Plasma cystatin-C and risk of developing gestational diabetes mellitus

Yousefzadeh, Gholamreza; Pezeshki, Sara; Gholamhosseinian, Ahmad; Nazemzadeh, Mahsa; Shokoohi, Mostafa

doi:10.1016/j.dsx.2013.10.016

Cited by 10 publications

(9 citation statements)

References 23 publications

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“…Consistent with our results, recently, CysC was reported to be related to GDM in 60 pregnant women enrolled in Afzali pour hospital in Kerman, Iran. The researchers confirmed that the association between the presence of the metabolic syndrome and an increased level of CysC led to GDM[ 22 ]. In our study, Spearman’s correlation analysis confirmed the link between serum CysC and HOMA-IR.…”

Section: Discussionmentioning

confidence: 75%

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Relationship between High Serum Cystatin C Levels and the Risk of Gestational Diabetes Mellitus

Zhao

Pan

et al. 2016

PLoS ONE

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AimsSerum cystatin C (CysC) has recently been shown to be associated with the incidence of type 2 diabetes mellitus (T2DM) and progression to the pre-diabetic state. The aim of this study was to explore the relationship between serum CysC and the risk of gestational diabetes mellitus (GDM) in Chinese pregnant women.MethodsThis cross-sectional study consisted of 400 pregnant women including111 with GDM and 289 with normal glucose tolerance at 24–28 weeks of gestation. The subjects were further divided into four groups according to the CysC quartiles, and their clinical characteristics were compared. The serum CysC concentration was measured using immunoturbidimetry and the degree of insulin resistance was assessed by the homeostasis model assessment of insulin resistance (HOMA-IR).ResultsSerum CysC levels were significantly higher in pregnant women with GDM than in the healthy pregnant women[1.0(0.8–1.8) vs 0.7(0.6–1.0), P<0.01). The Spearman’s correlation analysis showed that serum CysC was positively associated with HOMA-IR(r = 0.118, P<0.05) and the occurrence of GDM(r = 0.348, P<0.01). The pregnant women were divided into quartiles according to their serum CysC concentrations. Compared to the first quartile, pregnant women in Q2 (OR, 2.441; P = 0.025), Q3 (OR, 3.383; P = 0.001) and Q4 (OR, 5.516; P<0.001) had higher risk of GDM after adjusted for age, BMI, HbA1c and HOMA-IR. Further, with a rise in the serum CysC, there was an increasing trend in the HOMA-IR levels (P<0.05). A binary logistic regression analysis after adjusting for other confounding variables revealed a significant and independent association between serum CysC and GDM [OR = 14.269; 95% confidence interval, 4.977–40.908, P<0.01].The receiver operating characteristic curve analysis revealed that the optimal cutoff point for serum CysC to indicate GDM was 0.95mg/L.ConclusionsSerum CysC is significantly and independently associated with insulin resistance and GDM. It may be a helpful biomarker to identify the risk of GDM in Chinese pregnant women.

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Section: Discussionmentioning

confidence: 75%

“…Recently, Yousefzadeh G[ 22 ] reported that CysC could be a reliable, useful and promising marker of GDM in a study enrolling 60 pregnant women (30 women with GDM and 30 healthy pregnant women). Hong Liu et al also revealed that CysC was correlated with GDM but not with the fetal outcome in 76 GDM women[ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between High Serum Cystatin C Levels and the Risk of Gestational Diabetes Mellitus

Zhao

Pan

et al. 2016

PLoS ONE

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“… 11 β2-MG and cystatin C are reliable and important markers of renal damage in patients with diabetes, and they are significantly elevated compared with control subjects. 12 , 13 In women with PCOS, cystatin C may be a new strategy in clinical practice for early detection of individuals who are at high risk for long-term metabolic and cardiovascular events. 14 …”

Section: Introductionmentioning

confidence: 99%

Increased risk markers in women with polycystic ovary syndrome and gestational diabetes mellitus during mid-pregnancy

Zhang

Wang

et al. 2020

J Int Med Res

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Objective This study aimed to investigate application of the urine albumin-to-creatinine ratio (ACR), serum beta 2-microglobulin (β2-MG), and cystatin C as risk markers in a cohort of women with polycystic ovary syndrome (PCOS) for the incidence of gestational diabetes mellitus (GDM). Methods In this cross-sectional study, we analyzed 312 pregnant women with PCOS and classified them as those with and without GDM. For all participants, elbow venous blood and clean middle urine were collected in the morning after 8 hours of an empty stomach. Results Logistic regression analysis showed that the ACR, urine β2-MG levels, and serum cystatin C levels were important markers for women with PCOS concomitant with GDM. Receiver operating characteristic curve analysis showed that the area under the curve of CysC was 0.81 with the threshold based on >0.93 and that of β2-MG was 0.72 with the threshold based on >1.25. Conclusions Increased levels of β2-MG and cystatin C and a high ACR might be risk factors for Chinese women with PCOS and GDM during mid-pregnancy.

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“…Cystatin C is considered to be a high-sensitivity marker of renal insufficiency and can also be useful in pregnancy complicated by gestational diabetes mellitus or preeclampsia [ 3 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…From the obstetric point of view, hydrolyzing of collagen in the amniotic membranes by MMP 8 can be considered as the underlying pathogenesis of premature rupture of membranes and the development of intrauterine infection [ 13 – 16 ]. Moreover, gestational diabetes mellitus, preeclampsia, and early pregnancy loss can be related to the altered expression of proteolytic enzymes in the trophoblast [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Activity of Proteolytic Enzymes and Level of Cystatin C in the Peripartum Period

Cyganek

Wyczalkowska-Tomasik

Jarmużek

et al. 2016

BioMed Research International

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Objectives. The aim of the study was to evaluate the activity of cathepsin B, collagenases, trypsin, and plasmin and concentration of cystatin C in serum of healthy pregnant women in peripartum period. Study Design. The study group included 45 women in uncomplicated pregnancies. Blood samples were collected in four time points. Enzyme activity was measured by spectrofluorometric method. The level of cystatin C was measured using immunonephelometric method. Results. Mean activity of cathepsin B and the level of serum cystatin C were significantly higher in the study group. Collagenase activity was significantly lower in the study group than the control group. No differences in collagenase, plasmin, and trypsin activity on each day of the peripartum period were found. Conclusion. High activity of cathepsin B and increased level of cystatin C are typical for women in late pregnancy. Those levels significantly decrease after delivery which can be associated with potential role of those markers in placental separation. The insignificant changes of cystatin C level in the peripartum period seem to exclude the possibility of using cystatin C as a marker for renal insufficiency in the peripartum period but additional research is necessary to investigate the matter further.

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Plasma cystatin-C and risk of developing gestational diabetes mellitus

Cited by 10 publications

References 23 publications

Relationship between High Serum Cystatin C Levels and the Risk of Gestational Diabetes Mellitus

Relationship between High Serum Cystatin C Levels and the Risk of Gestational Diabetes Mellitus

Increased risk markers in women with polycystic ovary syndrome and gestational diabetes mellitus during mid-pregnancy

Activity of Proteolytic Enzymes and Level of Cystatin C in the Peripartum Period

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