Plasma concentrations of PGFM and uterine and ovarian responses in early lactation dairy cows fed omega-3 and omega-6 fatty acids

Dirandeh, E.; Towhidi, Armin; Pirsaraei, Zarbakht Ansari; Hashemi, Farid; Ganjkhanlou, M.; Zeinoaldini, S.; Roodbari, A. Rezaei; Saberifar, T.; Petit, H.V.

doi:10.1016/j.theriogenology.2013.03.012

Cited by 32 publications

(34 citation statements)

References 30 publications

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“…Feeding FO did not influence uterine involution in terms of uterine diameter, wall thickness and caruncular diameter. This is in agreement with the report of Juchem (2007) and size of the dominant or preovulatory follicle in cow (Ambrose et al, 2006;Dirandeh et al, 2013a). In the cyclic goat, dietary FO increased the number of preovulatory follicle by 39.7% and ovulation rate by 41.3% (Mahla et al, 2017).…”

Section: Supplementation Of Fo During Late Gestation Increased the Epasupporting

confidence: 92%

“…A peripartum diet enriched with linoleic acid (n‐6 PUFA) increased the PGFM in first 10 days post‐partum (Cullens, ). Similarly, feeding n‐6 PUFA‐rich soybean diet from calving to day 70 post‐partum increased serum PGFM concentration and hastened uterine involution as compared to PO fed control group (Dirandeh et al, ). Feeding safflower oil (source of n‐6 PUFA) during the transition period increased serum PGFM on day 4 and 7 post‐partum in cows as compared to cow receiving PO diet (Silvestre et al, ).…”

Section: Discussionmentioning

confidence: 96%

“…This is in agreement with the report of Juchem () who reported that feeding calcium salt of long‐chain n‐6 PUFA did not affect uterine involution in cows. In contrast, feeding soybean meal (rich in n‐6 linoleic acid) diet shortened the involution by 2.8 and 3.8 days in comparison with cows supplemented with linseed and PO, respectively (Dirandeh et al, ). Most goats in the FO group (87.5%) resumed the follicular activity much earlier than goats of PO group (25%); however, no treatment effect was found on the reappearance of a follicle ≥4 mm in diameter with respect to post‐partum day.…”

Section: Discussionmentioning

confidence: 99%

“…This is supported by the early resumption of oestrus in the FO group. Supplementation of feeds rich in n‐3 PUFA such as fish meal, FO and flax seed altered the follicular dynamics in terms of follicular turn over (Petit et al, ) and size of the dominant or preovulatory follicle in cow (Ambrose et al, ; Dirandeh et al, ). In the cyclic goat, dietary FO increased the number of preovulatory follicle by 39.7% and ovulation rate by 41.3% (Mahla et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Further, feeding n‐6 PUFA‐rich diet during the pre‐partum and n‐3 PUFA‐rich diet during breeding improved the production and reproduction in the dairy cows (Silvestre et al, ). Feeding n‐6 PUFA‐rich soybean decreased the occurrence of clinical endometritis, while feeding n‐3 PUFA‐rich linseed decreased PGF 2α production following OXT challenge (Dirandeh et al, ). Since dietary n‐3 PUFA decreases the production of series 2 prostaglandins such as PGE 2 (Calder, ) and PGF 2α (Gulliver et al, ; Mattos et al, ), which are obligatory for endocrinologically regulated inflammatory events such as ovulation, luteolysis, embryo implantation, cervical ripening, parturition and involution of the uterus in farm animals (Weems et al, ), the overall benefit of supplementing n‐3 PUFA‐rich diet during late gestation in the goat needs to be investigated as compared to the risk of hampering PGF 2α production.…”

Section: Introductionmentioning

confidence: 99%

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Effect of n‐3 PUFA‐rich fish oil supplementation during late gestation on kidding, uterine involution and resumption of follicular activity in goat

Yadav

Singh

Kumar

et al. 2019

Reprod Domestic Animals

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We have shown that dietary supplementation of n‐3 polyunsaturated fatty acid (n‐3 PUFA)‐rich fish oil (FO) around the breeding time improved the utero‐ovarian functions in the goat. Here, we investigated the effect of FO supplementation during the periparturient period on serum n‐3 PUFA, prostaglandin F2α metabolite (PGFM), placental expulsion, uterine involution, resumption of oestrus and neonatal vigour. Rohilkhandi goat in advanced gestation (n = 16) was divided into two equal groups. One group was supplemented with FO containing 26% n‐3 long‐chain PUFA at the rate of 156 mg per kg body weight, while the control group was fed isocaloric palm oil (PO) from −3 to +3 week of kidding. Dietary FO increased serum concentration of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) by 7.3‐ and 6.6‐fold, respectively, after 6 weeks of supplementation. Goats in FO group expelled the foetal membranes 99.1 min earlier (p < .01) than those of PO group. Further, dietary FO significantly decreased the serum PGFM on day 7 post‐partum. However, no difference was found on uterine involution, which was complete by day 20 post‐partum in either group. Resumption of follicular activity by day 5 post‐partum was 87.5% in the FO as compared to 25% in the PO group (p < .05). Similarly, occurrence of behavioural oestrus by day 90 post‐partum was 57.1% in goats of the FO group while none of does was in the PO group (p < .01) expressed oestrus. It was concluded that feeding FO‐rich diet during −3 to +3 weeks of kidding decreased the PGFM till day 7 post‐partum, hastened the expulsion of foetal membranes and reduced the time from kidding to first post‐partum oestrus in Rohilkhandi does.

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Section: Supplementation Of Fo During Late Gestation Increased the Epasupporting

confidence: 92%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of n‐3 PUFA‐rich fish oil supplementation during late gestation on kidding, uterine involution and resumption of follicular activity in goat

Yadav

Singh

Kumar

et al. 2019

Reprod Domestic Animals

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Effect of omega‐3 polyunsaturated fatty acid supplementation on oxidative stress parameters and sex hormone levels of modern genotype sows

Roszkos

Tóth

Bázár³

et al. 2022

Veterinary Medicine & Sci

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Background Sows are exposed to severe stress and hormonal challenges during their whole productive life. As polyunsaturated fatty acids play an important role in immune and reproductive functions, with a better understanding of their role in breeding sows’ nutrition, improved performance and more sustainable pig production can be achieved. Objectives In this study, we investigated the effects of omega‐6 and omega‐3 fatty acid supplementation on the antioxidant status and hormone levels of sows. Methods A total of 48 Danish Large white × Danish Landrace sows were supplemented either with sunflower oil (SO) as a control group or with fish oil (FO) as experimental group at the same dose of 10 g/kg feed. Blood samples were collected on day 14 of lactation, 5 days after weaning (insemination), and 30 days after insemination. To estimate antioxidant and reproductive effects, the amounts of reduced glutathione (GSH), thiobarbituric acid reactive substance, the activity of glutathione peroxidase (GPx), serum 17β oestradiol (E2), progesterone (P4), and 6‐keto prostaglandin F1α (6‐keto PGF1α) levels were investigated. Results FO‐based supplementation increased GPx activity on day 14 of lactation. Five days after weaning, the concentration of GSH in FO‐fed sows was significantly higher than that in SO‐fed sows. The E2 content of blood was significantly lower in the experimental group than in the control group for two of the three examined periods (day 14 of lactation and 30 days after insemination), whereas P4 levels were significantly higher in the experimental group 5 days after weaning. We found that 6‐keto PGF1α levels were systematically lower in the experimental group throughout the trial. Conclusions This study provides evidence of the major impact of omega‐6 and ‐3 fatty acids on the tested hormone levels, which serve as precursors for the production of E2 and P4 but have an opposite effect on PGF2α production.

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Luman recruiting factor is involved in stromal cell proliferation during decidualization in mice

Lin

Chen

et al. 2016

Cell Tissue Res

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Decidualization is crucial for successful pregnancy in mice and humans. Although many essential molecular modulators have been identified during decidualization, the precise molecular mechanism of uterine decidualization remains largely unknown. Our previous research indicates that luman recruiting factor (LRF) is strongly expressed in decidual uteri of mice on days 6-8 of pregnancy. In this study, our aim is to determine the biological functions of LRF during decidualization in mice. We used the shLRF lentivirus to attenuate the expression of LRF, which significantly reduced the weight and size of implantation sites on days 7-8 of pregnancy. In a stromal cell culture model, LRF mRNA and protein levels increased significantly during stromal cell decidualization induced by estrogen and progesterone. LRF silencing resulted in the decidual markers decidual prolactin-related protein, insulin-like growth factor-binding protein 1 and progesterone receptor being dramatically reduced, and the decidual process was significantly inhibited. Cell-cycle analysis and cell apoptosis analysis revealed that, although no obvious apoptosis occurred in shLRF-lentivirus-infected stromal cells during decidualization, proliferation was inhibited via S-phase cell-cycle arrest, and the mitotic activity of uterine stromal cells was inhibited. An examination of cell-cycle regulatory factors indicated that the mRNA expression levels of cyclin A and cyclin B1 were significantly down-regulated after treatment with shLRF lentivirus. Thus, LRF seems to be involved in the regulation of decidualization during pregnancy by modulating the expression of the key cell-cycle regulatory factors cyclin A and cyclin B1.

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Plasma concentrations of PGFM and uterine and ovarian responses in early lactation dairy cows fed omega-3 and omega-6 fatty acids

Cited by 32 publications

References 30 publications

Effect of n‐3 PUFA‐rich fish oil supplementation during late gestation on kidding, uterine involution and resumption of follicular activity in goat

Effect of n‐3 PUFA‐rich fish oil supplementation during late gestation on kidding, uterine involution and resumption of follicular activity in goat

Effect of omega‐3 polyunsaturated fatty acid supplementation on oxidative stress parameters and sex hormone levels of modern genotype sows

Luman recruiting factor is involved in stromal cell proliferation during decidualization in mice

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