Plasma Cystathionine and Risk of Incident Stroke in Patients With Suspected Stable Angina Pectoris

Abstract

BackgroundCystathionine is an intermediate product in the transsulfuration pathway and formed during the B6‐dependent conversion of methionine to cysteine. Elevated plasma cystathionine has been related to atherosclerosis, which is a major etiological factor for ischemic stroke. However, the role of cystathionine in stroke development is unknown. Therefore, we prospectively assessed the association of circulating levels of cystathionine with risk of total and ischemic stroke.Methods and ResultsTwo‐thousand thirty‐six patients (64% men; median age, 62 years) undergoing coronary angiography for suspected stable angina pectoris were included. Stroke cases were identified by linkage to the CVDNOR (Cardiovascular Disease in Norway) project. Hazard ratios with confidence intervals (95% confidence interval) were estimated by using Cox‐regression analyses. During 7.3 years of median follow‐up, 124 (6.1%) incident strokes were ascertained, which comprised 100 cases of ischemic stroke. There was a positive association of plasma cystathionine with risk of total stroke and ischemic stroke. Comparing the fourth versus the first cystathionine quartiles, age‐ and sex‐adjusted hazard ratios (95% confidence interval) were 2.11 (1.19–3.75) and 2.56 (1.31–4.99) for total and ischemic stroke, respectively. Additional adjustment for major stroke risk factors only slightly attenuated the associations, which tended to be stronger in patients without previous or existing atrial fibrillation at baseline (hazard ratio [95% confidence interval], 2.43 [1.27–4.65] and 2.88 [1.39–5.98] for total and ischemic stroke, respectively).ConclusionsIn patients with suspected stable angina pectoris, plasma cystathionine was independently related to increased risk of total stroke and, in particular, ischemic stroke.Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT00354081.

The Association of Circulating Amino Acids and Dietary Inflammatory Potential with Muscle Health in Chinese Community-Dwelling Older People

“…Our finding that serum cystathionine and tCys were associated with adverse muscle parameters in older subjects is novel, and might seem counterintuitive, since they are on the metabolic pathway from the essential SAA methionine to the key antioxidant tGSH. However, both cystathionine and tCys are emerging as biomarkers of adverse health in older subjects, including predicting type 2 diabetes [43], cardiovascular events [44], and mortality [45]. In the present study these SAAs also correlated with dietary inflammatory potential.…”

Profiling of Homocysteine Metabolic Pathway Related Metabolites in Plasma of Diabetic Mellitus Based on LC-QTOF-MS

“…Cyathione is a sulfur-containing amino acid. In patients with cardiovascular disease, the increase of cyclic cystathione is related to oxidative damage and endothelial dysfunction [ 34 ]. We found that cystathionine is potentially related to DM, but the specific mechanism needs further study.…”

Plant Kingdom as Source of Vitamins

“…More recently, attention was drawn to cystathionine, an intermediate product of cysteine synthesis from homocysteine by vitamin B6-dependent transsulfuration. Elevated plasma cystathionine was found to be correlated with stroke and global mortality in the context of coronary heart disease (Dhar et al 2018(Dhar et al , 2019.…”