Plasma cell cheilitis

Abstract

Plasma cell cheilitis is a rare inflammatory disorder of the lip with a characteristic band-like infiltrate of plasma cells in the upper dermis. Differential diagnosis should consider allergic/irritant contact cheilitis, candidiasis, syphilis, Queyrat's erythroplasia, granulomatous cheilitis, plasmoacanthoma, plasmacytoma, squamous cell carcinoma and exfoliative or factitious cheilitis. We observed plasma cell cheilitis in a 60-year-old Caucasian female who had a partial response to topical steroids and oral griseofulvin.

Intertriginous plasmacytosis with plasmoacanthoma: report of a typical case and review of the literature

“…Many therapeutic modalities including topical, intralesional, and systemic corticosteroids, antibiotics, griseofulvin, etretinate, cyclosporine, excision or destruction of the tissue (cryotherapy, CO 2 laser, and electrocoagulation), and radiation therapy have been applied with inconsistent success 2,6–8 . After excision of perianal plasmoacanthoma, we treated our patient with oral prednisolone successfully, as noted in some previous reports 9,10 …”

Solar cheilosis: An ominous precursor

“…31,32 Cheilitis glandularis is an inflammatory disorder of the lower lip salivary glands that typically occurs in older men. 33,34 Patients with cheilitis glandularis often complain of pain while eating or upon palpation.…”

Plasma-cell cheilitis: successful treatment with intralesional injections of corticosteroids

“… 7 The biopsy specimen showed no keratinocyte atypia, solar elastosis or granulomatous infiltrate, thus a diagnosis of actinic cheilitis or cheilitis granulomatosa was not considered. An extramedullary plasmacytoma was also excluded, based on the polyclonal nature of the infiltrate 8 . Lichen planus shows lichenoid interface dermatitis consisting mainly of lymphocytes rather than plasma cells in the upper dermis.…”

“…An extramedullary plasmacytoma was also excluded, based on the polyclonal nature of the infiltrate. 8 Lichen planus shows lichenoid interface dermatitis consisting mainly of lymphocytes rather than plasma cells in the upper dermis. It is also characterized by saw-tooth rete ridges and the presence of colloidal bodies, which were not seen in this case.…”

“…Most reported cases showed poor or limited responses to topical corticosteroids. 2,6,8 Various other treatments have been recommended, including surgical excision, radiation treatment, electrocauterization, cryotreatment, topical fusidic acid and systemic administration of griseofulvin. 5,6 The degree of acanthosis seems to be an important factor influencing treatment outcomes in those who respond to topical corticosteroids.…”