Plasma brain natriuretic peptide levels in chronic hemodialysis patients: Influence of coronary artery disease

Nishikimi, Toshio; Futoo, Yasuo; Tamano, Koich; Takahashi, Masaki; Suzuki, Tsuneo; Minami, Junich; Honda, Takeshi; Uetake, Shuichiro; Asakawa, Hiroshi; Kobayashi, Naohiko; Horinaka, Shigeo; Ishimitsu, Toshihiko; Matsuoka, Hiroaki

doi:10.1053/ajkd.2001.24523

Cited by 103 publications

(78 citation statements)

References 20 publications

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“…These results agreed with Naganuma et al who reported that high plasma BNP concentrations in HD patients were associated with volume overload [3]. Also Nishikimi et al concluded that plasma BNP levels were closely associated with the amount of extracellular water and the overhydration status in hemodialysis patients [14]. On the other hand, Osajima et al found no significant correlation between changes in plasma BNP concentration and reductions in body weight during HD [15].…”

Section: Discussionsupporting

confidence: 86%

A Cut off Value for Brain Natriuretic Peptide Indicating Volume Overload in Hemodialysis Patients

Baki¹,

Mohab²,

Reda³

et al. 2017

J Kidney

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Section: Discussionsupporting

confidence: 86%

A Cut off Value for Brain Natriuretic Peptide Indicating Volume Overload in Hemodialysis Patients

Baki¹,

Mohab²,

Reda³

et al. 2017

J Kidney

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“…BNP predicted mortality in dialysis patients without heart failure, and the prognostic value of BNP was independent of LVMI and LVEF (27). Furthermore, changes in BNP levels with hemodialysis correlated with extracellular fluid retention and volume change independent of LV function (43)(44)(45)(46). However, there are as yet no data on this aspect in PD patients.…”

Section: Discussionmentioning

confidence: 99%

N-Terminal Pro-Brain Natriuretic Peptide

Wang

Lam²,

Yu³

et al. 2007

Journal of the American Society of Nephrology

141

134

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This study was performed to determine whether the N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is a useful biomarker in predicting cardiovascular congestion, mortality, and cardiovascular death and event in chronic peritoneal dialysis (PD) patients. A prospective cohort study was conducted in 230 chronic PD patients in a dialysis unit of a university teaching hospital. Serum NT-pro-BNP was measured at baseline together with echocardiography and dialysis indices. Each patient was followed for 3 yr from the day of enrollment or until death. Time to develop first episode of cardiovascular congestion and other cardiovascular event and time to mortality and cardiovascular death were studied in relation to NT-pro-BNP. NT-pro-BNP showed the strongest correlation with residual GFR, followed by left ventricular ejection fraction and left ventricular mass index. In the univariate Cox regression model, NT-pro-BNP was a significant predictor of cardiovascular congestion, mortality, and cardiovascular death and event. In the fully adjusted multivariable Cox regression analysis that included residual GFR, left ventricular ejection fraction, and left ventricular mass index, the hazard ratios for cardiovascular congestion, mortality, composite end point of mortality and cardiovascular congestion, and cardiovascular death and event for patients of the fourth quartile were 4.25 (95% confidence interval [CI] 1.56 to 11.62; P ‫؍‬ 0.005), 4.97 (95% CI 1.35 to 18.28; P ‫؍‬ 0.016), 5.03 (95% CI 2.07 to 12.26; P < 0.001), 7.50 (95% CI 1.36 to 41.39; P ‫؍‬ 0.021), and 9.10 (95% CI 2.46 to 33.67; P ‫؍‬ 0.001), respectively, compared with the first quartile. These data showed that NT-pro-BNP is an important risk predictor of cardiovascular congestion, mortality, and adverse cardiovascular outcomes in chronic PD patients and adds important prognostic information beyond that contributed by left ventricular hypertrophy, systolic dysfunction, and other conventional risk factors.

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“…27,28 Likewise, higher BNP and NTpro-BNP levels were observed in both HD and PD patients with underlying coronary artery disease. 35,41 A major factor that confounds the interpretation of elevated BNP and NTpro-BNP and limits the current utility of BNP and NT-pro-BNP in the ESRD population is renal dysfunction. Both BNP and NT-pro-BNP increased with deteriorating renal function.…”

Section: Bnp or Nt-pro-bnp As A Marker Of Increased LV Wall Stressmentioning

confidence: 99%

Use of Cardiac Biomarkers in End-Stage Renal Disease

Wang¹,

Lai²

2008

Journal of the American Society of Nephrology

177

139

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Plasma brain natriuretic peptide levels in chronic hemodialysis patients: Influence of coronary artery disease

Cited by 103 publications

References 20 publications

A Cut off Value for Brain Natriuretic Peptide Indicating Volume Overload in Hemodialysis Patients

A Cut off Value for Brain Natriuretic Peptide Indicating Volume Overload in Hemodialysis Patients

N-Terminal Pro-Brain Natriuretic Peptide

Use of Cardiac Biomarkers in End-Stage Renal Disease

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