Plasma biomarkers for the identification of women at risk for early-onset preeclampsia

Kοlialexi, Aggeliki; Tsangaris, George Th.; Sifakis, Stavros; Gourgiotis, D; Katsafadou, Angeliki I.; Lykoudi, Alexandra; Marmarinos, Antonios; Mavreli, Danai; Pergialiotis, Vasilios; Fexi, Dimitra; Mavrou, Ariadni; Papaioanou, G; Παπαντωνίου, Ν.

doi:10.1080/14789450.2017.1291345

Cited by 30 publications

(26 citation statements)

References 29 publications

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“…Kolialexi et al demonstrated a 3-fold increase in plasma concentrations of AAT in prospectively analyzed samples from 10 women with subsequent EOPE, compared with those of 40 controls with normal pregnancies, matched for gestational age and duration of sample storage. 22 This is in line with other reports of significantly increased AAT levels in patients with clinical symptoms of severe PE vs those with uncomplicated pregnancies. 19,29,30 Obviously, this might simply result from inflammatory components of pregnancies complicated by EOPE, but AAT should also be considered a candidate biomarker or part of a biomarker panel in early screening for EOPE.…”

Section: Preeclampsiasupporting

confidence: 92%

“…14 Furthermore, AAT may play a role in fertility regulation, pregnancy loss and other obstetric pathologies. [15][16][17][18][19][20][21][22] Finally, there is data from maternal serum protein profiling showing that alpha-1-antitrypsin is among the markers for non-invasive prenatal diagnoses of trisomy 21, 18 and 13. 23…”

Section: The Alpha-1 Antitrypsin Protein and Human Reproductionmentioning

confidence: 99%

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Beyond thelungs: Alpha-1 antitrypsin’s potential role in human gestation

Jezela‐Stanek¹,

Chorostowska‐Wynimko²

2019

Adv Clin Exp Med

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This study was performed as part of the scientific project-Dissemination and optimization of alpha-1 antitrypsin deficiency diagnostic algorithm in patients with chronic lung diseases (theme 5/4), National Institute of Tuberculosis and Lung Diseases, Warszawa, Poland. The authors are beholden to the Polish Foundation for Patients with Alpha-1 Antitrypsin Deficiency for their financial support of this research.

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Section: Preeclampsiasupporting

confidence: 92%

Section: The Alpha-1 Antitrypsin Protein and Human Reproductionmentioning

confidence: 99%

Beyond thelungs: Alpha-1 antitrypsin’s potential role in human gestation

Jezela‐Stanek¹,

Chorostowska‐Wynimko²

2019

Adv Clin Exp Med

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“…Wen Q et al screened a 19-peptide panel including AAT to discriminate preeclampsia from confounding chronic hypertension with high specificity and sensitivity [ 14 ]. Recently, proteomic profiling also revealed AAT as preeclampsia-related serum proteins in pregnant women [ 15 , 16 ]. In addition to serum, urine AAT may potentially serve as early indicators of preeclampsia [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Alpha-1-antitrypsin functions as a protective factor in preeclampsia through activating Smad2 and inhibitor of DNA binding 4

Feng

Wang

et al. 2017

Oncotarget

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Pre-eclampsia (PE) is one of the most common reason for high morbidity and mortality of maternal and prenatal infants. Production from oxidative stress results in maternal ROS system and anti-oxidation defense system imbalance to promote tissue ischemia and hypoxia, and ultimately impairs the maternal organs and placenta. Our previous study showed that exogenous Alpha-1-antitrypsin (AAT) and overexpression of AAT in umbilical vein cell (HUVEC) hypoxia-reoxygenation model could increase the activity of antioxidant enzymes, and played a protective role in preeclampsia animal model. In this study, we aim to investigate the underlying mechanism by which AAT prevents PE progress. Whole-exome sequencing was performed to screen the genes altered by AAT. We found that AAT knockdown altered the expression of Smad family and Id family genes, and further demonstrated that AAT positively regulated Id4 expression through activating Smad2. Reduced Id4 expression and Smad2 phosphorylation were observed in preeclampsia animal model, which was also confirmed in human placenta tissues. In addition, AAT protected HUVEC cells from hypoxia/reoxygenation injury and relieved preeclampsia symptoms through Smad2/Id4 axis. Our data illustrate AAT/Smad2/Id4 axis is an important mediator of placenta and vascular function during pregnancy. These findings provide insights into events governing pregnancy-associated disorders, such as preeclampsia.

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“…Vitamin D-binding protein has been also implicated recently in the pathogenesis of preeclampsia. A small pilot study showed that VDBP in the first trimester of pregnancy was upregulated in women who developed early-onset preeclampsia (EOPE) compared to controls, suggesting a hypothetical VDBP utility, as a biomarker for the diagnosis of EOPE ( 44 ). These results were in accordance with a previous cohort study, which included 239 pregnant women, 107 with preeclampsia, and 132 controls, where phenotype frequency distribution of serum group-specific component (Gc) and haptoglobin (Hp) was determined ( 45 ).…”

Section: Vdbp As a Marker Of A Healthy Ongoing Pregnancy: Clinical Immentioning

confidence: 99%

Deconvoluting the Biological Roles of Vitamin D-Binding Protein During Pregnancy: A Both Clinical and Theoretical Challenge

et al. 2018

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The teleological purpose of an ongoing pregnancy is to fulfill its fundamental role of a successful, uncomplicated delivery, in conjunction with an optimal intrauterine environment for the developing fetus. Vitamin D metabolism is adapted to meet both these demands during pregnancy; first by stimulation of calcium absorption for adequate intrauterine bone mineral accrual of the fetus, and second, by enhancing systemic and local maternal tolerance to paternal and fetal alloantigens. Vitamin D-binding protein (VDBP) is one of the key biomolecules that optimize vitamin D homeostasis and also contributes as an immune regulator for a healthy, ongoing pregnancy. In this regard, recent results indicate that dysregulation of VDBP equilibrium could be a risk factor for adverse fetal, maternal, and neonatal outcomes, including preeclampsia, preterm birth, and gestational diabetes. Moreover, it has been hypothesized to be also implicated in the interpretation of vitamin D status in the pregnant state. The aim of this review is to assess available literature regarding the association of VDBP with clinical outcomes during pregnancy, as a potential biomarker for future clinical practice, with a discourse on current knowledge gaps and future research agenda.

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Plasma biomarkers for the identification of women at risk for early-onset preeclampsia

Abstract: The differentially expressed proteins represent potential biomarkers for the early screening for EOPE. Follow-up experiments however are necessary for evaluation.

Cited by 30 publications

References 29 publications

Beyond thelungs: Alpha-1 antitrypsin’s potential role in human gestation

Beyond thelungs: Alpha-1 antitrypsin’s potential role in human gestation

Alpha-1-antitrypsin functions as a protective factor in preeclampsia through activating Smad2 and inhibitor of DNA binding 4

Deconvoluting the Biological Roles of Vitamin D-Binding Protein During Pregnancy: A Both Clinical and Theoretical Challenge

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