Plasma cell-rich lesions in the oral cavity: an overview and case presentation

Abstract

The oral mucosa and gnathic bones can be targets of different types of diseases, however, some of them have plasma cell infiltrate as the main histopathological feature including reactive lesions, oral infectious disease, or a true neoplasm. It is important to examine the clonality of these conditions to demonstrate a polyclonal or monoclonal proliferation, being the last a finding that is more consistent with a neoplastic process. Here, we present four cases reports of oral plasma cell lesions, including Plasma cell mucositis (reactional inflammatory origin), Syphilis (infectious lesion) and two cases of Solitary Plasmacytoma/Multiple Myeloma (neoplastic lesion). Results from the microscopic characteristics associated with immunohistochemical analyses supported the final diagnosis each of them. The patients with Plasm cell mucositis and Syphilis were treated sucessfully. The two female patients with Plasmocytoma extramedullary were referred for chemotherapy treatment.