Plasma concentrations of atrial natriuretic peptide during physical exercise in patients with congestive heart failure

Haass, Markus; Dietz, Rainer; Purgaj, J; Lang, R.; Kübler, W.

doi:10.1007/bf01857647

Cited by 9 publications

(3 citation statements)

References 25 publications

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“…The elevated plasma ANP at rest combined with a significant increase during exercise found in the present study resembles the secretion pattern reported in exercise studies in patients with left ventricular dysfunction and CHF [22][23][24][25][26]. The mechanisms of exercise-induced increase in AF are probably similar to the mechanisms in patients with left ventricular dysfunction and CHF where Nishikimi et al [27] reported a positive correlation between pulmonary capillary wedge pressure and plasma ANP level during exercise, emphasizing the importance of left atrial pressure i.e.…”

Section: P=002supporting

confidence: 84%

Natriuretic peptide response to dynamic exercise in patients with atrial fibrillation

Engelmann

Niemann

Kanstrup

et al. 2005

International Journal of Cardiology

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Section: P=002supporting

confidence: 84%

Natriuretic peptide response to dynamic exercise in patients with atrial fibrillation

Engelmann

Niemann

Kanstrup

et al. 2005

International Journal of Cardiology

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“…Several studies have shown that the plasma levels of ANP and BNP rise during dynamic exercise, not only in healthy subjects (18), but also in patients with some cardiac pathologies, such as atrial fibrillation (8), left ventricular dysfunction, and congestive heart failure (16,25). The enhanced synthesis and release of these potent vasodilating and natriuretic agents may represent an important factor for fluid regulation, preventing cardiac hypertrophy and leading to increased lipid mobilization, functions that may significantly help obese patients.…”

Section: Discussionmentioning

confidence: 99%

Effect of exercise training on cardiac oxytocin and natriuretic peptide systems in ovariectomized rats

Gutkowska

Paquette²,

Wang³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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Exercise training results in cardiovascular and metabolic adaptations that may be beneficial in menopausal women by reducing blood pressure, insulin resistance, and cholesterol level. The adaptation of the cardiac hormonal systems oxytocin (OT), natriuretic peptides (NPs), and nitric oxide synthase (NOS) in response to exercise training was investigated in intact and ovariectomized (OVX) rats. Ovariectomy significantly augmented body weight (BW), left ventricle (LV) mass, and intra-abdominal fat pad weight and decreased the expression of oxytocin receptor (OTR), atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and guanylyl cyclase-A (GC-A), in the right atrium (RA) and LV, indicating estrogenic control of these genes. These effects of ovariectomy were counteracted by 8-wk-long exercise training which decreased fat pad weight (33.4 +/- 2.3 to 23.4 +/- 3.1 g, n = 8, P < 0.05), plasma free fatty acids (0.124 +/- 0.033 to 0.057 +/- 0.010 mM, n = 8, P < 0.01), and plasma triacylglycerol (0.978 +/- 0.174 to 0.588 +/- 0.115 mM, n = 8, P < 0.05). Chronic exercise tended to decrease BW and stimulated ANP (4- to 5-fold) and OTR gene expression in the LV and RA and BNP and inducible NOS (iNOS) mRNA in the LV. In sham-operated rats, exercise augmented ANP expression in the RA, downregulated GC-A mRNA in the LV and RA, but increased its expression threefold in the RA of OVX animals. Endothelial NOS and iNOS expression was enhanced in the left atrium of sham-operated rats. Altogether, these data indicate that in OVX animals, chronic exercise significantly enhances cardiac OT, NPs, and NOS, thus implicating all three hormonal systems in the beneficial effects of exercise training.

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“…Dynamic exercise stimulates secretion of ANP in patients with CHF, and the increase in atrial pressure and stretching of the atrium are considered to be major stimuli for ANP secretion [6, 7]. The authors [8] and others [9–16] have evaluated plasma ANP response to exercise, and found that this response is augmented in patients with symptomatic CHF, and this augmentation is not present in patients with asymptomatic left ventricular dysfunction (LVD).…”

Section: Introductionmentioning

confidence: 99%

Augmented response in plasma brain natriuretic peptide to dynamic exercise in patients with left ventricular dysfunction and congestive heart failure

Kato

Kinugawa

Oginö

et al. 2000

Journal of Internal Medicine

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Abstract. Kato M, Kinugawa T, Ogino K, Endo A, Osaki S, Igawa O, Hisatome I, Shigemasa C (Tottori University Faculty of Medicine, Yonago, Japan). Augmented response in plasma brain natriuretic peptide to dynamic exercise in patients with left ventricular dysfunction and congestive heart failure. J Intern Med 2000; 248: 309±315.Objectives. We have previously demonstrated that patients with symptomatic congestive heart failure (CHF), but not with asymptomatic left ventricular dysfunction (LVD), have augmented plasma atrial natriuretic peptide (ANP) response to exercise. Plasma brain natriuretic peptide (BNP) response to exercise is less extensively studied. The aim of this study was to determine whether responses of plasma BNP during exercise normalized for exercise workload are altered in patients with LVD and CHF. Subjects and methods. Twenty-nine patients with LVD, 32 patients with CHF (NYHA classes II±III) and 27 age-matched control subjects were studied. Ventilatory, plasma ANP and BNP responses were assessed during symptom-limited cardiopulmonary exercise testing. Plasma natriuretic peptide levels were measured at rest and immediately after peak exercise. The increment in plasma BNP was divided by the increment in oxygen uptake (VO 2 ) from rest to peak exercise, and this ratio [BNP exercise ratio: (peak BNP ± rest BNP)/(peak VO 2 ± rest VO 2 )] was compared amongst the three groups. Results. Peak VO 2 (Control, LVD and CHF: 28.2 6 1.7, 21.1 6 1.8, 16.2 6 0.6 mL min 21 kg 21 , respectively), anaerobic threshold and peak workload became smaller as heart failure worsened. Resting and peak plasma ANP levels were significantly higher only in CHF, whilst resting and peak plasma BNP levels displayed a significant and continuous increase from normal subjects to LVD and CHF. The ANP exercise ratio (1.25 6 0.36, 2.61 6 0.57, 7.72 6 1.65, ANOVA P = 0.0002) was significantly higher only in patients with CHF, whilst the BNP exercise ratio (0.35 6 0.10, 2.60 6 0.69, 4.98 6 0.97, ANOVA P = 0.0001) was significantly higher in patients with LVD and became progressively higher in patients with CHF. Conclusions. These data showed that the BNP exercise ratio, an exercise plasma BNP response normalized with exercise workload, was augmented in patients with LVD, and became progressively higher in CHF, suggesting that an augmented exercise BNP ratio exists early in the course of developing CHF.

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Plasma concentrations of atrial natriuretic peptide during physical exercise in patients with congestive heart failure

Cited by 9 publications

References 25 publications

Natriuretic peptide response to dynamic exercise in patients with atrial fibrillation

Natriuretic peptide response to dynamic exercise in patients with atrial fibrillation

Effect of exercise training on cardiac oxytocin and natriuretic peptide systems in ovariectomized rats

Augmented response in plasma brain natriuretic peptide to dynamic exercise in patients with left ventricular dysfunction and congestive heart failure

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