Plasma B-type natriuretic peptide concentration is independently associated with kidney function decline in Japanese patients with chronic kidney disease

Abstract

Higher BNP levels were associated with adverse renal outcomes, independent of cardiac structure and function, suggesting that BNP may be a useful biomarker for exploring factors associated with kidney disease progression.

N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population ― The Ohasama Study ―

“…According to a previous study (2012 Kidney Disease: Improving Global Outcomes [KDIGO] Clinical Practice Guideline for the Evaluation and Management of CKD), CKD grade (G) was classified as follows: G1A2-3, eGFR ≥90 mL/min/1.73 m 2 and moderately to severely increased proteinuria; G2A2-3, 60≤eGFR<90 mL/ min/1.73 m 2 and moderately to severely increased proteinuria; G3aA1, 45≤eGFR<60 mL/min/1.73 m 2 and normal to mildly increased proteinuria; G3aA2-3, 45≤eGFR<60 mL/ min/1.73 m 2 and moderately to severely increased proteinuria; and G3bA1, 30≤eGFR<45 mL/min/1.73 m 2 and normal addition, several studies have demonstrated an association between progression of CKD and NT-proBNP or BNP. [8][9][10][11] Most of those studies, however, evaluated patients with CKD or renal insufficiency 8-10 and used BNP. 8,9 NT-proBNP is considered a more discerning marker than BNP to evaluate cardiac dysfunction.…”

Association of B-Type Natriuretic Peptide Level with Residual Kidney Function in Incident Peritoneal Dialysis Patients

“…Studies have examined the relationship between plasma BNP level and renal function decline (18–20). Recently, in a prospective CKD patient cohort of 372 participants, we found that a high plasma BNP level was associated with an increased risk for the incidence of ESRD with the need for renal replacement therapy or the doubling of serum creatinine after adjustment for clinical parameters, including cardiac structure and function (18).…”

“…Studies have examined the relationship between plasma BNP level and renal function decline (18–20). Recently, in a prospective CKD patient cohort of 372 participants, we found that a high plasma BNP level was associated with an increased risk for the incidence of ESRD with the need for renal replacement therapy or the doubling of serum creatinine after adjustment for clinical parameters, including cardiac structure and function (18). Yasuda et al reported that, in 485 patients with CKD stage 3, 4, and 5, the plasma BNP level was significantly higher in patients who reached ESRD or the doubling of serum creatinine compared with those who did not (median [interquartile range]: 116 [51.5–318.0] ng/Lvs 53.7 [24.8–126.0] ng/L) (20).…”

“…Plasma BNP is also considered a representative cardiac biomarker for CRS (16,17). We recently reported that renal function decreased earlier in the highest plasma BNP quartile compared with the lowest plasma BNP quartile in CKD patients (hazard ratio [HR]: 4.29, 95% confidence interval [CI]: 2.05 – 9.39) (18). In addition, several studies have reported an association between plasma BNP level and progression of CKD (19,20).…”

N-Terminal Pro–B-Type Natriuretic Peptide and Incident CKD

“…Several hospital-based studies have shown that serum NT-proBNP levels are associated with the progression of kidney impairment in patients with CKD. [15][16][17][18][19][20][21] However, only 3 community-based prospective studies have investigated the association of plasma BNP or serum NT-proBNP levels with the risk of CKD. [22][23][24] Moreover, no studies have addressed the potential use of serum NT-proBNP as a biomarker to improve the prediction of future onset of CKD.…”