Plasma Cell Granuloma of the Thyroid with Hashimoto's Thyroiditis: Report of a Rare Case

Abstract

As only eight cases have been p reviously reported in the literature, plasma cell granuloma of the thyroid gland is a rare entity. This condition can be conf used with a benign or malignant neoplastic thyroid process. In this article, we describe a new case ofplasma cell granuloma of the thyroid gland that occurred in a 46-year-old man who also had Hashim oto 's thyroiditis. This case represents only the second documented instan ce of a plasma cell granuloma of the thyroid occurring in the setting of Hashimoto 's thyroiditis. Moreover, it is only the second case of a plasma cell granuloma that has been reported in a male.

Inflammatory Pseudotumor of the Thyroid Gland Showing Prominent Fibrohistiocytic Proliferation. A Case Report

“…All of these reported cases were benign and did not show recurrences; (3) histologically, except for our case, all 14 previously reported cases were PCG; and (4) immunohistochemical study demonstrated that there were no ALKpositive cells in any of the four cases including our cases examined [14,19]. However, ALK gene rearrangement was detected in neither of the reported cases.…”

“…As previously suggested [14,17], the clinical behavior and ALK negativity of the IPT of thyroid gland indicated that the thyroidal counterpart of IPT is a reactive rather than neoplastic lesion.…”

“…At present, the majority of IPT are recognized as neoplasms with intermediate biologic potential namely "inflammatory myofibroblastic tumor" [4,5] However, the clinicopathological findings of IPT of the thyroid gland appear to be different from IPT at sites other than the thyroid (Table 1) [7][8][9][10][11][12][13][14][15][16][17][18][19]: (1) it frequently affects middle-aged and elderly women; (2) the clinical behavior of thyroid gland IPT differs from that of the extrathyroidal IPT. All of these reported cases were benign and did not show recurrences; (3) histologically, except for our case, all 14 previously reported cases were PCG; and (4) immunohistochemical study demonstrated that there were no ALKpositive cells in any of the four cases including our cases examined [14,19].…”

“…In the thyroid gland, IPT appears to be exceedingly rare. Moreover, histologically, previously reported cases were called "plasma cell granuloma" [6][7][8][9][10][11][12][13][14][15][16][17][18]. We report here a case of IPT showing predominantly fibrohistiocytic proliferation and discuss problems in the differential diagnosis.…”

Incidental MALT Type Lymphoma Exhibiting Prominent Plasma Cell Differentiation Associated with Hashimoto’s Thyroiditis. A Two Case Report

“…PCG is a non-neoplastic proliferation of plasma cells within a fibrous stroma with unknown etiology. PCG of the thyroid gland is very rare [7–9]. However, PCG of the thyroid gland is occasionally associated with HT [7–9].…”