Plasma Cholesterol Concentrations in Cockerels and Dogs Treated with Bile Acid Binding Polymer and Cholesterol Synthesis Inhibitors

Tennent, David M.; Kuron, Gunther W.; Zanetti, Mary E.; Ott, Walther H.

doi:10.3181/00379727-108-26895

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1964

2007

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Cited by 12 publications

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“…Because of their anionic properties, bile acids can be bound to ion-exchange resins with an affinity for acidic materials. Tennent, Kuron, Zanetti, and Ott (1961) have shown that the feeding of cholestyramine, a quaternary ammonium anion exchange resin, to monogastric animals results in a decrease of serum cholesterol and serum bile acids. In addition, cholestyramine relieves the pruritis associated with biliary cirrhosis and obstructive jaundice (Van Itallie, Hashim, Crampton, and Tennent 1961).…”

Section: Discussionmentioning

confidence: 99%

The effect of cholestyramine on sporidesmin intoxication in sheep

Peters¹,

Mortimer²

1966

New Zealand Journal of Agricultural Research

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Daily administration (0.8 g per kg of bodyweight) of cholestyramine, a bile acid-binding anion exchange resin, appears to affect the course of the disease produced by dosing sheep with the toxic fungal metabolite, sporidesmin (1 mg per kg bodyweight). Cholestyramine has no detrimental effect on normal sheep.It is suggested that the beneficial effects of cholestyramine on sporidesmin intoxication may be improved by changes in the experimental conditions.

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Section: Discussionmentioning

confidence: 99%