Plasma cell‐rich acute rejections in living‐related kidney transplantation: a clinicopathological study of 50 cases

Abstract

Our results show that PCAR occurs late after transplant and in many cases is associated with DSAs. Graft outcome was poor when PCAR was associated with DSAs.

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“…[11][12][13][14][15][16][17][18] However, we have previously published our experience of this cohort of 50 patients who were treated aggressively, and we observed a favorable short-term outcome. 21 The follow-up period was brief in that study. It will be important to continue observations on this cohort to see the longterm outcome.…”

“…21,22 It has not yet been formally included in the Banff classification. 22 Recently, some groups have investigated the humoral component of defection in this entity.…”

“…With aggressive therapy, shortterm results showed a favorable response. 21 In this study, we aimed to characterize in detail various histopathologic features of PCAR and to correlate these with other prognostically relevant morphologic, clinical, and outcome variables.…”

Histopathological findings in transplanted kidneys

“…Abbas et al reported that PCAR occurs late after transplantation and in many cases associated with DSAs. Graft outcome was poor when PCAR was associated with DSAs [107]. Due to the rarity of PCAR, its incorporation into the Banff classification is still awaited.…”

“…CNI nephrotoxicity also affects recipients with non-renal organ transplantation. Indeed, the risk of chronic renal failure at 10 years after transplantation of a non-renal organ was reported to be~20% [107]. However, end-stage renal failure caused by CNIs is uncommon, at 3.2-4.8% [109,110].…”