Plasma choline depletion is associated with decreased peripheral blood leukocyte acetylcholine in children with cystic fibrosis

Innis, Sheila M.; Davidson, A. G. F.; Bay, Benjamin; Slack, Penelope J.; Hasman, David

doi:10.3945/ajcn.110.005413

Cited by 21 publications

(18 citation statements)

References 36 publications

(49 reference statements)

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“…Our lack of association may also be attributed to the high plasma choline concentration (status) of the children in the Seychelles. A previous study only observed a relationship between plasma choline concentration and leucocyte ACh concentration in children who had low choline status (45) ; no relationship was evident in children who had plasma concentrations of choline, betaine and DMG, similar to those reported in the present analysis. The lack of significant associations may also be owing to the small sample size of the present study.…”

Section: Discussionsupporting

confidence: 90%

Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study

et al. 2013

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Choline is an essential nutrient that is found in many food sources and plays a critical role in the development of the central nervous system. Animal studies have shown that choline status pre- and postnatally can have long-lasting effects on attention and memory; however, effects in human subjects have not been well studied. The aim of the present study was to examine the association between plasma concentrations of free choline and its related metabolites in children and their neurodevelopment in the Seychelles Child Development Nutrition Study, an ongoing longitudinal study assessing the development of children born to mothers with high fish consumption during pregnancy. Plasma concentrations of free choline, betaine, dimethylglycine (DMG), methionine and homocysteine and specific measures of neurodevelopment were measured in 210 children aged 5 years. The children’s plasma free choline concentration (9·17 (sd 2·09) µmol/l) was moderately, but significantly, correlated with betaine (r 0·24; P=0·0006), DMG (r 0·15; P=0·03), methionine (r 0·24; P=0·0005) and homocysteine (r 0·19; P=0·006) concentrations. Adjusted multiple linear regression revealed that betaine concentrations were positively associated with Preschool Language Scale – total language scores (β = 0·066; P=0·04), but no other associations were evident. We found no indication that free choline concentration or its metabolites, within the normal physiological range, are associated with neurodevelopmental outcomes in children at 5 years of age. As there is considerable animal evidence suggesting that choline status during development is associated with cognitive outcome, the issue deserves further study in other cohorts.

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Section: Discussionsupporting

confidence: 90%

Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study

et al. 2013

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“…In addition, Cho is an essential metabolite for the synthesis of acetylcholine in cholinergic neurotransmission. A previous study revealed a positive correlation between plasma Cho concentration and acetylcholine concentration in children with cystic fibrosis, and thus, the level of Cho could be used as an indicator of acetylcholine level in the brain. Acetylcholine is a neurotransmitter associated with attention, learning and memory, and Cho is important in cognitive processes and brain development .…”

Section: Discussionmentioning

confidence: 95%

Metabolic change in the right dorsolateral prefrontal cortex and its correlation with symptom severity in patients with generalized anxiety disorder: Proton magnetic resonance spectroscopy at 3 Tesla

Moon

Kang

Jeong

2015

Psychiatry Clin Neurosci

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Aims: A few neuroimaging studies have demonstrated the key brain areas associated with generalized anxiety disorder (GAD). However, the brain metabolic changes in the dorsolateral prefrontal cortex (DLPFC) of patients with GAD are unclear. This study utilized 3-Tesla proton magnetic resonance spectroscopy ( 1 H-MRS) to assess the DLPFC metabolic change and its correlation with symptom severity in patients with GAD. Methods:Patients with GAD diagnosed using the DSM-IV-TR and age-matched healthy controls participated in this study. Brain metabolite concentrations were measured from a localized voxel on the DLPFC using 3-Tesla 1 H-MRS. Also, the volumetric composition of the gray matter and white matter volumes was assessed using voxel-based morphometry. Results:The choline/creatine and choline/Nacetylaspartate ratios were significantly lower in patients than in controls. However, there were no significant differences in other metabolite ratios between the two groups. Choline concentrations were negatively correlated with anxiety levels as measured by the Hamilton Anxiety Rating Scale and the Generalized Anxiety Disorder Scale 7. There was no significant difference in the gray matter and white matter volumes in the MRS voxel between the two groups. Conclusions:The present study demonstrates that GAD is associated with low a level of choline/Nacetylaspartate in the DLPFC, which is closely related with symptom severity and cognitive dysfunction. This finding will be useful for an understanding of the neural mechanism associated with GAD.

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“…Especially, Cho is an essential metabolite for the synthesis of acetylcholine (ACh) in cholinergic neurotransmission (Zeisel et al, 2006). According to Innis et al (2011), plasma Cho concentration is positively correlated with ACh concentration in children with cystic fibrosis. Thus, Cho indicates the level of Ach, which is a neurotransmitter involved in the functions of attention, learning, and memory.…”

Section: Discussionmentioning

confidence: 99%

Working memory dysfunction associated with brain functional deficits and cellular metabolic changes in patients with generalized anxiety disorder

Moon

Sundaram

Choi

et al. 2016

Psychiatry Research: Neuroimaging

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Plasma choline depletion is associated with decreased peripheral blood leukocyte acetylcholine in children with cystic fibrosis

Cited by 21 publications

References 36 publications

Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study

Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study

Metabolic change in the right dorsolateral prefrontal cortex and its correlation with symptom severity in patients with generalized anxiety disorder: Proton magnetic resonance spectroscopy at 3 Tesla

Working memory dysfunction associated with brain functional deficits and cellular metabolic changes in patients with generalized anxiety disorder

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