Plasma dopamine and catecholamine levels in patients with central serous chorioretinopathy

Kobat, Sabiha Güngör; Yusufoğlu, Elif; Gül, Feride Çoban; Keser, Sinem; Kalaycı, Mehmet

doi:10.1016/j.jfo.2020.08.032

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…23,24 Although proven information on the importance of chatecolamine in CSCR is limited, their potential effects on choroidal vessels and blood flow are well known. 25 In a CSCR model created as a model in monkeys, it has been shown that damage to the choriocapillaris endothelium and the overlying RPE as a result of repeated intravenous injections of epinephrine. 21 Corticosteroids affect the transcription of many genes, including some adrenergic receptors.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of retinal and choroidal vascular structures in patients with anxiety disorder

Acan,

Baykan,

Karahan

2024

European Journal of Ophthalmology

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Purpose To evaluate the retinal and choroidal vascular structures in patients with anxiety disorders. Methods Thirthy-four eyes of 34 patients who were diagnosed with any anxiety disorders were compared with 32 eyes of 32 age- and sex-matched controls. Central macular thickness (CMT), foveal vascular zone (FAZ) area, total retinal vascular densities of superficial and deep capillary plexus (VDSCP, VDDCP), outer retinal and choriocapillary layers (ORL, CCL) blood flow rates, central subfoveal choroidal thickness (SFCT) and choriodal vascularity index (CVI) were evaluated with optical coherence tomography angiography (OCT-A) and enhanced depth imaging optical coherence tomography (EDI-OCT). Results No statistical differences were found between the study and control groups in terms of CMT, FAZ area, VDSCP, VDDCP, ORL and CCL blood flow rates. The mean SFCT was 346.26 ± 64.26 µm in patients with anxiety disorder and was found to be statistically significantly thicker than the control group (319.56 ± 37.19 µm) ( p = 0.042). Besides, CVI was significantly lower in the study group (71.09 ± 2.64 vs 73.13 ± 3.31, p = 0.008). Conclusion In people with anxiety disorders, the SFCT was found to be thicker and CVI was found to be lower than normal subjects. Although anxiety and stress are important factors in central serous chorioretinopathy, multifactorial factors, including ocular factors, play a role in the pathophysiology of the disease. There is a need for prospective studies with larger series on the subject.

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Section: Discussionmentioning

confidence: 99%

Evaluation of retinal and choroidal vascular structures in patients with anxiety disorder

Acan,

Baykan,

Karahan

2024

European Journal of Ophthalmology

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Study on the relationship between the choroidal thickness and hormone levels with central serous chorioretinopathy

Shen

Xie

Cai

et al. 2023

Preprint

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Objective To investigate whether the choroidal thickness in central serous chorioretinopathy is related to endogenous hormone levels. Methods A case-control study. From July 2020 to October 2021, 60 male patients diagnosed with central serous chorioretinopathy at the ophthalmology clinic of the affiliated Hospital of Zunyi Medical University, and 60 healthy, young and middle-aged men were collected as the control group. There were 53 cases of acute CSC (106 eyes) and 7 cases of chronic CSC (14 eyes). The study and control groups' smoking, drinking, and sleeping habits were compared statistically, and BCVA, intraocular pressure, and eye axis were assessed. The macular choroidal thickness was measured by enhanced depth imaging-optical coherence tomography (EDI-OCT) from 2 to 5 p.m, measured at the subfoveal choroidal thickness (SFCT), above the fovea, below, nasal and temporal 750 μm, and the average macular choroidal thickness was the average of the five sites. Blood samples were taken from the control and study groups corresponding to the measuring time, and the levels of adrenaline, norepinephrine, dopamine, cortisol, aldosterone, total testosterone and estradiol were measured by radioimmunoassay. The Chi-square test was used in univariate analysis. Spearman correlation analysis was used to analyze the correlation between continuous numerical variables which did not obey normal distribution. The independent variables of p value < 0.05 in univariate analysis were included in multiple linear regression analysis. Results 1. There was no significant difference in age, smoking, drinking and sleep habits between the study group and the control group (p=0.053, 0.099, 0.079, 0.095). 2. There were significant differences in the average choroidal thickness between the affected eyes and the contralateral eyes in the study group and the control group (p＜0.05). There was no significant difference in the average macular choroidal thickness between the affected eyes and the contralateral eyes in the study group (p>0.05). 3. The levels of norepinephrine and total testosterone in the study group were significantly different from those in the control group (p< 0.05). 4. There was a positive correlation between the average macular choroidal thickness and norepinephrine and total testosterone (p<0.001, r=0.348, r=0.446). Conclusion Average choroidal thickness in macular area of CSC eyes and contralateral eyes increased. Norepinephrine and total testosterone are the main factors affecting the average choroidal thickness in macular area of CSC.

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Clinical Profile and Risk Factors of Central Serous Chorioretinopathy in Al- Ain, United Arab Emirates

Jain

Kurian

Lal

et al. 2022

NEMJ

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Background: Based on the adverse event reporting system, the authors observed unique occupational and pharmacological trends in central serous chorioretinopathy (CSC); despite being a common condition in the region, there are no large epidemiological studies. Objective: To describe the clinical profile, risk factors and co-medications of CSC in a multispecialty hospital in UAE. Methods: Hospital based retrospective, observational study in which all the confirmed cases of CSC (272) seen between 2010 and 2019 were included. Supplementary data was collected on follow up visits or through telephonic calls. Results: The male: female ratio was 17:1; low socio-economic status was (155; 73.45%), and occupations such as drivers (61; 28.9%) and outdoor laborers (59; 27.96%) were the most commonly affected. The majority (78.05%; 185) were single expatriates. Financial worries (105; 50.72%) constituted the leading cause of stress. The usage of corticosteroids (83; 30.51%), nasal decongestants (14.70%) or both (17; 6.25%) within one year was common; mostly (82; 30.14%) for rhinitis/respiratory states, though grossly under-recognized. Muscle relaxants and psychotropic medications were the other major medications used by 24 (8.82%) and 25 (9.19%) cases prior to CSC. Seven of 15 women had at least one condition that alters the endocrinal milieu: Pregnancy (3), recent child birth (1), erratic oral contraceptive intake (1), menopause with liver dysfunction (1), hormone replacement therapy for menopause and endometriosis (1), ovarian cyst and infertility (1) hypothyroidism (3), and Cushing syndrome (1). Chronic/ recurrent forms were seen in 31.08%. There were too few glaucoma patients despite both CSC and glaucoma being common among our patients. Conclusions: CSC in Al-Ain predominantly affected males with a specific occupational predisposition. Emotional distress, financial worries, allergic disorders, and endocrinal disorders (among females) were common. Adverse drug events were under-reported compared to the usage of steroid or decongestant users. Suspected pharmacological associations included drugs that modulated the vasomotor tone.

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Plasma dopamine and catecholamine levels in patients with central serous chorioretinopathy

Cited by 3 publications

References 19 publications

Evaluation of retinal and choroidal vascular structures in patients with anxiety disorder

Evaluation of retinal and choroidal vascular structures in patients with anxiety disorder

Study on the relationship between the choroidal thickness and hormone levels with central serous chorioretinopathy

Clinical Profile and Risk Factors of Central Serous Chorioretinopathy in Al- Ain, United Arab Emirates

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