Plasma apelin level after percutaneous coronary intervention

Abdelaziz, Ayman Ahmed; Daoud, Eid M.; Elmalky, Nader; El-Hussiny, Mona Abo Bakr; Mohamed, Sahar Alsayed

doi:10.1016/j.ehj.2014.04.007

“…The results of the study showed a significant decrease (P≤0.05) in the concentration of Apelin for the group of patients as shown in Figure (1) where the concentration was (0.064 ± 0.018) ng / ml compared with control group (0.759 ±0.194) ng / ml, these results were in agreement with [12], while there was no significant difference between males and females for both groups of patients and control. The concentration of Apelin for the group of male patients was (0.059 ± 0.024) ng/ml and females (0.063 ± 0.025) ng/ml.…”

Section: -The Apelin Concentrationsupporting

confidence: 71%

“…The concentration of Apelin for the group of male patients was (1.617 ± 0.672) mg/dL and females (1.813 ± 0.611) mg/dL. The males control group (2.081 ± 0.482) mg/dL and females (1.983 ± 0.277) mg/dL as shown in Figure (12). In this study, serum magnesium was associated with inflammation, arrhythmia, and functional of the endothelial layer [25].…”

Section: -Magnesium Ion Concentration and Its Relation To The Concent...mentioning

confidence: 83%

Apelin Levels and its Relationship with a Number of Electrolytes in Patients with Myocardial Infarction

Humesh¹,

AL-Samarraie²,

AL-Samarraie³

2018

Tikrit J. Pure Sci.

0

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The study aimed to determine the effect of the lack of Apelin peptide and its relation to the development and severity of coronary atherosclerosis and to prove its association with acute myocardial infarction and the positive effect when increasing its concentration in the body and protect it from various diseases. The study included 70 patients of different ages infected with myocardial infarction, both high blood pressure and diabetes, were significantly presented in the group of patients in this study and were compared with control group, which included 35 samples of healthy people. The study showed that there was a significant decrease (P≤0.05) in Apelin concentration in people who suffered from myocardial infarction compared with the control group, which was their Apelin concentrations within the normal rates, there was a significant decrease (P≤ 0.05) in the concentration of Apelin with males and females who suffered from myocardial infarction compared with males and females in control group, which was within normal concentrations that existed in the blood, parameters were measured the concentrations of Apelin and the results of study as follows: There was a significant decrease (P≤0.05) in the concentration of sodium, potassium, chloride and magnesium ions in patients with myocardial infarction compared with the control group. The concentrations of electrolytes in the sera of males and females were significantly decreases (P≤0.05) in regard to sodium, potassium and chloride ions in males and females patients compared to control group, while there were no significant differences (P≤0.05) in the concentration of magnesium between males and females of patients and control group. The correlation of sodium, potassium, magnesium and chloride ions with the concentration of the Apelin was positive. It rises continuously with elevation in the concentration of the Apelin and decrease in the concentration of Apelin. This has a positive effect on myocardial function and improve its function.

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“…The results of the study showed a significant decrease (P≤0.05) in the concentration of Apelin for the group of patients as shown in Figure (1) where the concentration was (0.064 ± 0.018) ng / ml compared with control group (0.759 ±0.194) ng / ml, these results were in agreement with [12], while there was no significant difference between males and females for both groups of patients and control. The concentration of Apelin for the group of male patients was (0.059 ± 0.024) ng/ml and females (0.063 ± 0.025) ng/ml.…”

Section: -The Apelin Concentrationsupporting

confidence: 70%

Apelin Levels and its Relationship with a Number of Electrolytes in Patients with Myocardial Infarction

2018

Tikrit J. Pure Sci.

0

View full text Add to dashboard Cite

The study aimed to determine the effect of the lack of Apelin peptide and its relation to the development and severity of coronary atherosclerosis and to prove its association with acute myocardial infarction and the positive effect when increasing its concentration in the body and protect it from various diseases. The study included 70 patients of different ages infected with myocardial infarction, both high blood pressure and diabetes, were significantly presented in the group of patients in this study and were compared with control group, which included 35 samples of healthy people. The study showed that there was a significant decrease (P≤0.05) in Apelin concentration in people who suffered from myocardial infarction compared with the control group, which was their Apelin concentrations within the normal rates, there was a significant decrease (P≤ 0.05) in the concentration of Apelin with males and females who suffered from myocardial infarction compared with males and females in control group, which was within normal concentrations that existed in the blood, parameters were measured the concentrations of Apelin and the results of study as follows: There was a significant decrease (P≤0.05) in the concentration of sodium, potassium, chloride and magnesium ions in patients with myocardial infarction compared with the control group. The concentrations of electrolytes in the sera of males and females were significantly decreases (P≤0.05) in regard to sodium, potassium and chloride ions in males and females patients compared to control group, while there were no significant differences (P≤0.05) in the concentration of magnesium between males and females of patients and control group. The correlation of sodium, potassium, magnesium and chloride ions with the concentration of the Apelin was positive. It rises continuously with elevation in the concentration of the Apelin and decrease in the concentration of Apelin. This has a positive effect on myocardial function and improve its function.

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“…Of these, 2670 were excluded as duplicates and 1391 remained as the screened records. Finally, 24 articles (30 studies) were included as the final records of the current meta-analysis [ 6 , 15 , 16 , 18 – 38 ]. The included studies had been published between 2006 and 2020 and were comprised of 1793 cases and 1416 controls.…”

Section: Resultsmentioning

confidence: 99%

Apelin and its ratio to lipid factors are associated with cardiovascular diseases: A systematic review and meta-analysis

Akbari

¹

,

Hosseini-Bensenjan

²

,

Salahi

³

et al. 2022

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Background The present systematic review and meta-analysis aimed to ascertain if the circulating levels of apelin, as an important regulator of the cardiovascular homeostasis, differ in patients with cardiovascular diseases (CVDs) and controls. Methods A comprehensive search was performed in electronic databases including PubMed, Scopus, EMBASE, and Web of Science to identify the studies addressing apelin in CVD up to April 5, 2021. Due to the presence of different units to measure the circulating levels of apelin across the included studies, they expressed the standardized mean difference (SMD) and their 95% confidence interval (CI) as summary effect size. A random-effects model comprising DerSimonian and Laird method was used to pool SMDs. Results Twenty-four articles (30 studies) comprised of 1793 cases and 1416 controls were included. Pooled results obtained through random-effects model indicated that apelin concentrations in the cases’ blood samples were significantly lower than those of the control groups (SMD = -0.72, 95% CI: -1.25, -0.18, P = 0.009; I2 = 97.3%, P<0.001). New combined biomarkers showed a significant decrease in SMD of apelin/high-density lipoprotein cholesterol (apelin/HDL-C) ratio [-5.17; 95% CI, -8.72, -1.63, P = 0.000; I2 = 99.0%], apelin/low-density lipoprotein cholesterol (apelin/LDL-C) ratio [-4.31; 95% CI, -6.08, -2.55, P = 0.000; I2 = 98.0%] and apelin/total cholesterol (apelin/TC) ratio [-17.30; 95% CI, -22.85, -11.76, P = 0.000; I2 = 99.1%]. However, no significant differences were found in the SMD of apelin/triacylglycerol (apelin/TG) ratio in cases with CVDs compared to the control group [-2.96; 95% CI, -7.41, 1.49, P = 0.000; I2 = 99.2%]. Conclusion The association of apelin with CVDs is different based on the region and disease subtypes. These findings account for the possible usefulness of apelin as an additional biomarker in the diagnosis of CVD in diabetic patients and in the diagnosis of patients with CAD. Moreover, apelin/HDL-c, apelin/LDL-c, and apelin/TC ratios could be offered as diagnostic markers for CVD.

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Plasma apelin level after percutaneous coronary intervention

Cited by 3 publications

References 27 publications

Apelin Levels and its Relationship with a Number of Electrolytes in Patients with Myocardial Infarction

Apelin Levels and its Relationship with a Number of Electrolytes in Patients with Myocardial Infarction

Apelin Levels and its Relationship with a Number of Electrolytes in Patients with Myocardial Infarction

Apelin and its ratio to lipid factors are associated with cardiovascular diseases: A systematic review and meta-analysis

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