Plasma Concentrations of Platelet-Specific Proteins in Different Stages of Essential Hypertension: Interactions between Platelet Aggregation, Blood Lipids and Age

Yamanishi, Junji; Sano, Hiroshi; Saito, Komei; Furuta, Yutaka; Fukuzaki, Hisashi

doi:10.1055/s-0038-1657892

Cited by 36 publications

(14 citation statements)

References 32 publications

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“…In a considerable number of the patients (35.7%) we found an enhanced in vitro reactivity towards ADP (2 μιηοΙ/Ο-ίικΚκκα aggregation, which is in agreement with earlier fmdings of Yamanishi et al (24) in patients with different stages of essential hypertension. One could speculate that this phenomenon is a sequal of the diminished prostacyclin synthesis and/or release by the endothelial cells.…”

Section: Discussionsupporting

confidence: 92%

Plasma Concentration of Coagulation and Fibrinolysis Factors and Platelet Function in Hypertension

Wersch

Rompelberg-Lahaye²,

Lustermans³

1991

Clinical Chemistry and Laboratory Medicine

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Summary:Fifty-one patients with mild hypertension were evaluated in relation to the plasma concentrations of coagulation and fibrinolysis factors äs well äs for the aggregability of their platelets.In a considerable number of the patients (18/51), a significantly enhanced in vitro ADP aggregation was found. In the coagulation line significant increases could be demonstrated in fibrinogen, fibrin monomers and thrombin-antithrombin III. The fibrinolysis System showed significant increases for Ddimers, tissue plasminogen activator antigen and plasminogen activator Inhibitor, whereas the tissue plasminogen activator activity was significantly diminished. Remarkably, there seems to be a discrepancy between the (low) tissue plasminogen activator activity and the (higher) plasminogen activator antigen concentration.Alterations in the plasma concentrations of the investigated coagulation and fibrinolysis factors and in the aggregability of the platelets are indicative of an involvement of coagulation, fibrinolysis and platelets in hypertension, which can be considered äs partial risk factors for thrombophilia.

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Section: Discussionsupporting

confidence: 92%

Plasma Concentration of Coagulation and Fibrinolysis Factors and Platelet Function in Hypertension

Wersch

Rompelberg-Lahaye²,

Lustermans³

1991

Clinical Chemistry and Laboratory Medicine

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“…53 However, even this finding was not confirmed by others. 19 Our study, in addition, showed that the plasma /3-thromboglobulin concentration was independent of the level of blood pressure elevation and the duration of hypertension.…”

Section: Fi-thromboglobulin Blood Pressure and Platelet Activationsupporting

confidence: 51%

“…A positive correlation has been reported with platelet aggregation in patients with uncomplicated essential hypertension. 1418 However, Yamanishi et al 19 were unable to confirm this finding in 116 male patients with untreated essential hypertension.…”

mentioning

confidence: 95%

Platelet calcium and quenched-flow aggregation kinetics in essential hypertension.

1989

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Abnormal platelet function may contribute to the complications of essential hypertension. We have studied the kinetics of platelet aggregation induced by adenosine diphosphate (ADP) or epinephrine, plasma 0-thromboglobulin, and basal, cytosolic, and free calcium, as correlates of platelet function. Fifteen untreated patients with essential hypertension and without detectable atherosclerosis, 18-40 years old, were compared with 30 matched normotensive control subjects. Maximal rates of platelet aggregation ( V J with ADP and epinephrine were significantly higher in patients than in control subjects (p<0.03), as assessed by quenched-flow aggregometry. However, significance was lost when V,., was corrected for the platelet count. Paradoxically, the activation constants (KJ for ADP were higher in patients than in control subjects (/7<0.03). With ADP as the inducing agent, onset time (t) or lag period before aggregation begins was longer in patients than in control subjects (/><0.02). /3-thromboglobulin levels, an index of in vivo platelet activation, were not significantly different between the two groups (p=0.13). The mean platelet cytosolic free calcium concentration was higher in patients (213±19 nM) than in control subjects (172±14 nM), but this difference was not statistically significant (p=0.07). However, there was a close correlation between the free calcium level and systolic, diastolic, and mean blood pressure (/?<0.003, /?<0.04, /?<0.004, respectively). No difference in platelet volume between the two groups was found. Our data suggest that platelets in the early stages of essential hypertension display an overall increased aggregation potential but a diminished sensitivity to ADP. The tendency toward elevated calcium suggests that in hypertensive patients the platelets circulate in an already activated state; this occurrence could contribute to acceleration of atherosclerosis. (Hypertension 1989;13:558-566)

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“…34 - 35 Furthermore, aggregating platelets produce greater contraction of thoracic aortas in hypertensive rats than in normotensive rats. lets may be of particular importance in the cerebral circulation.…”

Section: Discussionmentioning

confidence: 99%

Responses of cerebral arterioles to adenosine 5'-diphosphate, serotonin, and the thromboxane analogue U-46619 during chronic hypertension.

1988

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SUMMARY The goal of this study was to determine whether responses of cerebral arterioles to products released by platelets are impaired hi stroke-prone spontaneously hypertensive rats (SHRSP). The diameter of pial arterioles was measured during suffusion with adenosine 5'-diphosphate (ADP), serotonin, and the thromboxane analogue U-46619, using Intravltal microscopy in normotensive Wistar-Kyoto rats (WKY) and SHRSP ( Platelets contain large amounts of serotonin, adenosine 5'-diphosphate (ADP), and thromboxane that are released during platelet aggregation. '-3 The responses of aortic rings to products released by platelets are altered during chronic hypertension. The relaxation of thoracic aorta in response to ADP is impaired, 4 and there is enhanced sensitivity of vascular muscle to serotonin in hypertensive rats.

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Plasma Concentrations of Platelet-Specific Proteins in Different Stages of Essential Hypertension: Interactions between Platelet Aggregation, Blood Lipids and Age

Cited by 36 publications

References 32 publications

Plasma Concentration of Coagulation and Fibrinolysis Factors and Platelet Function in Hypertension

Plasma Concentration of Coagulation and Fibrinolysis Factors and Platelet Function in Hypertension

Platelet calcium and quenched-flow aggregation kinetics in essential hypertension.

Responses of cerebral arterioles to adenosine 5'-diphosphate, serotonin, and the thromboxane analogue U-46619 during chronic hypertension.

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