Plasma beta-endorphin concentrations and analgesia-muscle relaxation in the newborn infant supported by mechanical ventilation

Ionides, S. P.; Weiss, M; Angelopoulos, Margarite; Myers, Thomas F.; Handa, Robert J.

doi:10.1016/s0022-3476(94)70136-9

Cited by 23 publications

(5 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Newborn infants undergoing intensive care are subjected to repeated nursing and therapeutic interventions and handling, which are associated with deterioration in physiological parameters such as blood pressure, heart rate, and oxygenation. Although no generally accepted standards are available for the distinction between stressful and painful stimuli, it is obvious from studies on behavioral pain assessment 1,2 and stress hormones [3][4][5][6] that newborn infants in intensive care are distressed. Reluctance to provide adequate analgesia during and after surgical procedures has been associated with increased morbidity and mortality rates.…”

mentioning

confidence: 99%

Morphine clearance and effects in newborn infants in relation to gestational age

Saarenmaa

2000

Clinical Pharmacology & Therapeutics

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Morphine clearance and effects in newborn infants in relation to gestational age

Saarenmaa

2000

Clinical Pharmacology & Therapeutics

View full text Add to dashboard Cite

show abstract

“…The serum alfentanil concentration was 21 (17)(18)(19)(20)(21)(22) ng/ml after administration of 10 ig/kg and 49 (40-50) ng/ml after 20 jg/kg. Two infants had residual alfentanil concentrations of 11 ng/ml and 13 ng/ml when they received placebo as their second dose.…”

Section: Resultsmentioning

confidence: 94%

Alfentanil as procedural pain relief in newborn infants.

Saarenmaa¹,

Huttunen²,

Leppäluoto³

et al. 1996

Archives of Disease in Childhood - Fetal and Neonatal Edition

View full text Add to dashboard Cite

Ains-To assess the need for, and the suitability of, alfentanil for pain relief during tracheal suction used in assisted ventilation in newborn infants. Methods-In a randomised, controlled, double blind, crossover trial, placebo (10 lig/kg) and 20 &Ig/kg alfentanil were infused in random order two minutes before three separate endotracheal suctions, at least six hours apart, to 10 infants. Measurements were made of physiological variables, behaviour, and stress hormones. Results-After placebo infusion heart rate significantly increased (median 14; interquartile range 12-16 beats/minute) as did behavioural pain score (5; 3-5). Alfentanil (20 /gIkg) attenuated the heart rate increase, normalised the pain score, and caused a decrease in plasma adrenaline activity (0.3; 0.2-0.7 nmoMl). Noradrenaline concentration showed a nonsignificant decreasing trend with increasing alfentanil dose and Pi endorphin was unchanged. Rigidity was noted in the placebo (n=2), 10 igIkg (n=2), and 20 igIkg (n=5) alfentanil groups, respectively. Conclusions-Tracheal suction is a painful procedure. The dose of alfentanil required for pain relief (20 sgIkg) causes a high incidence of rigidity and thus should be used only with muscle relaxant. (Arch Dis Child 1996;75:F103-F107)

show abstract

“…Increases in the endogenous opioid beta-endorphin have also been observed in neonates undergoing mechanical ventilation and are reduced by treatment with opioids ( 115 ). In an RCT of neonates undergoing endotracheal suctioning, no changes in beta-endorphin levels were observed, neither in the analgesia group nor in the placebo group, which may have been due to not sampling at the right time point ( 37 ).…”

Section: Monitoring- and Response-biomarkersmentioning

confidence: 99%

Biomarkers for assessing pain and pain relief in the neonatal intensive care unit

ten Barge,

Baudat,

Meesters

et al. 2024

Front. Pain Res.

View full text Add to dashboard Cite

Newborns admitted to the neonatal intensive care unit (NICU) regularly undergo painful procedures and may face various painful conditions such as postoperative pain. Optimal management of pain in these vulnerable preterm and term born neonates is crucial to ensure their comfort and prevent negative consequences of neonatal pain. This entails accurate and timely identification of pain, non-pharmacological pain treatment and if needed administration of analgesic therapy, evaluation of treatment effectiveness, and monitoring of adverse effects. Despite the widely recognized importance of pain management, pain assessment in neonates has thus far proven to be a challenge. As self-report, the gold standard for pain assessment, is not possible in neonates, other methods are needed. Several observational pain scales have been developed, but these often rely on snapshot and largely subjective observations and may fail to capture pain in certain conditions. Incorporation of biomarkers alongside observational pain scores holds promise in enhancing pain assessment and, by extension, optimizing pain treatment and neonatal outcomes. This review explores the possibilities of integrating biomarkers in pain assessment in the NICU.

show abstract

Plasma beta-endorphin concentrations and analgesia-muscle relaxation in the newborn infant supported by mechanical ventilation

Cited by 23 publications

References 14 publications

Morphine clearance and effects in newborn infants in relation to gestational age

Morphine clearance and effects in newborn infants in relation to gestational age

Alfentanil as procedural pain relief in newborn infants.

Biomarkers for assessing pain and pain relief in the neonatal intensive care unit

Contact Info

Product

Resources

About