Plasma calcitonin levels are not lower than normal in osteoporotic women

Prince, R.L.; Dick, I.; Price, Roger J.

doi:10.1016/0378-5122(89)90224-7

Cited by 4 publications

(8 citation statements)

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“…Moreover, a report of CT gene mutation in a young patient with osteoporosis also supports the idea that CT is important in maintaining bone mass (Alevizaki et al 1989). Although the correlation between CT plasma level and BMD remains unclear (Chesnut et al 1980;Leggate et al 1984;Prince et al 1989), we can speculate that a variation in the CT locus may be correlated to variations in the effect of CT in maintaining calcium homeostasis. For example, the CT secretory reaction to calcium infusion in osteoporotic women was reported to be lower than that in normal women (Taggart et al 1982).…”

Section: Discussionmentioning

confidence: 70%

Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus

et al. 2000

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Calcitonin (CT), a calcium-regulating hormone, lowers the calcium level in serum by inhibiting bone resorption. Because CT may play a role in the pathogenesis of osteoporosis, genetic variations in or adjacent to the CT gene may be associated with variations in bone mineral density (BMD). The present study examined the correlation between a dinucleotide (cytosine-adenine; CA) repeat polymorphism at the CT locus and BMD in 311 Japanese postmenopausal women (mean age, 64.1 years). Seven alleles were present in this population; each allele contained 10, 11, 16, 17, 18, 19, or 20 CA repeats. Thus, we designated the respective genotypes A10, A11, A16, A17, A18, A19, and A20. The A10 and A17 alleles were the predominant alleles in the population studied. Z scores (a parameter representing deviation from the age-specific weight-adjusted average BMD) were compared between individuals that possessed one or two alleles of each genotype and those that did not possess the allele. Subjects who possessed one or two A10 alleles had lower BMD Z scores than those who did not (lumbar 2-4 BMD Z score; Ϫ0.148 Ϯ 1.23 vs 0.182 Ϯ 1.54; P ϭ 0.04). No significant relationships were observed between allelic status and background data or biochemical parameters. The significant association observed between BMD and genetic variations at the CT locus implies that polymorphism at this locus may be a useful marker for the genetic study of osteoporosis.

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Section: Discussionmentioning

confidence: 70%

Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus

et al. 2000

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“…Hyperparathyroidism increases in frequency at and after the menopause [62, 631, and PPMO is more severe in hyperparathyroid than in hypoparathyroid women [64]. In most women with PPMO, however, PTH is the same or lower than in normal postmenopausal women [65-671; CT is not lower [68]. Since serum magnesium is normal [69] In premenopausal women, estrogens suppress the PTH-mediated mobilization of bone minerals.…”

Section: O W E Abrahammentioning

confidence: 99%

The Importance of Magnesium in the Management of Primary Postmenopausal Osteoporosis

Abraham¹

1991

Journal of Nutritional Medicine

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Data are presented which support the theory that most cases of primary postmenopausal osteoporosis (PPMO) are not caused by calcium deficiency. The commonly applied therapy of continuous supplementation solely with large doses of calcium is unlikely, therefore, to be of help. It is furthermore suggested that magnesium deficiency has a significant role in PPMO: magnesium is involved in calcium metabolism and in the synthesis of vitamin D, and in maintaining bone integrity. The results of a clinical evaluation of a dietary programme involving magnesium supplementation are also presented.

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“…Some authors described a progressive decrease of serum calcitonin levels with ageing and reduced response of cal citonin on calcium or pentagastrin injections 44], Other authors found no effect of ageing [42,[45][46][47]. Even Prince et al [48] observed enhanced serum calcito nin concentrations in women with osteoporosis. The de crease of calcitonin secretion with ageing is possibly relat ed to the loss of sex steroids, and also calcitriol.…”

Section: Calcitoninmentioning

confidence: 99%

Calciotropic Hormones and Ageing

Wémeau¹

1995

Horm Res

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Calcium availability is reduced in the elderly because not only of decreased dietary intake of calcium and vitamin D, but also reduced solar exposure and a decrease in the production of provitamin D by the skin. Moreover, calcitriol synthesis and calcitriol activity on calcium absorption by the small intestine are decreased with ageing. The age-related plasma parathormone increase enhances bone remodelling. The decrease of calcitonin secretion in the elderly is possibly related to a loss of sex steroids and calcitriol. 24-hour integrated growth hormone (GH) and insulin-like growth factor I concentrations are also decreased with ageing, but the effectiveness of GH therapy on bone mass in the elderly is still assumed.

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Plasma calcitonin levels are not lower than normal in osteoporotic women

Cited by 4 publications

References 0 publications

Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus

Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus

The Importance of Magnesium in the Management of Primary Postmenopausal Osteoporosis

Calciotropic Hormones and Ageing

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