Plasma Concentration of Amitriptyline and Clinical Response

Pharmacokinetics of methylphenidate in hyperkinetic children.

“…Within the area of psychiatric disturbances, measurement of plasma levels of the tricyclic antidepressants promises to provide more effective clinical management of depression as well as understanding and classification of the heterogenous disorders classified as depression (Braithwaite, Goulding, Theano, Barley & Coppen, 1972;Glassman, Perel, Shostak, Kantor & Fleiss, 1977;Gram, Reisby, Ibsen, Nagy, Dencker, Peterson & Christiansen, 1976;Kragh-Sorenson, Asberg & Eggert-Hansen, 1973).…”

Depression in Patients With Epilepsy

“…-241 -In the present study (see Appendices 15 and 16) there were interpatient variations in steady state antidepressant plasma levels between individuals on the same dose, which can be attributed to genetically determined differences in pharmacokinetics, influence of other drugs especially barbiturates, differences in plasma protein binding, degree of absorption, renal excretion of the TCAs and compliance (Braithwaite et al 1972;Burrows et al 1972).…”

“…Significant negative correlations between nortriptyline levels and response have been found by Coppen et al (1978) and , while significant positive correlations have been reported for amitriptyline plus nortriptyline levels and response by Braithwaite et al (1972), Ziegler et al (1976) and Kupfer et al (1977). Others have described a "therapeutic window" with an optimal therapeutic range for amitriptyline plus nortriptyline Montgomer<J et al 1980b), which is similar to the curvilinear relationship for nortriptyline reported by Asberg et al (1971) and supported by Gruvstad (1973).…”

Plasma Concentrations of Tricyclic Antidepressive Drugs

“…The evidence is quite inconsistent. The closest relationship between plasma concentration and clinical response was claimed by Braithwaite, Goulding, Theana, Bailey & Coppen (1972).…”