Plasma dispositions and concentrations of ivermectin in eggs following treatment of laying hens

Çirak, Veli Yılgör; Akşit, Dilek; Cihan, Hüseyin; Gökbulut, Cengiz

doi:10.1080/00480169.2018.1426504

Cited by 10 publications

(16 citation statements)

References 13 publications

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“…The same dose of ivermectin (0.2 mg/kg) was administered to six birds via oral gavage using a needleless syringe. The dose of 0.2 mg/kg was based on Cirak et al [ 25 ]. The remaining four chickens were assigned to a control group that received a water gavage.…”

Section: Methodsmentioning

confidence: 99%

Systemic veterinary drugs for control of the common bed bug, Cimex lectularius, in poultry farms

et al. 2022

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Background The common bed bug, Cimexlectularius L., is a hematophagous ectoparasite that was a common pest in poultry farms through the 1960s. Dichlorodiphenyltrichloroethane (DDT) and organophosphates eradicated most infestations, but concurrent with their global resurgence as human ectoparasites, infestations of bed bugs have been reappearing in poultry farms. Although the impact of bed bugs on chicken health has not been quantified, frequent biting and blood-feeding are expected to cause stress, infections and even anemia in birds. Bed bug control options are limited due to the sensitive nature of the poultry environment, limited products labeled for bed bug control and resistance of bed bug populations to a broad spectrum of active ingredients. Veterinary drugs are commonly used to control endo- and ectoparasites in animals. In this study, we evaluated the effects of two common veterinary drugs on bed bugs by treating the host with systemic antiparasitic drugs. Methods We conducted dose–response studies of ivermectin and fluralaner against several bed bug strains using a membrane feeding system. Also, different doses of these drugs were given to chickens and two delivery methods (topical treatment and ingestion) were used to evaluate the efficacy of ivermectin and fluralaner on bed bug mortality. Results Using an artificial feeding system, both ivermectin and fluralaner caused high mortality in insecticide-susceptible bed bugs, and fluralaner was found to be effective on pyrethroid- and fipronil-resistant bed bugs. Ivermectin was ineffective in chickens either by the topical treatment or ingestion, whereas bed bugs that fed on chickens which had ingested fluralaner suffered high mortality when feeding on these chickens for up to 28 days post treatment. Conclusions These findings suggest that systemic ectoparasitic drugs have great potential for practical use to control bed bug infestations in poultry farms. These findings also demonstrate the efficacy of fluralaner (and potentially other isoxazolines) as a potent new active ingredient for bed bug control. Graphical Abstract

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Section: Methodsmentioning

confidence: 99%

Systemic veterinary drugs for control of the common bed bug, Cimex lectularius, in poultry farms

et al. 2022

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“…One cause is the difference of pharmacokinetics of MLs in birds and mammals. It has been demonstrated that a fairly low IVM concentration in plasma was obtained when it was orally administrated to laying hens [38, 39]. The other possible reason is the different sensitivity of blood-sucking PRMs and mammals’ mites to MLs.…”

Section: Discussionmentioning

confidence: 99%

Acaricidal efficacy of orally administered macrocyclic lactones against poultry red mites (Dermanyssus gallinae) on chicks and their impacts on mite reproduction and blood-meal digestion

Wang

Zhang

et al. 2019

Parasites Vectors

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Background The poultry red mite (PRM), Dermanyssus gallinae , is one of the most economically deleterious threats to laying-hen industry worldwide. Macrocyclic lactones (MLs) have been widely used in control of mites in mammals, but the effects of MLs on PRMs are not well studied. The main objective of the present study was to systematically evaluate the effects of three MLs, i.e. eprinomectin (EPR), moxidectin (MOX) or ivermectin (IVM), on PRMs fed on chicks following oral administration. Methods Chicks in treatment groups were orally administrated with EPR, MOX or IVM at a dose of 5.0 mg/kg bodyweight. Chicks in the control group received the carrier solvent without drug. Chicks in each cage were then infested with 200 starved adult D. gallinae . After infestation and feeding for 12 h, engorged mites were collected to evaluate the acaricidal efficacy of the MLs, and its impacts on the reproduction and blood-meal digestion of D. gallinae . Results MOX, IVM and EPR demonstrated higher acaricidal efficacies post-treatment compared with the control, i.e. 45.60% for MOX, 71.32% for IVM and 100% for EPR on Day 10. MLs did not have significant effects on the blood-meal ingestion of PRMs, but significantly slowed down blood digestion ( P < 0.0001). The oviposition rate, egg hatching rate and fecundity of PRMs in treatment groups were remarkably reduced. Among the three MLs, EPR exhibited the highest performance against PRMs, with an oviposition rate of 1.04%, fecundity of 0.33 eggs per mite and a zero egg hatching rate in EPR treated groups. Conclusions EPR, MOX or IVM administrated orally to chicks increased the mortality of D. gallinae , significantly slowed down their blood-meal digestion and significantly reduced their reproductive capability which included the oviposition rate, fecundity and egg hatching rate. The present study highlights the potential of MLs in the control of PRMs.

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“…The residues of ivermectin (IVM) and other macrocyclic lactones preferentially accumulate in the egg yolk following administration to laying hens (Keukens et al, 2000). Accordingly, it was reported that no IVM residues were found in egg white, which contains fat at trace levels, whereas significant IVM residues were measured in egg yolk, which is very rich in lipids, for 5 and 15 days following administration in water for 5 days (Moreno et al, 2015) and single oral administration (Cirak et al, 2018) of IVM, respectively, to laying hens.…”

Section: Discussionmentioning

confidence: 99%

“…SPN (spinosyn A and D) were also analyzed by HPLC with photodiode array (PDA) detector following an SPE procedure similar to the method used to analyze ABM with small modifications, as described below. Previous studies indicated that macrocyclic lactones, including ivermectin, were not detected in egg white (Keukens et al, 2000;Moreno et al, 2015;Cirak et al, 2018) after analysis of egg yolk and white separately. For this reason, only egg yolks were used for HPLC analysis.…”

Section: Analytical Proceduresmentioning

confidence: 97%

“…The egg, tissue and plasma concentrations of ABM were analyzed by High Performance Liquid Chromatography (HPLC) with fluorescence detector following solid phase extraction (SPE) procedure according to Cirak et al (2018). SPN (spinosyn A and D) were also analyzed by HPLC with photodiode array (PDA) detector following an SPE procedure similar to the method used to analyze ABM with small modifications, as described below.…”

Section: Analytical Proceduresmentioning

confidence: 99%

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The residue levels of spinosad and abamectin in eggs and tissues of laying hens following spray application

et al. 2019

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Spinosad (SPN) and abamectin (ABM) are used in poultry premises to control external parasites including red mites (Dermanyssus gallinae). This study aimed to determine levels of SPN (spinosyn A + spinosyn D) and ABM residues in egg and edible tissues of laying hens following spray application. A total of 36 laying hens were divided into four groups of nine birds each, and they were kept in individual cages. Two different concentrations of SPN (2 and 4 g/l) and ABM (0.025 and 0.033 g/l) were applied in stocked and empty cages, respectively. Eggs were collected individually for 30 days. All hens were sacrificed at day 30 post-treatment, and tissue samples (liver, breast muscle, fat and skin) were collected. The residue levels in eggs and tissues were determined by high pressure liquid chromatography. ABM residues were not detectable in egg samples. SPN residues in eggs and residues of both ABM and SPN in liver, muscle and fat were under the maximum residue limits (MRLs) following low and high concentration applications. However, although the MRLs have not been established for SPN and ABM in skin tissue of chicken, residues in the skin detected at the low and high concentrations were greater than the MRLs for other edible tissues (except fat tissue) indicating that a withdrawal period would be necessary for the skin tissue after ABM and SPN use in laying hens.

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Plasma dispositions and concentrations of ivermectin in eggs following treatment of laying hens

Cited by 10 publications

References 13 publications

Systemic veterinary drugs for control of the common bed bug, Cimex lectularius, in poultry farms

Systemic veterinary drugs for control of the common bed bug, Cimex lectularius, in poultry farms

Acaricidal efficacy of orally administered macrocyclic lactones against poultry red mites (Dermanyssus gallinae) on chicks and their impacts on mite reproduction and blood-meal digestion

The residue levels of spinosad and abamectin in eggs and tissues of laying hens following spray application

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