Plasma cell granuloma involving the brain and the lung

Abstract

Histological findings, differential diagnosis and specific treatment are reviewed and discussed. Patients with PCG should be radiologically staged. Long term prognosis of PCG is good in cases surgically resectable. Nevertheless, patients require lifelong follow up.

Imaging Features of Meningeal Inflammatory Myofibroblastic Tumor

“…11 The most common symptoms in our patients with intracranial meningeal IMT were headache and seizure (50%, respectively), followed by blindness (25%). These results are similar to those reported by Greiner et al, 7 for which headache was the most common symptom (52.6%), followed by visual disturbance (36.8%) and seizures (26.3%).…”

“…2,6 Central nervous system IMTs have been known to occur with various synchronous or metachronous lesions in other organs. 6,7 However, recurrence at the nasolacrimal duct in patients with meningeal IMT, as seen in patient 6 in our study, has not, to our knowledge, been reported before.…”

“…26 The benefits of radiation and chemotherapy, which have been suggested as alternatives for cases of recurrence after optimal resection or regrowth after incomplete surgery and for residual tumors not responding to steroid therapy, have been limited. 5,7,26,27 Regarding the dosage and duration of anticoagulation therapy, uncomplicated treatment of venous sinus thrombosis associated with meningeal IMT may also be another issue of concern.…”

“…However, when it does involve these sites, it has been reported to occur most commonly in the meninges out of various sites, including the brain parenchyma, ventricle, hypothalamus, sellar region, choroid plexus, skull base, and spine. [6][7][8][9] Meningeal IMT has been rarely reported using the terms "inflammatory pseudotumor" and "plasma cell granuloma," and the prognosis is still unclear. 6,7,10 The purpose of the present study was to describe the imaging features of patients with meningeal IMT and the results on follow-up studies.…”

Intracranial Plasma Cell Granuloma

“…This disease is also known as inflammatory pseudotumor, xanthogranuloma, fibroxanthoma, or histiocytoma due to the predominance of plasma cells which is common to all these lesions 4,16) . Plasma cell granuloma occurs most frequently in the lungs and upper respiratory tract 2) , and a number of cases have been reported in the other organs, including the gastrointestinal tract, thyroid gland, liver, urogenital tract, lymph nodes, heart and tonsils 6,10,12) . However, cases with central nervous system involvement are very rare 6,10,12) , and limited data are available on treatment strategies.…”