Plasma concentration of urotensin II is raised in hypertension

Cheung, Bmy; Leung, R; Man, Yu Bun; Wong, LC

doi:10.1097/01.hjh.0000125452.28861.f1

Cited by 146 publications

(119 citation statements)

References 15 publications

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“…Somewhat contrary are the results obtained by Rdzanek et al, who did not observe any significant differences in plasma UII concentration in myocardial infarction survivors with and without hypertension [18]. These data are inconsistent with findings of Cheung et al showing raised plasma UII concentration in patients with arterial hypertension [19].…”

Section: Discussioncontrasting

confidence: 57%

Is plasma urotensin II concentration an indicator of myocardial damage in patients with acute coronary syndrome?

Babińska¹,

Holecki²,

Prochaczek³

et al. 2012

aoms

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A b s t r a c tIntroduction: Urotensin II (UII) is a vasoactive peptide secreted by endothelial cells. Increased plasma UII concentration was observed in patients with heart failure, liver cirrhosis, diabetic nephropathy and renal insufficiency. In patients with myocardial infarction both increased and decreased plasma UII concentrations were demonstrated. The aim of this study was to analyze whether plasma UII concentration reflects the severity of acute coronary syndrome (ACS). Material and methods: One hundred and forty-nine consecutive patients with ACS, without age limit, were enrolled in the study. In all patients plasma concentration of creatinine, creatine kinase isoenzyme MB (CK-MB), troponin C, N-terminal prohormone of brain natriuretic peptide (NT-pro BNP), and UII were assessed, and echocardiography was performed in order to assess the degree of left ventricular hypertrophy, ejection fraction (EF) and mass (LVM). Results: In patients with the highest risk (TIMI 5-7) plasma UII concentration was significantly lower than in those with low risk (TIMI 1-2): 2.61 ±1.47 ng/ml vs. 3.60 ±2.20 ng/ml. Significantly lower plasma UII concentration was found in patients with increased concentration of troponin C (2.60 ±1.52 ng/ml vs. 3.41 ±2.09 ng/ml). There was a significant negative correlation between plasma UII concentration and TIMI score or concentration of troponin C, but not CK-MB. Borderline correlation between plasma UII and ejection fraction (R = 0.157; p = 0.063) or NT-proBNP (R = -0.156; p = 0.058) was found. Conclusions: Decreased plasma urotensin II concentration in patients with ACS could be associated with more severe injury of myocardium.

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Section: Discussioncontrasting

confidence: 57%

Is plasma urotensin II concentration an indicator of myocardial damage in patients with acute coronary syndrome?

Babińska¹,

Holecki²,

Prochaczek³

et al. 2012

aoms

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“…18.9 pg/ml (13.6 pM) [64] Siroz ve portal hipertansiyon 3600 pg/ml (3.6 ng/ml) 1290 pg/ml (1.29 ng/ml) (santral venöz) 1100 pg/ml (1.1 pg/ml) (portal venöz kan) [78] Renal disfonksiyon 6.11 pg/ml(4.4 fmol/ml) Diyalizsiz-iki kat artmış Diyalizli-üç kat artmış [79] Diabetes mellitus 7.22 pg/ml (5.2 fmol/ml) Kreatinin klirensi ≥ 70 ml/dk 15.13 pg/ml (10.9 fmol/ ml) Kreatinin klirensi ≥30 ml/ dk ve <70 ml/dk olanlarda 15 pg/ml (10.8 fmol/ml) Kreatinin klirensi <30ml/dk olanlarda 22.1 pg/ ml (15.9 fmol/ ml) [80] Nefrotik sendrom (çocuk) 37.31 pg/ml (remisyon dönemi) 31.09 pg/ml (relaps dönemi) [81] Son dönem böbrek yetmezliği 3100 pg/ml 6500 pg/ml (son dönem) [82] Preeklampsi 23.05 pg/ml (plazma) 21.88 pg/ml (plazma) [83] tein kinaz, ERK 1/2 ve p 38 ile ilişkili olduğu ortaya koyulmuş-tur [58]. Leonard ve arkadaşları da son yıllarda yaptığı bir çalış-mada iskemik kalp hastalığında ÜTR ekspresyonunu araştırmış ve artmış ÜTR ekspreyonunun ventriküler skar dokusu fenomeni olarak açıklanabileceğini söylemişlerdir [59] .…”

Section: Koroner Kalp Hastalığı Ve İskemik Kalp Hastalığıunclassified

“…Aynı yıllarda Cheung ve arkadaşları [64] yaptı-ğı bir çalışmada hipertansif hastaları normotansif kontrol grubu ile karşılaştırmış, plazma ÜT 2 seviyesini hipertansif hastalarda normotansif hastalara göre yüksek olarak bulmuşlar ve bunu direkt sistolik kan basıncı ile ilişkilendirmişlerdir. Mori ve arkadaşları son yıllarda yaptığı bir çalışmada [65] hipertansiyon ve kronik renal yetmezlikli hastaların böbreklerinde ÜİP ve ÜİP m RNA'sını artmış olarak bulmuş ve ÜİP ve reseptörünün bu hastalıkların patofizyolojisinde önemli role sahip olabileceğini söy-lemişlerdir.…”

Section: Sistemik Hipertansiyonunclassified

The Importence of Urotensin and Urotensin Receptors in Cardiovascular System

Köse¹

2014

Ann Clin Anal Med

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ÖzetBir siklik petid olan Ürotensin 2 (ÜT 2) yaklaşık 45 yıl önce keşfedilmiştir ve güçlü vazokonstriktör etkilerinin olmasından dolayı bilim camiası tarafından dikkat çekmiştir. ÜT 2 G proteinine bağlı bir reseptör olan "GPR14" reseptö-rüne bağlanarak etki gösterir. ÜT 2 ve reseptörü yaygın olarak periferik vasküler dokularda, kalp ve böbrekte dağılım göstermektedir. ÜT 2'nin sağlıklı insanda çok küçük bir role sahip olduğu belirtilmiş, hastalık durumlarında ise nispeten rolünün daha belirgin olduğuna değinilmiştir. ÜT 2'nin kardiyovaskü-ler etkileri insanda başlıca pozitif inotropi, vazokontsriksiyon ve vasküler yatağın ve endotelin durumuna bağlı vazodilatasyon ve vasküler düz kas hücre proliferasyonudur. Günümüzdeki araştırmalar ÜT 2'nin özellikle çeşitli kardiyovasküler hastalıklarda önemli bir rol oynadığını göstermiştir. ÜT 2 ve dolayısıyla ÜT 2 reseptörlerinin kardiyovasküler sistem üzerindeki etkileri günü-müzde oldukça çok çalışılan bir konu olmakla beraber literatürde bu konuyla ilgili çalışmalar ve bu çalışmalar sonucu elde edilen sonuçlar oldukça karı-şıktır. Kalp yetmezliğinde daha önceki çalışmalarda majör bir rol oynamadığı söylenmiş, daha sonraki çalışmalarda hastalığın patofizyolojisinde potansiyel role sahip olduğu gösterilmiştir. Ayrıca koroner kalp hastalığı ve iskemik kalp hastalığı ve aterosklerozda da ÜT 2 seviyesinin arttığı gösterilmiştir. Bu reseptörlerin fizyopatolojide mi rol oynadığı veya çok önemli bir savunma makanizması mı olduğu önemli bir araştırma konusu olmaktadır. Bu nedenle bu reseptörler bilim camiasında umut verici bir hedef olarak değerlendirilmekte-dir. Sonuç olarak bu reseptörlerin ileride çoğu hastalıkta özellikle kardiyovasküler hastalıkların gerek patofizyolojisi gerekse savunma mekanizmalarında kendilerine yer edineceğini ve daha fazla önem kazanacağını düşünmekteyiz. Anahtar KelimelerÜrotensin-2; Ürotensin Reseptörü; Endotel; Kalp Yetmezliği; Hipertansiyon Abstract Urotensin 2 (UT 2) which is a cyclic peptid was first identified about 45 years ago and due to its potent vasoconstrictor effect it has attracted the attention of the scientific community. UT 2 binds to a class of G protein-coupled receptor known as GPR14. Receptors for UT 2 are located on peripheral vascular smooth muscle, heart and kidney. In healthy people it has minor role, while in patients with disease it has a more prominent role. Main positive effects of UT 2 in cardiovasculer system are positive inotropic effect, vasoconsctruction, vascular smooth muscle cell proliferation, vasodilatation which related the state of endothelin and vascular bed. Recent investigations have showed that UT 2 plays an important role in cardiovascular diseases. Although the effects of UT 2 and UT 2 receptors on cardiovascular system is a quite extensively studied subject. The studies and the results obtained from these studies are somewhat complex. Previous studies in heart failure has demonstrated that these receptors do not play a major role in heart failure but in later studies it has been shown that these receptor...

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“…The comparison of UII to ET-1 was based on the following main lines of evidence: i) UII is the most potent mammalian vasoconstrictor (3), and its plasma concentration was found to be markedly elevated in hypertensive subjects (10,36) and in patients with congestive heart failure (37-40); ii) high UII expression has been detected in coronary atherosclerotic lesions (16,41). Taken together, these observations, coupled to the demonstration that UII induces cardiomyocyte hypertrophy (42,43) and cardiac fibrosis (8,44), led to the conclusion that this peptide, such as ET-1 (45,46), may play a deleterious role in the progression of CV diseases (9)(10)(11)(12).…”

Section: Discussionmentioning

confidence: 99%

Urotensin-II and UII-receptor expression and function in the rat adrenal cortex

Albertin

Casale²,

Ziółkowska³

et al. 2006

Int J Mol Med

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Abstract. Urotensin-II (UII) is a potent hypertensive peptide, which has been recognized as an endogenous ligand of the G protein-coupled receptor (GPR)-14, now named UT-R. Real-time PCR demonstrated the expression of UII and UT-R mRNAs in both dispersed and in vitro cultured rat adrenocortical cells. UII concentration-dependently decreased basal, but not ACTH-stimulated, corticosterone secretion from cultured adrenocortical cells, and the effect was abolished by the UT-R antagonist Palosuran. UII did not affect the proliferation rate of cultured cells. Taken together, these findings suggest that UII may be included in the group of peptides (adrenomedullin, atrial natriuretic peptide, neurotensin and beacon), that, acting in an autocrine-paracrine manner, are involved in the inhibitory tuning of adrenocortical secretion.

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Plasma concentration of urotensin II is raised in hypertension

Abstract: Plasma urotensin II was raised in hypertensive patients compared to normotensive controls, and was directly related to systolic blood pressure. Our findings raise the possibility that urotensin II may have an aetiological role in hypertension and its complications.

Cited by 146 publications

References 15 publications

Is plasma urotensin II concentration an indicator of myocardial damage in patients with acute coronary syndrome?

Is plasma urotensin II concentration an indicator of myocardial damage in patients with acute coronary syndrome?

The Importence of Urotensin and Urotensin Receptors in Cardiovascular System

Urotensin-II and UII-receptor expression and function in the rat adrenal cortex

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