Plasma Betatrophin Levels of Subjects Classified with Normal, Impaired, and Diabetic Glucose Tolerance, and Subjects with Impaired Fasting Glucose

Özyazgan, Sibel; Önal, Burak; Kurtulus, Eda Merve; Uzun, Hafize; Akkan, Gökhan; Konukoğlu, Dildar

doi:10.1055/s-0043-104383

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…Recently, several researchers have raised a concern regarding the potential influence of glycemic status differences on betatrophin levels [36, 37]. Stratified subgroup analyses were conducted to evaluate between-study variations in glycemic status.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Circulating ANGPTL8/Betatrophin Concentrations and Adult Obesity: A Meta-Analysis

Qin

Wang

et al. 2019

Disease Markers

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In this study, we evaluated the relationship between circulating betatrophin levels and obesity. Obesity is a common public health problem that is increasing globally. Betatrophin, a newly identified protein, is predominantly expressed in white and brown fat tissues and in the liver. Growing evidence suggests that betatrophin plays a pivotal role in metabolism, including the synthesis and degradation of lipids in cells, and adipocyte differentiation. Previous studies have assessed the association between circulating betatrophin levels and obesity; however, this relationship remains unclear. Therefore, our study is aimed at examining the impact of betatrophin on obesity using a meta-analysis of the current evidence. We performed a meta-analysis to quantify the relationship between betatrophin levels and obesity. A literature search was conducted through the EMBASE, Web of Science, and MEDLINE databases. Retrieved studies were screened, without any language restrictions to identify relevant literature published up to December 2018. Observational studies, in which the association between circulating concentrations of betatrophin and obesity was evaluated, were considered suitable for the systematic review. Of the 65 manuscripts retrieved, 9 datasets from 6 studies, involving 681 participants, detected an association between circulating betatrophin and obesity. Circulating betatrophin levels of obese subjects were higher than those of nonobese subjects (random − effects weighted mean difference (WMD) = 0.250 μg/mL, 95% CI: 0.048–0.451, I2 = 94.8%, p = 0.015), yet with significant between-study heterogeneity. This heterogeneity appeared to be modified by glycemic status but not by age, the ELISA kits used, sample source, or body mass index. The high circulating betatrophin concentration may directly increase the risk of obesity in adults. Betatrophin may serve as a therapeutic target for obesity in adults.

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Section: Discussionmentioning

confidence: 99%

The Relationship between Circulating ANGPTL8/Betatrophin Concentrations and Adult Obesity: A Meta-Analysis

Qin

Wang

et al. 2019

Disease Markers

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“…IFG was defined as FPG of 110 mg/dL (6.1 mmol/L) to <125 mg/dL (7.0 mmol/L) based on WHO criteria. 20,21 Disease definition. Nonalcoholic fatty liver disease (NAFLD) was diagnosed based on abdominal ultrasonography findings plus the exclusion of alcohol consumption, viral infection, or autoimmune liver disease.…”

Section: Methodsmentioning

confidence: 99%

Relationship Between Serum Gamma-Glutamyl Transferase Level and Impaired Fasting Glucose Among Chinese Community-Dwelling Adults: A Follow-Up Observation of 6 Years

Wang

Zang

et al. 2021

Metabolic Syndrome and Related Disorders

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Objective: We aimed to investigate the relationship between serum gamma-glutamyl transferase (GGT) and fasting blood glucose (FBG) levels, as well as the cumulative risk of impaired fasting glucose (IFG) regulation in the Chinese adult population after 6 years of follow-up. Methods: A total of 1360 apparently healthy Chinese men and women who completed a community-based health examination survey and did not have IFG in central China in 2010 and 2016 were included in this study. The patients were divided into four groups according to their baseline GGT (in quartiles). The relationship between GGT levels and FBG levels was examined using general linear regression models. The effect of the GGT level on the risk of IFG was analyzed using multivariate logistic regression. The first quartile group of GGT levels was set as the dummy variable in the model, and the odds ratios and 95% confidence intervals of the remaining quartile groups relative to the first quartile group were obtained. Results: After 6 years of follow-up, 16.4% (188/1148) of participants were diagnosed with IFG. The cumulative incidence of IFG in the four groups according to their baseline GGT levels (in quartiles) was 7.7%, 16.1%, 15.8%, and 26.8%, respectively. Based on the Cox multiple regression, the hazard ratio for IFG increased by 28.9% for each unit of increase in the baseline GGT level after adjusting for the confounding factors. The GGT levels of participants in the first quartile were used as the reference group. The relative risks of IFG in the second, third, and fourth quartiles of GGT were 1.70, 1.55, and 2.46, respectively (P = 0.005). Conclusions: GGT was positively associated with the risk of IFG and can be used as an indicator to assess whether a patient may develop prediabetes.

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“…The negative association between betatrophin concentrations and BCS in the healthy dogs is different from reported increased betatrophin in obesity in most reports in humans, 12 although decreased concentrations in obesity or no difference between lean to and obese individuals were reported in a few studies in humans, 42,43 and it was suggested that this heterogeneity partially could be explained by glycemic status. 12 In non-obese human subjects, betatrophin concentrations were increased with impaired glucose tolerance, 44 suggesting the increase in betatrophin in obesity might be attributed, at least partially to glucose intolerance. Therefore, the different alteration in betatrophin in obesity in dogs might be attributed to the fact that obese dogs do not become glucose intolerant despite long-standing insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Alterations in serum concentrations of visfatin and betatrophin in dogs with hypothyroidism

Mazaki‐Tovi,

Shachar,

Even Zur

2023

Veterinary Internal Medicne

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BackgroundHypothyroidism in dogs is associated with obesity and altered lipid and carbohydrate metabolism. The adipokines, visfatin, and betatrophin, affect glucose tolerance. Betatrophin is involved in lipid regulation.HypothesisVisfatin and betatrophin serum concentrations are altered in hypothyroid dogs.AnimalsDogs with naturally occurring hypothyroidism (n = 25) and healthy dogs (n = 25).MethodsInsulin, visfatin, and betatrophin serum concentrations were measured in all dogs and 19 of the hypothyroid dogs after 30 days of thyroxine treatment. Body condition score (BCS) was determined (1‐9 scale).ResultsVisfatin concentrations were lower in hypothyroid compared with healthy dogs (mean, 95% confidence interval [CI]; 2.0 ng/mL, 1.2‐3.3 vs 5.1 ng/mL, 3.3‐7.8; P = .004) and increased post‐treatment (3.1 ng/mL, 1.9‐4.9 vs 2.6 ng/mL, 1.6‐4.1; P = .05). Betatrophin concentrations were lower in lean to normal (body condition score [BCS], 3‐5) hypothyroid dogs compared to lean to normal healthy dogs (52 pg/mL, 9‐307 vs 597 pg/mL, 216‐1648; P = .03), but were not different between overweight (BCS, 6‐9) hypothyroid and healthy dogs (341 pg/L, 168‐695 vs 178 pg/mL, 77‐415; P = .26), and decreased post‐treatment in overweight dogs (206 pg/mL, 87‐488 vs 268 pg/mL, 112‐640; P = .004). Visfatin concentrations were higher in overweight compared with lean to normal dogs (4.7 ng/mL, 3.3‐6.6 vs 2.2 ng/mL, 1.2‐4.2; P = .04). Betatrophin concentrations were positively correlated with BCS (r = .47, P = .02) and insulin concentrations (r = .48, P = .03) in hypothyroid dogs and negatively correlated with BCS (r = −.47, P = .02) and thyroid stimulating hormone concentrations (r = −.56, P = .01) in healthy dogs.Conclusions and Clinical ImportanceHypothyroidism in dogs is associated with alterations in visfatin and betatrophin concentrations that partially resolve with thyroxine treatment.

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Plasma Betatrophin Levels of Subjects Classified with Normal, Impaired, and Diabetic Glucose Tolerance, and Subjects with Impaired Fasting Glucose

Cited by 5 publications

References 26 publications

The Relationship between Circulating ANGPTL8/Betatrophin Concentrations and Adult Obesity: A Meta-Analysis

The Relationship between Circulating ANGPTL8/Betatrophin Concentrations and Adult Obesity: A Meta-Analysis

Relationship Between Serum Gamma-Glutamyl Transferase Level and Impaired Fasting Glucose Among Chinese Community-Dwelling Adults: A Follow-Up Observation of 6 Years

Alterations in serum concentrations of visfatin and betatrophin in dogs with hypothyroidism

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