Plasma Concentration of Endothelin and Arterial Pressure in Patients with ADPKD

Giusti, Riccardo; Neri, Maria Giovanna; Angelini, Daniela F.; Carlini, Antonio; Fiorini, I; Bigongiari, P.; Antonelli, Alessandro

doi:10.1159/000424407

Cited by 27 publications

(15 citation statements)

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“…Endothelin 1 is also found in the cyst fluid 32. Patients with ADPKD have higher plasma levels of endothelin 1 than do healthy controls and patients with essential hypertension 33. Moreover, endothelium-dependent relaxation is impaired and endothelial nitric oxide synthase activity is decreased in patients with ADPKD 34,35.…”

Section: Hypertensionmentioning

confidence: 99%

Cardiovascular abnormalities in autosomal-dominant polycystic kidney disease

2009

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Cardiovascular problems are a major cause of morbidity and mortality in patients with autosomal-dominant polycystic kidney disease (ADPKD). Hypertension is a common early symptom of ADPKD, and occurs in approximately 60% of patients before renal function has become impaired. Hypertension is associated with an increased rate of progression to end-stage renal disease and is the most important potentially treatable variable in ADPKD. Left ventricular hypertrophy, which is a powerful, independent risk factor for cardiovascular morbidity and mortality, also occurs frequently in patients with ADPKD. Both hypertension and left ventricular hypertrophy have important roles in cardiovascular complications in these individuals. Moreover, biventricular diastolic dysfunction, endothelial dysfunction, increased carotid intima-media thickness, and impaired coronary flow velocity reserve are present even in young patients with ADPKD who have normal blood pressure and well-preserved renal function. These findings suggest that cardiovascular involvement starts very early in the course of ADPKD. Intracranial and extracranial aneurysms and cardiac valvular defects are other potential cardiovascular problems in patients with ADPKD. Early diagnosis and treatment of hypertension, with drugs that block the renin-angiotensin-aldosterone system, has the potential to decrease the cardiovascular complications and slow the progression of renal disease in ADPKD.

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Section: Hypertensionmentioning

confidence: 99%

Cardiovascular abnormalities in autosomal-dominant polycystic kidney disease

2009

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“…ET-1 is a potent vasoconstrictor which is implicated in the pathophysiology of cyst formation and renal dysfunction in this model [18,50]. Plasma ET-1 levels are high in ADPKD patients [51,52], and ET-1 is present in human cyst fluid [51]. Serum ET-1 levels are higher in men than in women [53], and estrogen therapy [such as hormone replacement therapy (HRT)] reduces ET-1 levels [54].…”

Section: Role Of Et-1mentioning

confidence: 99%

Gender hormones and the progression of experimental polycystic kidney disease

Stringer¹,

Komers²,

Osman³

et al. 2005

Kidney International

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“…Recently, Giusti et al found increased plasma concentrations of endothelin-1 (ET-1) in ADPKD patients compared with healthy subjects and patients with essential hypertension (23). They hypothesized that ET-1 secreted by proliferating tubular cells may contribute to the development of hypertension in ADPKD patients.…”

Section: Fig 1 Correlation Between 24h-map and Ri In All The Adpkd mentioning

confidence: 99%