Plasma Cell Vulvitis: A Rare Cause of Intractable Vulvar Pruritis

Goldstein, Andrew T.; Christopher, Kurt; Burrows, Lara J.

doi:10.1001/archderm.141.6.789

Cited by 29 publications

(38 citation statements)

References 5 publications

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“…Within one week there had been partial resolution but the labia minora, especially the lateral aspect, remained inflamed. Vulval biopsies showed mild epithelial spongiosis and a sub-epithelial infiltrate of plasma cells (4). Stains for pathogens including treponema were negative.…”

Section: Casementioning

confidence: 99%

“…Several triggers have been hypothesized, including friction, warmth, poor hygiene and herpes simplex infection (2,(4)(5)(6). Differential diagnoses include eczema, lichen planus, immunobullous disease, fixed drug eruption, Paget's disease, squamous cell carcinoma, herpes simplex virus infection and candidiasis (4).…”

Section: @ C I C E D I Z I O N I I N T E R N a Z I O N A L Imentioning

confidence: 99%

“…It provides a diagnostic and therapeutic challenge, with large numbers of women receiving a delayed diagnosis and inappropriate treatments (3). The condition presents with pruritus, pain, dyspareunia and burning in the vulval area (3)(4)(5). Examination may reveal erythematous patches, erosive lesions, pinpoint petechial and purpuric spots (4,5).…”

Section: Introductionmentioning

confidence: 99%

“…The condition presents with pruritus, pain, dyspareunia and burning in the vulval area (3)(4)(5). Examination may reveal erythematous patches, erosive lesions, pinpoint petechial and purpuric spots (4,5). Histological features of the condition include the predominant feature of subepidermal plasma cell infiltrates in a band-like pattern, epidermal thinning which is thought to be a result of reduced size and quantity of keratinocytes and reduced size of the horny and granular cell layers.…”

Section: Introductionmentioning

confidence: 99%

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Plasma cell vulvitis: a review of two cases

Strathie-page

Tait

McCloskey

et al. 2016

cderm

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SummaryZoon first described plasma cell balanitis in 1950 and since then there have been many cases described. The equivalent condition in women is plasma cell vulvitis (PCV), which is less frequently reported in the literature. For this reason it continues to be a diagnosis that is challenging to make and leads to difficulties for clinicians and patient alike. We report here the treatment of two cases of plasma cell vulvitis at Royal Perth Hospital and explore the other treatment modalities reported for this condition. Standard therapy for plasma cell vulvitis, which mainly includes topical corticosteroids, was not completely successful in either patient. The first patient had a symptomatic recurrence and the second patient was successfully treated with tacrolimus 0.1%. PCV should be considered in patients presenting with a violaceous vulvitis who fail initial topical steroid, have non-specific initial biopsy results or continue to have pruritus, pain or burning. It is a complicated condition and further research is warranted to further define this clinical entity.KEY WORDS: plasma cell vulvitis.

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Section: Casementioning

confidence: 99%

Section: @ C I C E D I Z I O N I I N T E R N a Z I O N A L Imentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Plasma cell vulvitis: a review of two cases

Strathie-page

Tait

McCloskey

et al. 2016

cderm

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“…One patient with vulvar pruritus resistant to treatment with numerous agents including antifungals, clobetasol, estradiol, and intralesional triamcinolone was found to have PCV on biopsy [19]. She received intralesional injections of interferon alpha-2b (Intron A) without improvement.…”

Section: Case Reportmentioning

confidence: 99%

Plasma Cell Vulvitis: A Case Report and Review of Literature

A¹

2015

J Women’s Health Care

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Plasma cell vulvitis (PCV) is a rare disease affecting anogenital skin. It is also known by multiple names including Zoon's vulvitis and vulvitis circumscripta plasmacellularis. It is an inflammatory condition that can cause severe local discomfort and psychosocial distress. The diagnosis is challenging and often remains unrecognized. It usually presents as a glistening, red, well-demarcated plaque or patch. The pathophysiology is unknown. Treatment recommendation is mostly based on case reports and case series and this condition is often recalcitrant to topical and systemic treatment.

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