Plasma Cell Acid Phosphatase as an Adjunct in the Differential Diagnosis of Monoclonal Immunoglobulinemias

Tortarolo, Michele; Coppola, Nicola; Grande, M; Buonanno, G; Dammacco, Franco

doi:10.1159/000207158

Cited by 10 publications

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References 15 publications

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“…A semiquantitative AP-scoring method has been described (Hayhoe & Neuman, 1976;Cassuto et al, 1977) for differentiating between multiple myeloma on the one hand and benign paraproteinaemia and reactive plasmacytosis on the other. However, others could not confirm these results (Johansen & Krogh-Jensen, 1980;Tortarolo et al, 1981;Miliani et al, 1982) and neither did we, initially. However, during the present study it appeared possible to improve these results, provided that Cassuto's method for AP scoring be more detailed with regard to class 3 cells.…”

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confidence: 54%

Plasma cell acid phosphatase score in multiple myeloma and related disorders

1985

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A detailed classification of plasma cells stained for acid phosphatase activity is introduced. With this method, patients with multiple myeloma, non-myeloma gammopathies, reactive plasmacytosis and other diseases in which plasma cells are involved, were investigated. The results show that our method can discriminate between multiple myeloma and reactive plasmacytosis. The overlap between multiple myeloma and other monoclonal gammopathies is much smaller than observed in other studies. Surprisingly low levels of acid phosphatase activity were found in the cells from patients with lymphoplasmacytoid immunocytoma. It is concluded that the acid phosphatase score can be of value for studying disorders in which plasma cells are involved.

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confidence: 54%