Plasma deposition modified nylon 4 membranes for hemodialysis

Abstract

SYNOPSISThe purpose of this research is to prepare high solute permeability membranes for hemodialysis by plasma depositing hydrophilic monomers onto chemically treated or O2 plasma etched Nylon 4 substrate. The factors that affect the performances of membranes, such as deposition conditions and chemical or plasma etching conditions, were studied. The monomers used in this study were 1-vinyl-2-pyrrolidone ( V P ) , 2-Hydroxyethyl methacrylate (HEMA), and Methyl methacrylate (MMA) . The permeabilities of NaCl, urea, vitamin BIZ, and albumin were measured, as were the water content, hydration, diffusivity, partition coefficient, and protein adsorption ratio of fibrinogen to albumin by membrane surface of plasma deposited membranes. plasma modified to improve the surface energy, water content, and transport fluxes for dialysis by Lai et a1.5*6 Lai et al. used plasmas to induce hydrophilic monomers to graft onto Nylon 4 membranes for reverse osmosis desalination. Plasma deposition has been utilized to increase surface energy, plasma polymerization, etching in membrane modification, 7-9 and biomedical applications."-" Plasma polymerized surfaces are in both smooth and textured configurations, and tend to be relatively nonthrombogenic.12The purpose of this study is to improve the permeability hemodialysis and the mole ratio of adsorbed fibrinogen t o adsorbed albumin of membranes by plasma depositing the hydrophilic monomers, such as 1-Vinyl-2-pyrrolidone (VP) , 2-Hydroxyethyl methacrylate ( HEMA), and Methyl methacrylate ( MMA) , onto chemical or O2 plasma treated Nylon 4 substrate. The dialysis permeability, hydration, water content, diffusion coefficient, partition coefficient, and protein absorption ratio of fibrinogen to albumin by membrane surface of plasma deposited membranes are measured. The solutes 1431

Plasma protein adsorption and thrombus formation on surface functionalized polypyrrole with and without electrical stimulation

“…1). This ratio compares well with the ratio (3.8) reported by Lai et al for 2-hydroxyethyl methacrylate deposited Nylon 4 substrate [47]. Tsai [48] also reported that heparin immobilization on tissue induced a decrease of fibrinogen adsorption and an increase of albumin adsorption.…”

Polyvinyl Alcohol γ-Ray Grafted Nylon 4 Membrane for Pervaporation and Evapomeation

“…Nylon 4 membranes have been regarded as promising membrane materials for separation purposes because of their excellent strength and inherent affinity to water. 60Co irradiation, chemical graft, and plasma deposition methods have been used to improve the performance of Nylon 4 for reverse osmosis (19), ultrafiltration (20), dialysis (21), and hemodialysis (22) as reported from our laboratory.…”

Preparation and properties of SBS-g-DMAEMA copolymer membrane by ultraviolet radiation

“…In addition min and fibrinogen, respectively, at 30ЊC for 1 h. The to the absorption peaks associated with pure SBS block measurement of the absorption of albumin and fibrincopolymer, the SBS-g-DMAEMA graft copolymer also ogen was performed following the process described had absorption peaks at 1700 cm Ϫ1 (CuO) and at about in the literature. 18 2760 cm Ϫ1 for the third amino group. Since the unreacted DMAEMA and its homopolymer were extracted Observation by SEM with hot methanol, the presence of this absorption The membrane was soaked in liquid nitrogen until it band confirms that the SBS-g-DMAEMA was a graft hardened.…”