Plasma Antioxidants and Lipid Peroxidation Products in Falciparum Malaria

Das, B. S.; Patnaik, J.K.; Mohanty, S. R.; Mishra, Sanatan; Mohanty, Dipika; Satpathy, Sudhir; Bose, Tarit K.

doi:10.4269/ajtmh.1993.49.720

Cited by 66 publications

(39 citation statements)

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“…This was in consistency with other reported work where such similar rise in MDA in falciparum malaria has been attributed to be a measure of severity of tissue damage (6,(10)(11)(12). The assumption that serum MDA reflects the oxidative damage of tissues particularly in erythrocytes, which are in direct and continuous contact with plasma and in which the peroxide is generated as a result of oxidative stress perhaps, holds good for ARF patients in our study.…”

Section: Discussionsupporting

confidence: 81%

Evaluating role of oxidative stress in determining the pathogenesis of falciparum malaria induced acute renal failure

Nanda

Mishra

Das

et al. 2004

Indian J Clin Biochem

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Serum malondialdehyde was measured in sixty-one falciparum malaria cases, which include thirty uncomplicated, and thirty-one complicated with acute renal failure. Twenty-six healthy individuals were also studied as controls. Serum malondialdehyde level was found to be significantly elevated in falciparum malaria induced acute renal failure cases when compared with uncomplicated falciparum malaria (p<0.001) and healthy controls (p<0.001). A positive correlation with the raised urea, creatinine and bilirubin levels were significant (r=0. 62, p<0.025; r=0.65, p<0.05 and r=0.72, p<0.001 respectively) indicating the severity of complication with rise of lipid peroxides in falciparum malaria induced acute renal failure cases.

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Section: Discussionsupporting

confidence: 81%

Evaluating role of oxidative stress in determining the pathogenesis of falciparum malaria induced acute renal failure

Nanda

Mishra

Das

et al. 2004

Indian J Clin Biochem

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“…Vitamin E is the major chain terminating antioxidant in membranes; it reduces both conjugated dienyl and hydroperoxyl radicals, quenching the chain or cycle or lipid peroxidation reactions. Studies have demonstrated that lipid peroxide levels can reflect the severity of a disease process (Das, et al 1993) and increased MDA is an indicator of reactive oxygen species (ROS) generation in the tissue (Halliwell and Hutteridge, 1989).…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Hepatoprotective Effects of Dried Flower Extracts of Hibiscus sabdariffa L. on Rats Treated with Carbon Tetrachloride

Usoh¹

2012

J. App. Pharm. Sci.

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The hypolipidemic, antioxidative and hepatoprotective activities of 200 and 300mg/kg body weight ethanolic extract of dried flower of Hibiscus sabdariffa L. (HSE) were assessed in rats treated with 0.25ml/kg body weight (intraperitoneally) of carbon tetrachloride (CCl 4 ). Hepatic malondialdehyde (MDA), serum lipid profile, serum vitamins A, C and β-carotene, alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) activities were measured. The oral administration of the extracts showed a significant (P<0.05) dose-dependent decrease in the CCl 4 -induced MDA formation in liver. Also HSE pretreatment, showed a significant increase in HDL-C concentration and decrease in the levels of total cholesterol, LDL-C and TG as compared to control. The levels of vitamins A, C, and β-carotene were shown to be significantly (P<0.05) decreased and increased respectively in CCl 4 and HSE treated groups when compared with the control. The increase in the levels of these vitamins might not be unconnected with the antioxidant properties possessed by the extract. The extract also displayed a strong hepatoprotective effect as it significantly reduced CCl 4-induced hepatotoxicity in rats, as judged from the serum activities of ALT, AST, and ALP. These results suggest that the ethanolic extract of dried flower of Hibiscus sabdariffa L. possesses antioxidant, hepatoprotective and hypolipidemic effects on CCl 4 -induced oxidative stress in rats.

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“…Excess hydrogen peroxide could also results in break down of heme and release of free iron ions, which in turn form OH via Fenton reaction (20). Increased adenosine deaminase activity brings about increased xanthine oxidase activity thereby representing another source of superoxide anion formation (2).…”

Section: Ii) Enhancement Of Oxidant Status In Malaria Patientsmentioning

confidence: 99%

“…Besides this, the plasma of malaria patients has been suspected Indian Journal of Clinical Biochemistry, 2003 136-149 to contain prooxidants. Hemoglobin can act as prooxidant by catalyzing the decomposition of lipid hydropemxides enhancing the chain reaction (20).…”

Section: Ii) Enhancement Of Oxidant Status In Malaria Patientsmentioning

confidence: 99%

Studies on biochemical changes with special reference to oxidant and antioxidants in malaria patients

Kulkarni

Suryakar

Sardeshmukh

et al. 2003

Indian J Clin Biochem

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Oxidative stress plays an important role in the development of maladal anemia. The present study was undertaken to study the role of oxidant and antioxidants in the patients of Plasmodium falciparum malada (n = 25), Plasmodium vivax malada (n = 25) as against the normal control subjects (n =25). The parameters included are the hematological [hemoglobin, erythrocyte adenosine deaminase (ADA) activity, ADP -induced platelet aggregation] and serum total lipid peroxide as an index of oxidative stress and antioxidants [erythrocytic superoxide dismutase (SOD) activity, serum vitamin E] & serum iron.Significant alterations in all above parameters were noted in both groups of malaria patients as compared to control subjects. Maximum significant alterations in hematological parameters were noticed in P. falciparum infection as compared to P. vivax malada (p<0.001). Substantial dse in serum total lipid peroxides and a significant reduction in antioxidants such as serum vitamin E and serum iron were noted in R falciparum malaria as compared to R vivax malada (p< 0.001), whereas maximum decline in erythrocytic SOD activity was observed in R vivax infection as compared to R falciparum malaria (p<0.05). Follow-up examination revealed the restoration of the levels of all biochemical parameters to the normal level after 20 days of antimalarial therapy.The study specified severity of P. falciparum malaria and also functional duality of oxidant.

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Plasma Antioxidants and Lipid Peroxidation Products in Falciparum Malaria

Cited by 66 publications

References 0 publications

Evaluating role of oxidative stress in determining the pathogenesis of falciparum malaria induced acute renal failure

Evaluating role of oxidative stress in determining the pathogenesis of falciparum malaria induced acute renal failure

Antioxidant and Hepatoprotective Effects of Dried Flower Extracts of Hibiscus sabdariffa L. on Rats Treated with Carbon Tetrachloride

Studies on biochemical changes with special reference to oxidant and antioxidants in malaria patients

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