Plasma-chemical modifications of cellulose for biomedical applications

Abstract

A 6-carboxycellulose (in medicine known as "oxidized cellulose" or "oxycellulose") is one of the cellulose derivatives popular in the field of surgery. Health products based on oxidized cellulose are great local hemostatics with unique bactericidal and fully bioabsorbable effects. Traditional process of native cellulose oxidation is described as a complex radical reaction in strong acidic liquid medium doped by toxic nitrous radicals (NO*). Our plasma-chemical reaction demonstrates a new synthesis method of oxidized cellulose with unique bactericidal effect. This plasma-chemical treatment is based on atmospheric plasma discharge in liquid medium leading to the oxidation of polysaccharide molecules resulting in oxycellulose. Final oxycellulose properties were evaluated by infrared spectroscopy and carboxyl content determination. The biological impact showed a strong germicidal effect.

Chitin and Cellulose Processing in Low-Temperature Electron Beam Plasma

“…The advantages of EBP-treatment with respect to gas discharge plasmas have been discussed in our previous papers [ 17 , 18 , 19 ]. Furthermore, the effective controllable destruction of polysaccharides occurs due to the EBP-hydrolysis, whereas the treatment in gas discharge plasmas mostly results in biomaterial oxidation and an improvement of its hydrophilic properties [ 42 , 43 , 44 ].…”

Cellulose defibrillation and functionalization by plasma in liquid treatment

“…Therefore, new properties may be generated by SLP to the liquid dispersions of cellulose. Although promising, the SLP technique was mostly applied to carbonaceous dispersions 19 , 20 and only few works reported on its application to cellulose 21 , 22 .…”

Design and evaluation of plasma polymer deposition on hollow objects by electrical plasma generated from the liquid surface

“…The treatment can result in physical or chemical modifications of the first few molecular layers of the surface. Activation, cleaning, etching, hydroxylation, or oxidation processes were studied to achieve newly prepared functional layers, synthesis of nanoparticles or grafting of polymeric layers on the samples surface . The application of plasma‐chemically enhanced wet methods can lead to significant reduction of environmental problems which are normally associated with industrial techniques resulting from the usage of toxic and corrosive chemicals .…”

“…Activation, cleaning, etching, hydroxylation, or oxidation processes were studied to achieve newly prepared functional layers, synthesis of nanoparticles or grafting of polymeric layers on the samples surface. [1][2][3] The application of plasma-chemically enhanced wet methods can lead to significant reduction of environmental problems which are normally associated with industrial techniques resulting from the usage of toxic and corrosive chemicals. [4] Today, one of the technical challenges is the effective surface plasma treatment of long hollow objects (e.g., tubes) and hollow bodies with irregular surface geometry (flasks, containers, vessels).…”