Plasma cell differentiation, antibody quality, and initial germinal center B cell population depend on glucose influx rate
Shawna K. Brookens,
Sung Hoon Cho,
Yeeun Paik
et al.
Abstract:Antibody secretion into sera, selection for higher affinity PCB, and the generation of higher Ab affinities are important elements of immune response optimization, and a core function of germinal center reactions. B cell proliferation requires nutrients to support the anabolism inherent in clonal expansion. Glucose usage by GC B cells has been reported to contribute little to their energy needs, with questions raised as to whether or not glucose uptake or glycolysis increase in GC B cells compared to their nai… Show more
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