Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects

Morán, Javier; Cohen, Lionel; Greene, J.; Xu, Guoqiang; Feldman, Elaine B.; Hames, Curtis G.; Feldman, Daniel S.

doi:10.1093/ajcn/57.2.213

Cited by 108 publications

(47 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Antioxidant vitamins reduced blood pressure and arterial stiffness in patients with diabetes (240), but had no effect in postmenopausal women or in healthy subjects (140). Population studies have demonstrated an inverse association between plasma vitamin C levels and vitamin C consumption with blood pressure (28,139), and a recent meta-analysis reported that vitamin C supplementation reduced systolic and diastolic blood pressure (147). In patients with white coat hypertension, serum protein carbonyl (indicating protein oxidation) was increased and endogenous antioxidant proteins (protein thiol, SOD, glutathione) were decreased compared with normotensive individuals, further supporting a relationship between low antioxidant capacity, increased oxidative stress, and hypertension (201).…”

Section: Ros Oxidative Stress and Human Hypertensionmentioning

confidence: 99%

Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research

Montezano

Touyz²

2014

Antioxidants & Redox Signaling

232

177

View full text Add to dashboard Cite

Significance: Reactive oxygen species (ROS) are signaling molecules that are important in physiological processes, including host defense, aging, and cellular homeostasis. Increased ROS bioavailability and altered redox signaling (oxidative stress) have been implicated in the onset and/or progression of chronic diseases, including hypertension. Recent Advances: Although oxidative stress may not be the only cause of hypertension, it amplifies blood pressure elevation in the presence of other pro-hypertensive factors, such as salt loading, activation of the renin-angiotensin-aldosterone system, and sympathetic hyperactivity, at least in experimental models. A major source for ROS in the cardiovascular-renal system is a family of nicotinamide adenine dinucleotide phosphate oxidases (Noxs), including the prototypic Nox2-based Nox, and Nox family members: Nox1, Nox4, and Nox5. Critical Issues: Although extensive experimental data support a role for increased ROS levels and altered redox signaling in the pathogenesis of hypertension, the role in clinical hypertension is unclear, as a direct causative role of ROS in blood pressure elevation has yet to be demonstrated in humans. Nevertheless, what is becoming increasingly evident is that abnormal ROS regulation and aberrant signaling through redoxsensitive pathways are important in the pathophysiological processes which is associated with vascular injury and target-organ damage in hypertension. Future Directions: There is a paucity of clinical information related to the mechanisms of oxidative stress and blood pressure elevation, and a few assays accurately measure ROS directly in patients. Such further ROS research is needed in humans and in the development of adequately validated analytical methods to accurately assess oxidative stress in the clinic. Antioxid. Redox Signal. 20,[164][165][166][167][168][169][170][171][172][173][174][175][176][177][178][179][180][181][182]

show abstract

Section: Ros Oxidative Stress and Human Hypertensionmentioning

confidence: 99%

Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research

Montezano

Touyz²

2014

Antioxidants & Redox Signaling

232

177

View full text Add to dashboard Cite

show abstract

“…(1980)(1981)(1982)(1983)(1984)(1985)(1986)(1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996) using the search terms 'blood pressure' and 'ascorbic acid'. This was complemented by a Eleven studies 18,22,[25][26][27]30,[32][33][34][35][36] reported on the association between blood levels of vitamin C and search of personal bibliographic files, books and relevant reviews, 7,8,12,13 and follow-up of citations in BP in 14 populations. In 10 of these 14 populations a significant inverse association was reported, but in references already located.…”

Section: Laboratory Studies and Animal Experiments Suggestmentioning

confidence: 99%

“…In 10 of these 14 populations a significant inverse association was reported, but in references already located. We continued the process of cross-referencing until no new references only four 27,[30][31][32][33][34]36 was it possible to estimate directly the difference in BP for a 50 mol/L difference in were identified. These searches were not restricted to English language journals but all the articles plasma ascorbic acid.…”

Section: Laboratory Studies and Animal Experiments Suggestmentioning

confidence: 99%

Vitamin C and blood pressure–an overview

Ness¹,

1997

View full text Add to dashboard Cite

Background: Laboratory and some epidemiological reported an inverse association with vitamin C intake. studies suggest that antioxidants, such as vitamin C,The two non-randomised and four randomised conare protective for cardiovascular disease. This protectrolled trials were all small. Of the randomised trials one tive effect may be mediated through blood pressure reported a significant decrease in BP, one a non-(BP). This is the first systematic review of epidemiologsignificant decrease and two were uninterpretable. ical studies of vitamin C and BP.Conclusions: We found a consistent cross-sectional Method: Published cross-sectional studies, prospective association between higher vitamin C intake or status studies and trials in humans were identified that examand lower BP, though no study controlled adequately ined the association between vitamin C intake or plasma for confounding by other dietary factors. Further crossvitamin C levels and BP. Relevant references were sectional studies are required to establish whether an located by MEDLINE search 1966-1996, EMBASE search independent association exists. If this is shown to be 1980-1996, by searching personal bibliographies, books the case larger and longer term trials will be needed to and reviews and from citations in located articles.confirm the association is causal. Potentially the impact Results: Cross-sectional data were available from 18 on cardiovascular disease of a modest change in mean populations. Ten of 14 reported an inverse association population vitamin C intake is large. between plasma vitamin C and BP and three of four

show abstract

“…33 In addition, it can regenerate vitamin E from the radical form. 45 A number of epidemiological studies have shown a negative correlation between BP and vitamin C. [57][58][59][60] Several mechanisms by which vitamin C might influence BP have been proposed, 60 including a free radicalscavenging property preventing prostacyclin synthetase inhibition. 58 Moreover, it has also been suggested that BP may influence vitamin C metabolism.…”

Section: Discussionmentioning

confidence: 99%

Low-Density Lipoprotein Oxidation and Vitamins E and C in Sustained and White-Coat Hypertension

et al. 1998

View full text Add to dashboard Cite

Abstract-Low-density lipoprotein oxidation and antioxidant vitamins E and C were investigated in white-coat hypertension in comparison with sustained hypertension and normotension. We selected 21 sustained hypertensive subjects, 21 white-coat hypertensive subjects, and 21 normotensive subjects matched for gender, age, and body mass index. White-coat hypertension was defined as clinical hypertension and daytime ambulatory blood pressure Ͻ139/90 (subjects were also reclassified using 134/90 and 135/85 mm Hg as cutoff points for daytime blood pressure). Blood samples were drawn for lipid profile determination, assessment of fluorescent products of lipid peroxidation in native LDL, evaluation of susceptibility to LDL oxidation in vitro (lag phase and propagation rate), and determination of LDL vitamin E and plasma vitamins E and C contents. 3-13 Some studies have shown that white-coat hypertension is a benign condition, 3,5,6,10,12,13 whereas others have not. 4,[7][8][9]11 We have reported recently that subjects with white-coat hypertension do not show target organ damage and present a lipid profile similar to that in normotensive subjects, 14 suggesting that they could be considered at low cardiovascular risk.Several lines of evidence suggest that hypertension is associated with enhanced oxidative stress, 15-23 although it is not yet clear whether this phenomenon occurs before or after the development of hypertension. An important consequence of increased oxidative stress is LDL oxidation. It has been suggested that beyond the known risk markers for cardiovascular disease, oxidation of LDL could play an important role in the development 24 and progression 25 of atherosclerosis. Moreover, it may contribute to the maintenance of hypertension. 26 -29 It has been reported that LDL is more oxidized in vivo and is more susceptible to oxidation in vitro in hypertensive patients than in normotensive subjects. 30 -32 In such a context, vitamins C 33 and E 34 represent the major antioxidants in the water-and lipid-soluble compartments, respectively, and they are devoted to protect against oxidative damage. To the best of our knowledge, no study apparently has evaluated whether sustained and white-coat hypertensives show differences in LDL oxidation and antioxidant vitamins.The present study was designed to investigate LDL oxidation, evaluating fluorescent products of lipid peroxidation in native lipoproteins and susceptibility to oxidation in vitro, and antioxidant vitamins E and C in subjects with white-coat hypertension compared with subjects with normotension and those with sustained hypertension. Methods SubjectsWe selected 21 normotensive, 21 white-coat hypertensive (see below for definition), and 21 sustained hypertensive subjects matched for gender, age, and body mass index. Exclusion criteria for entry in the study were smoking habits, diabetes mellitus, hypercholesterolemia (Ͼ5.7 mmol/L), hypertriglyceridemia (Ͼ2.9 mmol/L), antihypertensive and lipid-lowering drug use (present or past), antioxidant sub-

show abstract

Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects

Cited by 108 publications

References 20 publications

Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research

Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research

Vitamin C and blood pressure–an overview

Low-Density Lipoprotein Oxidation and Vitamins E and C in Sustained and White-Coat Hypertension

Contact Info

Product

Resources

About