Plasma corticosterone elevations in rats in response to consumption of concentrated sugar solutions.

Hart, Robert P.; Coover, Gary D.; Shnerson, Allan; Smotherman, William P.

doi:10.1037/h0077662

Cited by 40 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the decrease was not to basal levels, there was no significant difference between the corticosterone level when water was available and that of the isotonic saline condition, an effect indicating that normal animals drank a sufficient amount of water to reduce the stress induced by the hydrational challenge. This is consistent with the results found by Hart, Coover, Shnerson, and Smotherman (1980) that cellular dehydration caused by sucrose consumption raised corticosterone levels and that the subsequent ingestion of water accelerated the decline of corticosterone concentrations from peak levels. Grossman (1975, 1976) reported that animals with selective lesions of the zona incerta, which is often destroyed during placement of LH lesions, display regulatory deficits in response to hypertonic saline and 2-deoxy-Dglucose, but not in response to polyethylene glycol or insulin.…”

Section: Discussionsupporting

confidence: 93%

Adrenocortical response to hypertonic saline in rats with lateral hypothalamic lesions.

Veitia¹,

King²,

Levine³

1982

Journal of Comparative and Physiological Psychology

View full text Add to dashboard Cite

Plasma corticosterone levels were used to assess the response to stress induced by intraperitoneal injections of hypertonic saline in rats with lateral hypothalamic (LH) or sham lesions. Rats with LH lesions displayed a corticosterone response equal to that of normal animals under basal conditions, after control injections of isotonic saline, and 20 min after injection of hypertonic saline (1.5 M, 1.0 ml/100 g of body weight). The corticosterone response of animals with LH lesions, however, was significantly less than that of normal animals 90 min after injection of hypertonic saline when no water was available. With access to water, normal animals displayed substantial drinking (14.5 ml/90 min), which resulted in a reduction in plasma corticosterone concentrations to a level observed after a control injection of isotonic saline, but the little water ingested by animals with LH lesions (2.5 ml) had no effect on the pituitary-adrenal system. It is concluded that the failure of animals with LH lesions to drink following a hydrational challenge is not the result of an exaggerated response to stress.

show abstract

Section: Discussionsupporting

confidence: 93%

Adrenocortical response to hypertonic saline in rats with lateral hypothalamic lesions.

Veitia¹,

King²,

Levine³

1982

Journal of Comparative and Physiological Psychology

View full text Add to dashboard Cite

show abstract

“…This effect might be a regulatory mechanism to prevent even higher levels of circulating glucose resulting from corticosteroneinduced glycogenolysis or gluconeogenesis. In contrast, some rodent studies have reported that sucrose or fructose increases circulating corticosterone (Hart et al 1980, Gaysinskaya et al 2011, Choi et al 2017. However, these studies examined the effects of acute or short-term sucrose consumption and all focused on male rodents.…”

Section: Journal Of Endocrinologymentioning

confidence: 99%

Sucrose consumption alters steroid and dopamine signalling in the female rat brain

Tobiansky

Kachkovski

Enos

et al. 2020

Journal of Endocrinology

View full text Add to dashboard Cite

Sucrose consumption is associated with type 2 diabetes, cardiovascular disease, and cognitive deficits. Sucrose intake during pregnancy might have particularly prominent effects on metabolic, endocrine, and neural physiology. It remains unclear how consumption of sucrose affects parous females, especially in brain circuits that mediate food consumption and reward processing. Here, we examine whether a human-relevant level of sucrose before, during, and after pregnancy (17–18 weeks total) influences metabolic and neuroendocrine physiology in female rats. Females were fed either a control diet or a macronutrient-matched, isocaloric sucrose diet (25% of kcal from sucrose). Metabolically, sucrose impairs glucose tolerance, increases liver lipids, and increases a marker of adipose inflammation, but has no effect on body weight or overall visceral adiposity. Sucrose also decreases corticosterone levels in serum but not in the brain. Sucrose increases progesterone levels in serum and in the brain and increases the brain:serum ratio of progesterone in the mesocorticolimbic system and hypothalamus. These data suggest a dysregulation of systemic and local steroid signalling. Moreover, sucrose decreases tyrosine hydroxylase (TH), a catecholamine-synthetic enzyme, in the medial prefrontal cortex. Finally, sucrose consumption alters the expression pattern of FOSB, a marker of phasic dopamine signalling, in the nucleus accumbens. Overall, chronic consumption of sucrose at a human-relevant level alters metabolism, steroid levels, and brain dopamine signalling in a female rat model.

show abstract

“…The pituitary adrenal system is a highly sensitive index of environmental change (Hennessy & Lcvine 1979) and is activated by a broad range of stimuli (Hart, Coover, Shnerson & Smotherman 1980;Coover, Satterfield, Smotherman, Steinkc & Dorsa 1983). Goldman, Coover, and Levine (1973) have demonstrated, however, that this system is capable of bidirectional shifts.…”

Section: Pituitary-adrenal System Involvement In Conditioned Immune Cmentioning

confidence: 99%

CNS–immune system interactions: Conditioning phenomena

1985

View full text Add to dashboard Cite

Converging data from different disciplines indicate that central nervous system processes are capable of influencing immune responses. This paper concentrates on recent studies documenting behaviorally conditioned suppression and enhancement of immunity. Exposing rats or mice to a conditioned stimulus previously paired with an immunomodulating agent results in alterations in humoral and cell-mediated immune responses to antigenic stimuli, and unreinforced reexposures to the conditioned stimuli result in extinction of the conditioned response. Although the magnitude of such conditioning effects has not been large, the phenomenon has been independently verified under a variety of experimental conditions. The biological impact of conditioned alterations in immune function is illustrated by studies in which conditioning operations were applied in the pharmacotherapy of autoimmune disease in New Zealand mice. In conditioned animals, substituting conditioned stimuli for active drugs delays the onset of autoimmune disease relative to nonconditioned animals using a dose of immunosuppressive drug that, by itself, is ineffective in modifying the progression of disease. The hypothesis that such conditioning effects are mediated by elevations in adrenocortical steroid levels receives no support from available data. Despite its capacity for self-regulation, it appears that the immune system is integrated with other psychophysiological processes and subject to modulation by the brain.

show abstract

Plasma corticosterone elevations in rats in response to consumption of concentrated sugar solutions.

Cited by 40 publications

References 16 publications

Adrenocortical response to hypertonic saline in rats with lateral hypothalamic lesions.

Adrenocortical response to hypertonic saline in rats with lateral hypothalamic lesions.

Sucrose consumption alters steroid and dopamine signalling in the female rat brain

CNS–immune system interactions: Conditioning phenomena

Contact Info

Product

Resources

About