova, L.; Dement'eva, L. A.

doi:10.1007/bf00842472

Cited by 27 publications

(21 citation statements)

References 6 publications

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“…R. rosea extracts may interact with the opioid system only under stressful conditions. Indeed, R. rosea moderates the release of the opioid peptides that occurs as part of the pituitaryadrenal axis response to stress (Lishmanov et al, 1987). In this regard, it is known that stress induces antinociception and that adaptogens, including ginseng and the related ginsenosides, reduce this effect (Choi et al, 2003;Nguyen et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…It is believed that these changes in monoamine levels are due to inhibition of the activities of the enzymes responsible for monoamine degradation (monoamine oxidase and catechol-Omethyltransferase), and to facilitation of neurotransmitter transport within the brain (Stancheva and Mosharrof, 1987). Therefore we can postulate that this antidepressant-like activity of RHO depends on its ability to enhance the catecholaminergic system (Burchfield, 1979;Lishmanov et al, 1987;Saratikov and Krasnov, 2004;Panossian and Wagner, 2005).…”

Section: Locomotor and Anxiolytic-like Activitiesmentioning

confidence: 99%

“…In this regard, it has been reported (Lishmanov et al, 1987;Maslova et al, 1994) that R. rosea can reduce the secretion of corticotrophin-releasing factor (CRF), the major physiological mediator of stress (De Souza and Grigoriadis, 1994;Koob and Heinrichs, 1999). CRF also exerts an anxiogenic activity (Dunn and Berridge, 1990).…”

Section: Locomotor and Anxiolytic-like Activitiesmentioning

confidence: 99%

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Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Perfumi

Mattioli

2006

Phytotherapy Research

150

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Rhodiola rosea L., or 'golden root', is a popular plant in traditional medicine in Eastern Europe and Asia, with a reputation for improving depression, enhancing work performance, eliminating fatigue and treating symptoms of asthenia subsequent to intense physical and psychological stress. Due to these therapeutic properties, R. rosea is considered to be one of the most active adaptogenic drugs. To confirm and extend results obtained in the few preclinical and clinical studies available in English language journals, the purpose of the present study was to re-investigate the effects produced by a single oral administration of an R. rosea hydroalcohol extract (containing 3% rosavin and 1% salidroside) on the central nervous system in mice. The extract was tested on antidepressant, adaptogenic, anxiolytic, nociceptive and locomotor activities at doses of 10, 15 and 20 mg/kg, using predictive behavioural tests and animal models. The results show that this R. rosea extract significantly, but not dose-dependently, induced antidepressant-like, adaptogenic, anxiolytic-like and stimulating effects in mice. This study thus provides evidence of the efficacy of R. rosea extracts after a single administration, and confirms many preclinical and clinical studies indicating the adaptogenic and stimulating effects of such R. rosea extracts. Moreover, antidepressant-like and anxiolytic-like activities of R. rosea were shown in mice for the first time.

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Section: Discussionmentioning

confidence: 99%

Section: Locomotor and Anxiolytic-like Activitiesmentioning

confidence: 99%

Section: Locomotor and Anxiolytic-like Activitiesmentioning

confidence: 99%

See 1 more Smart Citation

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Perfumi

Mattioli

2006

Phytotherapy Research

150

View full text Add to dashboard Cite

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“…The rate of catabolism and the efficiency of the energy-supplying systems in stressed animals were evaluated by the CS/insulin ratio whose increase reflects increased intensity of catabolic processes and reduced efficiency of energy production [9,15]. The CS/insulin ratio was calculated as the ratio between the concentrations of CS and insulin expressed in percentage of their levels in the control Wistar rats, which were taken as 100% [3,9]. The damaging effects of stress reaction were assessed from changes in the activity of blood creatine phosphokinase (CPK), which was determined using Labsystems Company kits.…”

Section: Methodsmentioning

confidence: 99%

Differences between August and Wistar rats in stress reactions and in the development of adaptation to stress

et al. 1996

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Control and acutely stressed August rats have corticosterone levels 62% and 15% higher, respectively, than their Wistar counterparts, indicating that the activity of stress-mediating hypothalamic-pituitary-adrenal system in August rats is higher. On the other hand, the intensity of stress reactions and, consequently, the degree of activation of this system in August rats are 40-50% lower, as is the blood level of creatine phosphokinase. During adaptation to stress, August and Wistar rats show a similar decrease in the stress reaction and in its damaging effects. However, judging from the blood corticosterone/insulin ratio, adaptation to stress in August rats coincides with intensification of catabolic processes and a reduction in the efficiency of energy production.

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“…The OS not only wards off damaging effects of stress but also sets up an adaptation reserve of functional capabilities in the body [5].…”

Section: Abstract: Adaptation; Opioid System; Physical Exercise; Enementioning

confidence: 99%

Relationship of adaptive capabilities in athletes to the type of reaction of their opioid system to stressful physical exercise

1996

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Eleven highly skilled skiers are examined during and after prolonged exercising on a bicycle ergometer at a Vo 2 equal to 80% of the maximum. Parameters of mechanical work, Voz, plasma lactate concentration, and activity of 8-type opioid receptor ligands are recorded. The opioid system is found to develop two types of reaction to the exercise: activation in the course of work on the ergometer with a tendency toward normalization in the recovery period (Type A) or inhibition during the exercise (Type B). The reaction of Type B involved a rapid increase in the activity of the opioid system immediately after the exercise in some cases and a further fall in the activity of plasma opioids in others. Skiers with Type B reaction performed a lesser amount of work at a higher energy cost than did those with Type A. It is concluded that the latter type of reaction is more efficient than the former. Key Words: adaptation; opioid system; physical exercise; energy supplyOne important mechanism of adaptation is associated with functioning of the opioid system (OS) which participates both in stress-promoting reactions by mobilizing the appropriate neuroendocrine processes and in stress-limiting reactions by restricting overactivation of adaptation mechanisms. The OS not only wards off damaging effects of stress but also sets up an adaptation reserve of functional capabilities in the body [5].One of the most common stressors is strenuous physical activity and adaptation to it activates physiological mechanisms characteristic of stress. Study of these mechanisms during exercising has several advantages; thus, the parameters of stress are measurable, the work load is gradable, and the results are reproducible.That the OS is involved in body's reactions to stress has been demonstrated in numerous investigations. In particular, plasma concentrations of 13-enResearch Institute of Sports; National Research Center for Mental Health, Russian Academy of Medical Sciences, Moscow dorphin and enkephalins were shown to be elevated in the course of and after intensive and prolonged work [7,10,11], and opioid peptides were found to influence the synthesis and secretion during work of stress-mediating hormones such as catecholamines [10], growth hormone and prolactin [8], corticotropin and cortisol [ 11].The purpose of the present study was to establish how adaptive capabilities of the body relate to the reaction of the OS to stressful exercise. The criteria of adaptation were parameters of mechanical work (its duration and the ability to sustain its present power) and energy supply (oxygen consumption [Vo2] and lactate level in the blood during exercising).

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Plasma ?-endorphin and stress hormone levels during adaptation and stress

Cited by 27 publications

References 6 publications

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Differences between August and Wistar rats in stress reactions and in the development of adaptation to stress

Relationship of adaptive capabilities in athletes to the type of reaction of their opioid system to stressful physical exercise

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