Plasma brain natriuretic peptide levels in COPD without pulmonary hypertension

Gazzar, Ahmed G. El; Hibah, Nabil A. Abdelghaffar; Gouda, Tahany M.; Mansour, Amira I.; Sabry, Mohamad Y.

doi:10.1016/j.ejcdt.2016.10.007

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…This modification of inflammation may be related to LV preload through systemic vasoconstriction, or alternatively lung hyperinflation or inflammation may be causing the increase in BNP levels via an increase in left ventricular wall stress. 2 In our study, COPD patients had significantly higher BNP level compared to patients without COPD irrespective of whether they were smokers or non-smokers. Further, comparing the patients without COPD, BNP levels were higher in smoker compared to non-smoker.…”

Section: Discussionsupporting

confidence: 43%

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Plasma Brain Natriuretic Peptide Levels in Chronic Obstructive Pulmonary Disease Patients Without Pulmonary Hypertension

Gupta¹,

Vanane²,

Dubey³

et al. 2018

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Section: Discussionsupporting

confidence: 43%

“…6,7 Studies related to BNP levels in Stable COPD patients without PH or COR-P however, are limited. 2,8,9 The aim of the present study was to investigate the use of plasma BNP levels as a prognostic marker in patients with stable COPD during exacerbation and after remission.…”

mentioning

confidence: 99%

Plasma Brain Natriuretic Peptide Levels in Chronic Obstructive Pulmonary Disease Patients Without Pulmonary Hypertension

Gupta¹,

Vanane²,

Dubey³

et al. 2018

jebmh

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Natriuretic peptides in elderly patients with chronic obstructive pulmonary disease

Bodrug

Luca

2022

Egypt J Bronchol

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Background Natriuretic peptides (NPs) are considered a useful tool for diagnosing the cardiac or pulmonary origin of acute dyspnea in the emergency department. The aim of this study was to evaluate NP in elderly patients with chronic obstructive pulmonary disease (COPD). Materials and methods In the PubMed and Hinari databases, we identified 465 comprehensive articles in English, published in the years 1990–2021, which provided information on natriuretic peptides in elderly patients with COPD. The final bibliography contains 49 relevant sources. Results NP, specially BNP/NT-proBNP values are frequently elevated in patients with COPD, reflecting three complex aspects of the interrelated cardio-pulmonary continuum: (1) left ventricular systolic and diastolic dysfunction, (2) pulmonary vascular and right heart remodeling, (3) global cardiovascular risk and comorbidities. The additional increase in BNP/NT-proBNP values during acute exacerbation of COPD is probably a marker for both, acute estate of COPD and varying degrees of underlying cardiopulmonary disease. The results of the studies suggest the role of natriuretic peptides as relevant prognostic biomarkers not only for patients with cardiovascular disease, but also for patients with chronic obstructive pulmonary disease, which has an important clinical implication. The determination of these biomarkers in patients with chronic obstructive pulmonary disease allows stratification for prognosis: it is able to select a subgroup of patients at higher risk, which requires increased attention and optimization of treatment. Conclusion NPs, especially BNP/NT-proBNP are relevant prognostic biomarkers not only for patients with cardiovascular disease, but also for patients with COPD, acute exacerbations and haemodynamic disorders like PH and cor pulmonale. Estimating BNP/NT-proBNP in COPD patients has an important clinical implication: it allows the selection of a subgroup of patients at higher risk, which requires increased attention and treatment optimization.

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Plasma brain natriuretic peptide levels in COPD without pulmonary hypertension

Cited by 2 publications

References 15 publications

Plasma Brain Natriuretic Peptide Levels in Chronic Obstructive Pulmonary Disease Patients Without Pulmonary Hypertension

Plasma Brain Natriuretic Peptide Levels in Chronic Obstructive Pulmonary Disease Patients Without Pulmonary Hypertension

Natriuretic peptides in elderly patients with chronic obstructive pulmonary disease

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