Plasma Cell Mucositis

Shanahan, D.; Shipley, D.; Staines, Konrad

doi:10.1177/0145561319849001

Cited by 7 publications

(12 citation statements)

References 4 publications

(6 reference statements)

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“…Several times, PCM lesions can enter into differential diagnosis with squamous cell carcinoma (SCC) [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]; in literature, there are cases in which a differential diagnosis was made with oral carcinoma and there is a case report where a SCC arose from a mucosal plasmacytosis [13]. Therefore, a correct diagnosis and adequate management of the disease are essential.…”

Section: Case Reports In Dentistrymentioning

confidence: 99%

An Uncommon Case of Plasma Cell Mucositis of the Tongue in a Young Man

Antonelli

Averta

Diodati

et al. 2020

Case Reports in Dentistry

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Plasma cell mucositis (PCM) is an unusual plasma cell proliferative disorder of the upper aerodigestive tract. It is a rare disease, and its etiology is not yet known with variable clinical features. Symptoms include dysphagia, oral pain, and swelling. We described a case of PCM involving the tongue of a 14-year-old man. In the first place, several diagnostic hypotheses were proposed, most of them discarded for incompatibility with blood and laboratory tests. This disease rarely manifests itself on the tongue, especially in young patients with no comorbidities. The management of PCM is mainly aimed at reducing the symptoms, and in our report, the treatment involved the use of systemic prednisone with an improvement of the quality of life. At 1-year follow-up, there was no recurrence of the disease. Many therapeutic treatments are able to stabilize but not able to induce a complete remission. PCM is considered an uncommon benign disorder with a favorable prognosis and should be considered in the differential diagnosis with other inflammatory or neoplastic conditions.

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Section: Case Reports In Dentistrymentioning

confidence: 99%

An Uncommon Case of Plasma Cell Mucositis of the Tongue in a Young Man

Antonelli

Averta

Diodati

et al. 2020

Case Reports in Dentistry

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“…Frequently, patients affected by o-PMC have a previous history of autoimmune or immunologically mediated diseases, such as Sjögren syndrome, autoimmune hepatitis, polymyositis, and diabetes mellitus. Nevertheless, these conditions are not present in all cases, and no single disease has been reported to be consistently associated [ 3 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Clinical phenotypes of o-PCM are heterogeneous, but, characteristically, patients show florid erythematous oral mucosa with cobblestone, nodular, papillomatous, granular, or velvety surface changes [ 6 ]. They can be asymptomatic or, more usually, present oral pain/burning sensation, gingivitis, sore throat, dry cough, and persistent hoarseness [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…The principal histological feature of o-PCM is a dense polyclonal plasmacytic infiltrate in the superficial lamina propria [ 6 ]. Immunohistochemical demonstration of polyclonality with no kappa or lambda light chain restriction allows the differentiation of o-PCM from myeloma, lymphoma, and extramedullary plasmacytoma [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Many treatments have been described, including topical, systemic, and intralesional corticosteroids [ 5 ]. Although steroid therapy is considered beneficial, resulting in disease stabilization and/or complete regression, adverse side effects prevent a prolonged use [ 6 ]. Antibiotics and antifungals have also been utilized [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Pitfalls and Challenges in Oral Plasma Cell Mucositis: A Systematic Review

Coppola

Cantile

Canfora

et al. 2022

JCM

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Plasma cell mucositis (PCM) is an unusual idiopathic disorder characterized by dense infiltrates of plasma cells in submucosa. Clinical phenotypes of oral plasma cell mucositis (o-PMC) are heterogenous. A systematic review has been conducted, aiming to synthesize the available evidence on o-PCM. Literature search, study design, and data analysis were performed following PRISMA guidelines. The SPIDER and the PICO tools were used to structure the research question. In all, 79 case reports and 19 case series on a total of 158 patients (85 females and 73 males; average age: 44.1 years) were identified. Among oral sites involved, gingiva (65.82%) was the most frequent site. The main clinical phenotype was erythema (99.37%). In relation to symptoms, pain (60.76%) was the most reported. On histological examination, all samples showed a dense inflammatory infiltration with predominant plasma cells. The treatment regimens of o-PCM were summarized in six groups: irritant removal; topical/systemic corticosteroids; topical/systemic immunosuppressants/immunomodulators; surgery and similar treatments; radiotherapy and chemotherapy; other therapies, such as antifungals, antibiotics, and antivirals drugs. This is the first systematic review aimed to synthesize the findings of studies on o-PCM. The lack of universally shared information on etiological factors and the absence of international consensus of pharmacological protocols make o-PCM a diagnostic and therapeutic challenge.

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