Plasma‐Derived Nanoclusters for Site‐Specific Multimodality Photo/Magnetic Thrombus Theranostics

Liu, Chia‐Hung; Liu, Ming‐Che; Jheng, Pei‐Ru; Yu, Jiashing; Fan, Yu‐Jui; Liang, Jia‐Wei; Hsiao, Yu‐Cheng; Chiang, Chih‐Wei; Bolouki, Nima; Lee, Jyh‐Wei; Hsieh, Jang‐Hsing; Mansel, Bradley W; Chen, Yan‐Ting; Nguyen, Hieu Trung; Chuang, Er‐Yuan

doi:10.1002/adhm.202301504

Cited by 8 publications

(2 citation statements)

References 97 publications

(86 reference statements)

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“…In the mouse model of thrombosis, the residual thrombus formation was reduced by 80% under NIR irradiation and magnetic guidance, and there was no risk of re-embolism. There is a clear prospect for treating life-threatening cardiovascular diseases [48]. Magnetic nanoparticles, visualized by MRI, can be integrated with clinical imaging modalities for precise localization of thrombus locations.…”

Section: Targeted Drug Delivery Of Magnetic Nanomaterialsmentioning

confidence: 99%

Advances in Nano-Functional Materials in Targeted Thrombolytic Drug Delivery

Ren,

Mi,

Wei

et al. 2024

Molecules

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Thrombotic disease has been listed as the third most fatal vascular disease in the world. After decades of development, clinical thrombolytic drugs still cannot avoid the occurrence of adverse reactions such as bleeding. A number of studies have shown that the application of various nano-functional materials in thrombus-targeted drug delivery, combined with external stimuli, such as magnetic, near-infrared light, ultrasound, etc., enrich the drugs in the thrombus site and use the properties of nano-functional materials for collaborative thrombolysis, which can effectively reduce adverse reactions such as bleeding and improve thrombolysis efficiency. In this paper, the research progress of organic nanomaterials, inorganic nanomaterials, and biomimetic nanomaterials for drug delivery is briefly reviewed.

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Section: Targeted Drug Delivery Of Magnetic Nanomaterialsmentioning

confidence: 99%

Advances in Nano-Functional Materials in Targeted Thrombolytic Drug Delivery

Ren,

Mi,

Wei

et al. 2024

Molecules

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“…Such extended-distance transmission of light carries substantial possibilities for biological medical applications necessitating deep light penetration, such as deep tissue diagnosis as well as imaging. Other functional photonic/optical-based biomaterials were developed and applied in the theragnostic vascular diseases [143][144][145][146][147][148][149], urinary system [150], anticancer/translational medicine/characterizations [114,[151][152][153][154], and regenerative medicine applications [145,[155][156][157][158].…”

Section: Cell-constructed Biologically Photonic Waveguidesmentioning

confidence: 99%

Biological Photonic Devices Designed for the Purpose of Bio-Imaging with Bio-Diagnosis

Chuang,

Yu,

Hung

et al. 2023

Photonics

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The rapid progress in the fields of biomedical and biological photonic sciences has given rise to a substantial demand for biological photonic structures capable of interacting with living systems. These structures are expected to facilitate precise manipulation of incident light at small scales, enabling the detection of sensitive biological signals and the achievement of highly accurate cell structural imaging. The concept of designing biological photonic devices using innate biomaterials, particularly natural entities such as cells, viruses, and organs, has gained prominence. These innovative devices offer the capability of multimodal light manipulation at specific sites, enhancing biological compatibility while minimizing disruptions to the delicate biological microenvironment. This article delves into recent advancements within the realm of biological photonic devices, with a dedicated focus on their applications in bio-imaging and -diagnosis. The central theme revolves around devices derived from biological entities possessing the requisite optical properties, biocompatibility, biofunctionality, and the ability to induce biological effects. These devices encompass a diverse range of optical functionalities, including light generation, transportation, and modulation, all of which play pivotal roles in bio-detection and imaging, thereby contributing notably to the advancement of these fields. The potential future directions and opportunities for the enhancement of biological photonic devices were outlined.

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Phototactic/Photosynthetic/Magnetic‐Powered Chlamydomonas Reinhardtii‐Metal‐Organic Frameworks Micro/Nanomotors for Intelligent Thrombolytic Management and Ischemia Alleviation

Chiang,

Liu,

Rethi

et al. 2024

Adv Healthcare Materials

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Thrombosis presents a critical health threat globally, with high mortality and incidence rates. Clinical treatment faces challenges such as low thrombolytic agent bioavailability, thrombosis recurrence, ischemic hypoxia damage, and neural degeneration. This study developed biocompatible Chlamydomonas Reinhardtii micromotors (CHL) with photo/magnetic capabilities to address these needs. These CHL micromotors, equipped with phototaxis and photosynthesis abilities, offer promising solutions. A core aspect of this innovation involves incorporating polysaccharides (glycol chitosan (GCS) and fucoidan (F)) into ferric Metal‐organic frameworks (MOFs), loaded with urokinase (UK), and subsequently self‐assembled onto the multimodal CHL, forming a core‐shell microstructure (CHL@GCS/F‐UK‐MOF). Under light‐navigation, CHL@GCS/F‐UK‐MOF is shown to penetrate thrombi, enhancing thrombolytic biodistribution. Combining CHL@GCS/F‐UK‐MOF with the magnetic hyperthermia technique achieves stimuli‐responsive multiple‐release, accelerating thrombolysis and rapidly restoring blocked blood vessels. Moreover, this approach attenuates thrombi‐induced ischemic hypoxia disorder and tissue damage. The photosynthetic and magnetotherapeutic properties of CHL@GCS/F‐UK‐MOF, along with their protective effects, including reduced apoptosis, enhanced behavioral function, induced Heat Shock Protein (HSP), polarized M2 macrophages, and mitigated hypoxia, are confirmed through biochemical, microscopic, and behavioral assessments. This multifunctional biomimetic platform, integrating photo‐magnetic techniques, offers a comprehensive approach to cardiovascular management, advancing related technologies.

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Plasma‐Derived Nanoclusters for Site‐Specific Multimodality Photo/Magnetic Thrombus Theranostics

Cited by 8 publications

References 97 publications

Advances in Nano-Functional Materials in Targeted Thrombolytic Drug Delivery

Advances in Nano-Functional Materials in Targeted Thrombolytic Drug Delivery

Biological Photonic Devices Designed for the Purpose of Bio-Imaging with Bio-Diagnosis

Phototactic/Photosynthetic/Magnetic‐Powered Chlamydomonas Reinhardtii‐Metal‐Organic Frameworks Micro/Nanomotors for Intelligent Thrombolytic Management and Ischemia Alleviation

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