Plasma apixaban concentrations and thrombin generation assay parameters in response to dose reduction for atrial fibrillation
Muhan Yeo,
So‐Ryoung Lee,
Eue‐Keun Choi
et al.
Abstract:AimsTo investigate plasma apixaban concentrations and thrombin generation assay (TGA) parameters across different apixaban doses in atrial fibrillation patients who had dose‐reduction criteria for apixaban.MethodsThis observational study included 374 patients (mean age 75.6 ± 7.7 years, 54.8% female) with dose‐reduction criteria for apixaban. The patients were divided into 3 groups: (i) on‐label standard dose (5 mg twice daily, n = 166); (ii) on‐label reduced dose (2.5 mg twice daily, n = 55); and (iii) off‐la… Show more
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