Plasma cell infiltration of the small bowel: lack of evidence for a non-secretory form of alpha-heavy chain disease.

Gilinsky, Norman H.; Mee, A S; Beatty, David M.; Novis, B. H.; Young, Gloria; Price, S. K.; Purves, Langley R.; Marks, I. N.

doi:10.1136/gut.26.9.928

Cited by 19 publications

(7 citation statements)

References 23 publications

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“…(Patients with this disease are not common, and are restricted mostly to the Middle East and Mediterranean area; in Japan, only 3 cases with this disorder have been reported.) Besides such an extreme condition, either moderate or heavy infiltration of plasma cells has been observed in patients with duodenitis and duodenal ulceration (moderate infiltration) (Beck et al, 1965;Jenkins et al, 1985;, as well as in those with benign immunoproliferative small intestinal disease (moderate or heavy infiltration) (Gilinsky et al, 1985). The IPC hyperplasia observed in the present study is, nevertheless, characterized by its occurrence without any intestinal disease of the types mentioned above.…”

Section: Discussioncontrasting

confidence: 38%

Effects of Refeeding Subsequent to Starvation on the Plasma Cell Population in the Villous Lamina Propria of the Rat Small Intestine

Osogoe

Fujikura

Fukumoto

1991

Okajimas Folia Anatomica Japonica

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Summary: The effects of refeeding subsequent to starvation on the plasma cell population in the lamina propria of the small intestinal villi were studied in adult rats utilizing the immunohistochemical method to detect IgA, IgM and IgG. Under normal conditions of stimulation, intestinal plasma cells (IPC) occur only as a sparse population. However, the present study demonstrated that extensive hyperplasia of IPC could be induced by refeeding after starvation.Starvation for a period of 4 to 6 days alone produced only a small change in the IPC population. In contrast, refeeding subsequent to starvation (for 4 to 6 days) was accompanied by a large increase in the population of IPC: the proportions of these cells among the lamina propria cells often rose to more than 50% within 3 or 6 days. The large majority of the proliferating IPC were found to express IgA, whereas cells bearing IgM or IgG occurred in extremely small numbers in the lamina propria.The mechanism whereby extensive IPC hyperplasia can occur in response to refeeding after starvation is discussed in relation to the possible promotion of transmission of antigenic macromolecules across the mucosal barrier induced by this procedure. It is also suggested that the origin of the proliferating IPC may be correlated with the B cell precursors in the germinal centers of the Peyer's, patches, which are more resistant to starvation than other lymphoid cells.

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Section: Discussioncontrasting

confidence: 38%

Effects of Refeeding Subsequent to Starvation on the Plasma Cell Population in the Villous Lamina Propria of the Rat Small Intestine

Osogoe

Fujikura

Fukumoto

1991

Okajimas Folia Anatomica Japonica

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“…Diarrhea resolved with a 6‐month gluten‐free diet and antibiotics, but gut plasma cell infiltration and hyper‐IgA persisted. Four similar cases, whose evolution appear benign, have been reported so far(3‐5). We studied the in situ intestinal localization of IgA and interleukin (IL)‐6, and found a dense infiltration with IgA‐producing plasma cells and an elevated number of IL‐6‐expressing cells.…”

mentioning

confidence: 76%

Chronic Diarrhea with Massive Intestinal Plasma Cell Infiltration and High Polyclonal Immunoglobulin A Serum Level

Lacaille,

Emile,

Canioni

et al. 1998

J. pediatr. gastroenterol. nutr.

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“…Reference to this subclassification of IPSID was made by Rambaud and Halphen [8] and Fine and Stone [26]. The term 'benign' has been also used by Gilinsky et al [63] for IPSID cases without lymphoma in whom alpha heavy chains cannot be identified. The B-cell proliferation in our two cases corresponded to a different level of B-cell activation: centrocytes in the first case, mature plasma cells in the second.…”

Section: Discussionmentioning

confidence: 96%

Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania

Economidou¹,

Manousos²,

Triantafillidis³

et al. 2006

European Journal of Gastroenterology & Hepatology

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The patients were categorized in three subgroups of IPSID: alpha-chain disease (n=8), non-alpha chain disease with other monoclonal immunoglobulins (n=3), and polyclonal 'non-malignant' IPSID (n=2). In several patients the disease had unusual features, and this in some cases delayed the diagnosis. In suspected cases it is thus of the utmost importance to proceed to an exploratory laparatomy. Patients with stage C disease had a short survival, whereas two patients with stage A alpha-chain disease responded to treatment with cyclophosphamide, vincristine and prednisolone, and cyclophosphamide, doxorubicine, vincristine and prednisolone, respectively, have a disease-free long survival of 35 and 12 years, and appear to be cured.

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Plasma cell infiltration of the small bowel: lack of evidence for a non-secretory form of alpha-heavy chain disease.

Cited by 19 publications

References 23 publications

Effects of Refeeding Subsequent to Starvation on the Plasma Cell Population in the Villous Lamina Propria of the Rat Small Intestine

Effects of Refeeding Subsequent to Starvation on the Plasma Cell Population in the Villous Lamina Propria of the Rat Small Intestine

Chronic Diarrhea with Massive Intestinal Plasma Cell Infiltration and High Polyclonal Immunoglobulin A Serum Level

Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania

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