Plasma beta-endorphin levels and childhood intussusception

Ros, Simon P.; Reynolds, Sally; Bhisitkul, Donna M.; Ionides, S. P.

doi:10.1016/0736-4679(94)90481-2

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…If so, miosis would be a valuable clue for diagnosing these children. However, other authors failed to show this connection and as pupil size was not recorded in the vast majority of our patients, we cannot confirm this finding either (11).…”

Section: Discussioncontrasting

confidence: 82%

Neurological symptoms in children with intussusception

et al. 2009

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Section: Discussioncontrasting

confidence: 82%

Neurological symptoms in children with intussusception

et al. 2009

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“…There have been theories suggesting possible release of endorphins, and toxic metabolites from the compromised gut mucosa 8. Some clinicians have seen a response after administration of naloxone,5 , 8 although other researchers have found endorphin levels in patients with intussusception to be no different from those of controls 9. Rapidly developing dehydration and shock can contribute towards lethargy in the paediatric population.…”

Section: Discussionmentioning

confidence: 99%

Neurological presentation of intussusception: case discussion and literature review

Venkatesha¹

2009

Case Reports

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A previously well, 7-month-old baby boy presented with a 6 h history of lethargy. On examination, he was drowsy and responsive only to painful stimuli (Glasgow Coma Score 9/15). Vital parameters were normal. Detailed systemic examination was normal. The patient was commenced on antibiotics in view of non-specific findings of lethargy in an infant. A few hours later, the mother reported an episode of uprolling of eyes with jerking of limbs. An array of investigations to rule out meningoencephalitis, toxic ingestion, sepsis, metabolic disease and intracranial pathology were within normal limits. The following day the patient passed stools with a few fresh blood stains. He was noted to have a 2×3 cm mass in the left upper quadrant of the abdomen. Abdominal x ray and ultrasound were undertaken to rule out intussusception, and were reported as normal. However, in view of the high index of suspicion for intussusception, the patient was transferred to a tertiary hospital for further evaluation and management. He continued to be lethargic, and a repeat ultrasound at the tertiary hospital revealed intussusception. The patient underwent laparoscopic hemicolectomy as air reduction was unsuccessful. The postoperative course was uneventful and the infant made a complete recovery.

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“… 6 However, other investigators have found endorphin levels in patients with intussusception to be not significantly different to those of controls. 22 The effect of toxins absorbed from the lumen of the damaged bowel has also been suggested as the cause but is unproven. 20 Knudson has suggested that lethargy in a patient with vomiting, melaena or an abdominal mass may represent a painless case of intussusception.…”

Section: Discussionmentioning

confidence: 99%