Plasma Biomarkers of Evolving Encephalopathy and Brain Injury in Neonates with Hypoxic-Ischemic Encephalopathy

Li, Ruoying; Lee, Jennifer K.; Govindan, Rathinaswamy B.; Graham, Ernest M.; Perin, Jamie; Vézina, Gilbert; Tekes, Aylin; Chen, May; Northington, Frances J.; Parkinson, Charlamaine; O'Kane, A; McGowan, Meaghan; Krein, Colleen; Al-Shargabi, Tareq; Chang, Taeun; Massaro, An N.

doi:10.1016/j.jpeds.2022.07.046

Cited by 8 publications

(5 citation statements)

References 63 publications

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“…Our observations are consistent with other studies that showed an increase in tau protein levels 3-7 days post-asphyxia [14,16]. In addition, MRI studies have shown that elevated levels of tau protein on days 2-3 after hypothermia treatment are associated with death or severe neuronal damage [19]. Additionally, the level of total tau protein, which was tested by hippocampal microdialysis, was increased in experimental hypoxic-ischemic encephalopathy after hypothermic cardiac arrest [18].…”

Section: Discussionsupporting

confidence: 92%

“…An elevated level of tau protein in the blood indicates the development of a serious pathology of the central nervous system, in particular massive pathological changes in neuronal cells, including their progressive death [16,19]. Our observations are consistent with other studies that showed an increase in tau protein levels 3-7 days post-asphyxia [14,16].…”

Section: Discussionsupporting

confidence: 91%

“…Additionally, the level of total tau protein, which was tested by hippocampal microdialysis, was increased in experimental hypoxic-ischemic encephalopathy after hypothermic cardiac arrest [18]. Elevated blood tau protein levels have also been associated with impaired postasphyxia brain autoregulation [19]. The results of yet another study showed an indisputable negative correlation between the level of tau protein in the blood and the developmental rate of newborns after perinatal asphyxia [20].…”

Section: Discussionmentioning

confidence: 99%

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Preservation of Biomarkers Associated with Alzheimer’s Disease (Amyloid Peptides 1-38, 1-40, 1-42, Tau Protein, Beclin 1) in the Blood of Neonates after Perinatal Asphyxia

Tarkowska,

Furmaga-Jabłońska,

Bogucki

et al. 2023

IJMS

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Perinatal asphyxia is a complex disease involving massive death of brain cells in full-term newborns. The most impressive consequence of perinatal asphyxia is a neurodegenerative brain injury called hypoxic–ischemic encephalopathy. Management of newborns after perinatal asphyxia is very difficult due to the lack of measurable biomarkers that would be able to assess the severity of the brain injury in the future, help in the selection of therapy, assess the results of treatment and determine the prognosis for the future. Thus, these limitations make long-term neurodevelopmental outcomes unpredictable during life. Quantifying biomarkers that can detect subclinical changes at a stage where routine brain monitoring or imaging is still mute would be a major advance in the care of neonates with brain neurodegeneration after asphyxia. Understanding the effect of perinatal asphyxia on changes in blood neurodegenerative biomarkers over time, which would be commonly used to assess the severity of postpartum encephalopathy, would be an important step in developing precision in predicting the consequences of brain injuries. We urgently need more accurate early predictive markers to guide clinicians when to use neuroprotective therapy. The needed neurodegenerative biomarkers may represent neuronal pathological changes that can be recognized by new technologies such as genomic and proteomic. Nevertheless, the simultaneous blood tau protein and various amyloid changes with the addition of an autophagy marker beclin 1 after perinatal asphyxia have not been studied. We decided to evaluate serum biomarkers of neuronal injury characteristic for Alzheimer’s disease such as amyloid peptides (1-38, 1-40 and 1-42), tau protein and beclin 1, which can predict the progression of brain neurodegeneration in future. In this paper, we report for the first time the significant changes in the above molecules in the blood after asphyxia compared to healthy controls during the 1–7, 8–14 and 15+ days ELISA test.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Preservation of Biomarkers Associated with Alzheimer’s Disease (Amyloid Peptides 1-38, 1-40, 1-42, Tau Protein, Beclin 1) in the Blood of Neonates after Perinatal Asphyxia

Tarkowska,

Furmaga-Jabłońska,

Bogucki

et al. 2023

IJMS

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show abstract

“… 24 In newborns with hypoxic-ischemic encephalopathy, elevated tau levels were associated with death or severe brain injury on MRI, and higher baseline tau levels were associated with worse 1-year outcomes. 25 , 26 In a multicenter study of biomarker concentrations following pediatric in-hospital or out-of-hospital cardiac arrest, tau levels measured 1–3 days post-arrest were associated with death or poor neurobehavioral outcome at one year in multivariable analyses. 20 …”

Section: Discussionmentioning

confidence: 99%

Higher levels of brain injury biomarker tau are associated with unfavorable outcomes in patients supported with ECMO following cardiac arrest

Schwartz,

Ng,

Roem

et al. 2024

Resuscitation Plus

Self Cite

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“…It has been widely used for the prediction of possible neurological dysfunction, surgery monitoring and pain assessment in newborn infants. [15][16][17][18][19][20] NIRS is used to monitor the oxygen saturation of local tissue by using the different absorption rates of oxygen, haemoglobin and deoxyhaemoglobin. The oxygen consumption of local tissue can be calculated in combination with the whole-body oxygen saturation in the same period.…”

Section: Open Accessmentioning

confidence: 99%

Cerebral near-infrared spectroscopy monitoring to predict periventricular-intraventricular haemorrhage and neurodevelopmental outcomes in preterm infants: a protocol for a systematic review and meta-analysis

Zhang,

Liu,

Mao

et al. 2023

bmjpo

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IntroductionPeriventricular-intraventricular haemorrhage (PV-IVH) is one of the major cause of mortality and long-term neurodevelopmental sequela in preterm infants born at less than 32 weeks of gestation. Near-infrared spectroscopy (NIRS) monitoring can detect brain tissue oxygen saturation changes before the occurrence of PV-IVH in the early postnatal period. However, the time window for NIRS monitoring, the absolute value or change value of brain tissue oxygen saturation, and the accuracy of NIRS in predicting PV-IVH and its neurodevelopmental outcomes has not been systematically reviewed. In this review, we will investigate the diagnostic accuracy (sensitivity, specificity and accuracy) of NIRS in predicting PV-IVH, its severity and outcomes.Methods and analysisLiterature will be searched in the PubMed, EMBASE, Web of Science and Cochrane Library databases without limitation of region or time of publication. All published literature without language restrictions, including randomised/quasicontrolled trials and observational studies, will be considered. Studies providing index test values (the absolute value or change value of oxygen saturation using NIRS) will be included. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses of Diagnostic Test Accuracy Studies (DTA) process will be followed for writing. The risk of bias will be assessed according to the Quality Assessment of Diagnostic Accuracy Studies-2 tool. The outcomes will be the diagnostic accuracy (sensitivity, specificity and accuracy) of NIRS in predicting PV-IVH, long-term neurodevelopmental outcomes and infant mortality. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool will be used to evaluate the quality of the evidence.Ethics and disseminationIn this systematic review, data will be collected from published articles for collation and analysis, without a separate ethical review.PROSPERO registration numberCRD42022316080.

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Plasma Biomarkers of Evolving Encephalopathy and Brain Injury in Neonates with Hypoxic-Ischemic Encephalopathy

Cited by 8 publications

References 63 publications

Preservation of Biomarkers Associated with Alzheimer’s Disease (Amyloid Peptides 1-38, 1-40, 1-42, Tau Protein, Beclin 1) in the Blood of Neonates after Perinatal Asphyxia

Preservation of Biomarkers Associated with Alzheimer’s Disease (Amyloid Peptides 1-38, 1-40, 1-42, Tau Protein, Beclin 1) in the Blood of Neonates after Perinatal Asphyxia

Higher levels of brain injury biomarker tau are associated with unfavorable outcomes in patients supported with ECMO following cardiac arrest

Cerebral near-infrared spectroscopy monitoring to predict periventricular-intraventricular haemorrhage and neurodevelopmental outcomes in preterm infants: a protocol for a systematic review and meta-analysis

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